Casp8 - caspase 8 Gene

中文名称：半胱天冬酶 8

种属: Mus musculus

同用名: MACH; Mch5; FLICE; CASP-8

关于 Casp8

功能概要

该基因是半胱天冬酶家族的一部分，天冬氨酸特异性半胱氨酸蛋白酶因其参与免疫和细胞凋亡信号而得到充分研究。这种蛋白质是凋亡性细胞死亡的引发剂，被诱导死亡的肿瘤坏死家族受体激活并靶向下游效应子。在小鼠中，该基因的缺陷会导致胚胎死亡。这种蛋白质可能在胚胎发生中起作用。可变剪接导致编码不同蛋白质亚型的多个转录变体。 [RefSeq 提供，2013 年 4 月]

This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and Apoptosis signaling. This protein, an initiator of apoptotic cell death, is activated by death-inducing tumor necrosis family receptors and targets downstream effectors. In mouse deficiency of this gene can cause embryonic lethality. This protein may have a role in embryogenesis. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]