2. Gene
  3. Apoe - apolipoprotein E Gene

Apoe - apolipoprotein E Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：载脂蛋白E

种属: Mus musculus

同用名: Apo-E

基因 ID: 11816 | 基因类型: protein coding

关于 Apoe

Chromosome 7: 19,430,034-19,433,113 reverse strand.GRCm39:CM001000.3

This gene has 11 transcripts (splice variants), 222 orthologues, 3 paralogues and is associated with 190 phenotypes. Biased expression in liver adult (RPKM 95.), liver E18 (RPKM 4149.1) and 1 other tissues.

功能概要

该基因编码载脂蛋白 A1/A4/E 蛋白家族的成员。这种蛋白质参与血液中脂蛋白的运输。它与特定的肝脏和外周细胞受体结合，对于富含甘油三酯的脂蛋白成分的正常分解代谢至关重要。该基因的纯合基因敲除小鼠在血液中积累高水平的胆固醇并发展为动脉粥样硬化。该基因的不同等位基因与人类患者患阿尔茨海默病的风险增加或保护作用有关。该基因与相关的载脂蛋白 C1、C2 和 C4 基因一起映射到 7 号染色体。 [RefSeq 提供，2015 年 4 月]

This gene encodes a member of the Apolipoprotein A1/A4/E family of proteins. This protein is involved in the transport of lipoproteins in the blood. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. Homozygous knockout mice for this gene accumulate high levels of Cholesterol in the blood and develop atherosclerosis. Different alleles of this gene have been associated with either increased risk or a protective effect for Alzheimer's disease in human patients. This gene maps to chromosome 7 in a cluster with the related Apolipoprotein C1, C2 and C4 genes. [provided by RefSeq, Apr 2015]

Apoe 基因产物(4)

