ADH1C - alcohol dehydrogenase 1C (class I), gamma polypeptide Gene

中文名称：乙醇脱氢酶 1C (I 类) ，γ 多肽

种属: Homo sapiens

同用名: ADH3

基因 ID: 126 | 基因类型: protein coding

关于 ADH1C

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:99,336,497-99,352,746 (from NCBI)

This gene has 4 transcripts (splice variants), 363 orthologues, 17 paralogues and is associated with 2 phenotypes. Biased expression in liver (RPKM 388.0), duodenum (RPKM 230.6) and 5 other tissues.

功能概要

该基因编码 I 类醇脱氢酶，γ 亚基，是醇脱氢酶家族的成员。该酶家族的成员代谢多种底物，包括乙醇、视黄醇、其他脂肪醇、羟基类固醇和脂质过氧化产物。 I 类醇脱氢酶由 alpha、beta 和 gamma 亚基的几个同二聚体和异二聚体组成，对乙醇氧化成乙醛表现出高活性，因此在乙醇分解代谢中起主要作用。编码 alpha、beta 和 gamma 亚基的三个基因在基因组片段中串联组织为基因簇。尚未确定 ADH1C 多态性和酒精依赖之间的关联。[RefSeq 提供，2019 年 9 月]

This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this Enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation to acetaldehyde, thus playing a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. An association between ADH1C polymorphism and alcohol dependence has not been established. [provided by RefSeq, Sep 2019]

ADH1C 基因产物(1)

mRNA	Protein	Name
NM_000669.5	NP_000660.1	alcohol dehydrogenase 1C

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables alcohol dehydrogenase (NAD+) activity	IDA IDA: 通过直接分析推断	6391957	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	28514442	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

alcohol dehydrogenase 1C

ADH, gamma subunit

关联疾病

疾病名称

别名

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Parkinson Disease, Late-Onset

Parkinson Disease	Parkinson'S Disease
PD	PARK
Parkinson Disease, Susceptibility To	Late Onset Parkinson'S Disease
Late Onset Parkinson Disease	Paralysis Agitans
Primary Parkinsonism	Idiopathic Parkinson Disease
Parkinson'S	Parkinson Disease, Late-Onset, Susceptibility To
Parkinson Disease, Age Of Onset, Modifier	Lewy Body Parkinson Disease
Idiopathic Parkinson'S Disease	Pd - [Parkinson Disease]
Parkinson Disease Nos	Parkinson, Nos
Primary Parkinson Disease

Parkinson Disease, Mitochondrial

Alcoholic Liver Cirrhosis

Alcoholic Cirrhosis	Portal Cirrhosis
Alcoholic Cirrhosis Of Liver	Liver Cirrhosis, Alcoholic
Laennec'S Cirrhosis	Laennec'S Cirrhosis, Alcoholic
Alcohol Cirrhosis	Alcoholic Laennec Cirrhosis
Alcoholic Cirrhosis Nos	Etoh Cirrhosis
Alcohol Hepatic Cirrhosis	Alcohol Liver Cirrhosis
Laennec Cirrhosis

Oropharynx Cancer

Oropharyngeal Cancer	Oropharyngeal Carcinoma
Malignant Neoplasm Of Oropharynx	Malignant Oropharyngeal Tumor
Malignant Tumor Of Oropharynx	Malignant Tumour Of Mesopharynx
Oropharyngeal Cancer, Adult	Cancer Of The Oropharynx

Pharynx Cancer

Pharyngeal Cancer	Pharyngeal Neoplasms
Pharyngeal Neoplasm	Pharynx Neoplasm
Malignant Neoplasm Of Pharynx	Pharyngeal Carcinoma

Alcoholic Pancreatitis

Pancreatitis, Alcoholic

Pancreatitis Alcoholic

Alcohol Use Disorder

Alcohol Abuse	Alcoholism
Ethanol Abuse	Alcohol Addiction
Alcohol Dependence	Alcoholic Intoxication, Chronic
Alcohol-Related Disorders

Liver Cirrhosis

Cirrhosis	Cirrhosis Of Liver
CIRRH	Cryptogenic Cirrhosis
Cirrhosis, Cryptogenic	Cirrhosis Nos

Pancreatitis

Mumps Pancreatitis

Aspartylglucosaminuria

Aspartylglycosaminuria	Glycosylasparaginase Deficiency
Aspartylglucosaminidase Deficiency	Aga Deficiency
AGU	Aspartylglucosamidase Deficiency
Glycoasparaginase	Aspartylglucosamidase Deficiency
Hyperammonemia, Type Iii

Alcohol-Related Birth Defects

Arbd	Alcohol-Related Birth Defect
Alcohol Related Birth Defect	Fetal Alcohol Syndrome

Substance Dependence

Lip And Oral Cavity Cancer

Oral Cancer	Lip And Oral Cavity Carcinoma
Malignant Neoplasm Of Mouth

Fetal Alcohol Syndrome

Fetal Alcohol Spectrum Disorders	Arbd
Arnd	Alcohol-Related Birth Defects
Alcohol-Related Neurodevelopmental Disorder	Fas
Fasd	Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta Or Breast Milk
Alcohol Related Birth Defect	Alcohol Related Neurodevelopmental Disorder
Alcohol Affecting Fetus Or Newborn Via Placenta Or Breast Milk	Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta And/Or Breast Milk
Dysmorphism Due To Alcohol	Fetal Etoh Syndrome

Substance Abuse

Substance-Related Disorders

Substance Abuse Problem

Fetal Alcohol Spectrum Disorder

Fetal Alcohol Spectrum Disorders

Fetal Alcohol Syndrome

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Squamous Cell Carcinoma, Head And Neck

Squamous Cell Carcinoma Of The Head And Neck	HNSCC
Head And Neck Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Lip
Squamous Cell Carcinoma, Head And Neck, Somatic	Carcinoma Of The Head And Neck
Squamous Cell Carcinomas Of Head And Neck	Scchn
Squamous Cell Carcinoma Of The Hypopharynx	Squamous Cell Carcinoma Of The Oropharynx
Squamous Cell Carcinoma Of Salivary Glands	Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses
Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses	Squamous Cell Carcinoma Of The Oral Cavity
Squamous Cell Carcinoma Of The Lip	Carcinoma, Squamous Cell Of Head And Neck
Lip Squamous Cell Carcinoma	Carcinoma, Squamous Cell, Head And Neck
Salivary Gland Squamous Cell Carcinoma	Cancer Of Head And Neck
Squamous Cell Carcinoma Of Oropharynx Nos

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00368	ADH1C Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	ADH1C	RGD	RGD:2044
Mus musculus	ADH1C	MGD	MGI:87921

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

ADH1C - alcohol dehydrogenase 1C (class I), gamma polypeptide Gene

关于 ADH1C

功能概要

ADH1C 基因产物(1)

关联疾病

直系同源

热门区域

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ADH1C - alcohol dehydrogenase 1C (class I), gamma polypeptide Gene

关于 ADH1C

功能概要

ADH1C 基因产物(1)

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z