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  3. Areg - amphiregulin Gene

Areg - amphiregulin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: AR; Mcub; Sdgf

基因 ID: 11839 | 基因类型: protein coding

关于 Areg

功能概要

This gene encodes a member of the epidermal growth factor (EGF) family and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and has been shown to play a role in immunity, inflammation, tissue repair, and lung and mammary gland development. Homozygous knockout mice for this gene exhibit impaired immune system regulation in the skin and gene expression changes characteristic of chronic liver damage. [provided by RefSeq, Aug 2015]

Areg 基因产物(1)

mRNA Protein Name
NM_009704.4 NP_033834.1 amphiregulin preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables receptor ligand activity IGI
IGI: 通过遗传相互作用推断
23086930 MGI
enables transmembrane receptor protein tyrosine kinase activator activity IGI
IGI: 通过遗传相互作用推断
23086930 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis IMP
IMP: 通过突变表型推断
17369357 MGI
involved in epidermal growth factor receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
23086930 MGI
acts upstream of or within epithelial cell proliferation involved in mammary gland duct elongation IMP
IMP: 通过突变表型推断
17369357 MGI
acts upstream of or within mammary gland alveolus development IGI
IGI: 通过遗传相互作用推断
10331984 MGI
acts upstream of or within mammary gland branching involved in thelarche IMP
IMP: 通过突变表型推断
10331984 MGI
acts upstream of or within positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
8702723 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
8702723 MGI
acts upstream of or within response to estradiol IDA
IDA: 通过直接分析推断
17369357 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
8588926 MGI
is active in extracellular space IDA
IDA: 通过直接分析推断
23086930 MGI
is active in extracellular space IGI
IGI: 通过遗传相互作用推断
30770250 MGI
located in intracellular anatomical structure IDA
IDA: 通过直接分析推断
8588926 MGI
located in nucleus IDA
IDA: 通过直接分析推断
8588926 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

amphiregulin

schwannoma-derived growth factor

重组 Areg 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77868 Amphiregulin Protein, Mouse (HEK293, Fc) P31955 (V100-A248) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00892 AREG Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Areg NCBI NCBI:374
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