mRNA Protein Name
NM_001305844.1 NP_001292773.1 apolipoprotein E precursor
NM_001305843.1 NP_001292772.1 apolipoprotein E precursor
NM_001305819.1 NP_001292748.1 apolipoprotein E precursor
NM_009696.4 NP_033826.2 apolipoprotein E precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cholesterol transfer activity IDA
IDA: 通过直接分析推断
15269218 MGI
enables heparan sulfate proteoglycan binding IDA
IDA: 通过直接分析推断
23676495 MGI
enables lipoprotein particle binding IDA
IDA: 通过直接分析推断
11553788 MGI
enables phosphatidylcholine-sterol O-acyltransferase activator activity IMP
IMP: 通过突变表型推断
15654758 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
23055941 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within artery morphogenesis IGI
IGI: 通过遗传相互作用推断
16230502 MGI
NOT acts upstream of or within axon regeneration IGI
IGI: 通过遗传相互作用推断
7798939 MGI
acts upstream of or within cholesterol catabolic process IMP
IMP: 通过突变表型推断
9826706 MGI
acts upstream of or within cholesterol efflux IDA
IDA: 通过直接分析推断
15269218 MGI
acts upstream of or within cholesterol efflux IMP
IMP: 通过突变表型推断
11551841 MGI
acts upstream of or within cholesterol homeostasis IGI
IGI: 通过遗传相互作用推断
11120757 MGI
acts upstream of or within cholesterol homeostasis IMP
IMP: 通过突变表型推断
1423598 MGI
involved in cholesterol homeostasis IMP
IMP: 通过突变表型推断
23741427 MGI
acts upstream of or within cholesterol metabolic process IMP
IMP: 通过突变表型推断
1423598 MGI
acts upstream of or within circulatory system development IMP
IMP: 通过突变表型推断
19816508 MGI
acts upstream of or within negative effect gene expression IGI
IGI: 通过遗传相互作用推断
26397958 MGI
acts upstream of or within intracellular calcium ion homeostasis IDA
IDA: 通过直接分析推断
8185566 MGI
acts upstream of or within lipid homeostasis IMP
IMP: 通过突变表型推断
17720994 MGI
acts upstream of or within lipid metabolic process IGI
IGI: 通过遗传相互作用推断
11120757 MGI
involved in lipid transport involved in lipid storage IMP
IMP: 通过突变表型推断
23741427 MGI
acts upstream of or within lipoprotein biosynthetic process IGI
IGI: 通过遗传相互作用推断
14595002 MGI
acts upstream of or within lipoprotein catabolic process IMP
IMP: 通过突变表型推断
17720994 MGI
acts upstream of or within lipoprotein metabolic process IGI
IGI: 通过遗传相互作用推断
11120757 MGI
acts upstream of or within lipoprotein metabolic process IMP
IMP: 通过突变表型推断
9788969 MGI
involved in low-density lipoprotein particle remodeling IMP
IMP: 通过突变表型推断
15654758 MGI
acts upstream of or within maintenance of location in cell IMP
IMP: 通过突变表型推断
17720994 MGI
involved in melanosome organization IMP
IMP: 通过突变表型推断
26387950 MGI
involved in negative regulation of amyloid fibril formation IMP
IMP: 通过突变表型推断
14741101 MGI
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
18377911 MGI
involved in negative regulation of inflammatory response IGI
IGI: 通过遗传相互作用推断
21784977 MGI
acts upstream of negative regulation of smooth muscle cell proliferation IGI
IGI: 通过遗传相互作用推断
18382765 MGI
acts upstream of or within negative regulation of triglyceride metabolic process IGI
IGI: 通过遗传相互作用推断
9240444 MGI
involved in positive regulation of CoA-transferase activity IMP
IMP: 通过突变表型推断
15654758 MGI
involved in positive regulation of amyloid-beta clearance IMP
IMP: 通过突变表型推断
14741101 MGI
involved in positive regulation of cholesterol efflux IMP
IMP: 通过突变表型推断
31902528 MGI
involved in positive regulation of cholesterol metabolic process IMP
IMP: 通过突变表型推断
15654758 MGI
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
23845000 MGI
NOT acts upstream of or within protein localization IMP
IMP: 通过突变表型推断
9325076 MGI
involved in regulation of apoptotic process IMP
IMP: 通过突变表型推断
29336888 MGI
acts upstream of or within regulation of gene expression IMP
IMP: 通过突变表型推断
17720994 MGI
involved in regulation of innate immune response IMP
IMP: 通过突变表型推断
29336888 MGI
involved in regulation of plasma lipoprotein particle levels IMP
IMP: 通过突变表型推断
23741427 MGI
involved in regulation of synapse organization IDA
IDA: 通过直接分析推断
27683909 MGI
involved in regulation of synapse organization IMP
IMP: 通过突变表型推断
27683909 MGI
acts upstream of or within response to dietary excess IMP
IMP: 通过突变表型推断
17720994 MGI
acts upstream of or within response to oxidative stress IMP
IMP: 通过突变表型推断
8773783 MGI
involved in triglyceride homeostasis IMP
IMP: 通过突变表型推断
23676495 MGI
involved in triglyceride-rich lipoprotein particle clearance IMP
IMP: 通过突变表型推断
23676495 MGI
acts upstream of or within vasodilation IMP
IMP: 通过突变表型推断
9826706 MGI
involved in very-low-density lipoprotein particle remodeling IMP
IMP: 通过突变表型推断
15654758 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
7798939 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
27683909 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
27683909 MGI
part of low-density lipoprotein particle IDA
IDA: 通过直接分析推断
15654758 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Apoe 蛋白结构

Apolipoprotein

Apolipoprotein: pfam01442 (77 - 257)

  • 0
  • 100
  • 200
  • 311 a.a.
蛋白主名 其他名称

apolipoprotein E

重组 Apoe 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7532 Apolipoprotein E/APOE Protein, Mouse (HEK293, His) P08226 (E19-Q311) ≥95%
HY-P78239 Apolipoprotein E/APOE Protein, Mouse (HEK293, Fc) P08226 (E19-Q311) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-103076 EZ-482 97.11% 否
HY-112798 PH-002 Inhibitor 98.78% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Apoe NCBI NCBI:348
Leporidae Apoe NCBI
Rattus norvegicus Apoe NCBI NCBI:25728
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