2. Gene
  3. LSM11 - LSM11, U7 small nuclear RNA associated Gene

LSM11 - LSM11, U7 small nuclear RNA associated Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：LSM11、U7 小核 RNA 相关

种属: Homo sapiens

同用名: AGS8

基因 ID: 134353 | 基因类型: protein coding

关于 LSM11

Cytogenetic location: 5q33.3 Genomic coordinates (GRCh38): 5:157,743,712-157,760,709 (from NCBI)

This gene has 1 transcript (splice variant), 193 orthologues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 3.6), testis (RPKM 3.3) and 25 other tissues.

功能概要

启用 U7 snRNA 结合活动。参与有丝分裂细胞周期 G1/S 转换的正向调节。位于核体。 U7 snRNP 和端粒酶全酶复合物的一部分。与 Aicardi-Goutieres 综合征有关。 [由基因组资源联盟提供，2022 年 4 月]

Enables U7 snRNA binding activity. Involved in positive regulation of G1/S transition of mitotic cell cycle. Located in nuclear body. Part of U7 snRNP and Telomerase holoenzyme complex. Implicated in Aicardi-Goutieres syndrome. [provided by Alliance of Genome Resources, Apr 2022]

LSM11 基因产物(1)

mRNA Protein Name
NM_173491.4 NP_775762.1 U7 snRNA-associated Sm-like protein LSm11
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables U7 snRNA binding IDA
IDA: 通过直接分析推断
12975319 GOA
enables U7 snRNA binding IPI
IPI: 通过物理相互作用推断
18082603 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12975319 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in mRNA 3'-end processing by stem-loop binding and cleavage IMP
IMP: 通过突变表型推断
33230297 GOA
involved in positive regulation of G1/S transition of mitotic cell cycle IMP
IMP: 通过突变表型推断
16914750 GOA
involved in regulation of chromatin organization IMP
IMP: 通过突变表型推断
33230297 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of U7 snRNP IDA
IDA: 通过直接分析推断
11574479 GOA
located in nucleus IDA
IDA: 通过直接分析推断
12975319 GOA
part of telomerase holoenzyme complex IDA
IDA: 通过直接分析推断
18082603 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LSM11 蛋白结构

LSM

LSM: LSM domain (168 - 208)

  • 0
  • 100
  • 200
  • 300
  • 360 a.a.
蛋白主名 其他名称

U7 snRNA-associated Sm-like protein LSm11

LSM11 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LSM11 P83369 RAB19 Homo sapiens A4D1S5
Y2H Array
32296183
种属内
LSM11 P83369 RAB19 Homo sapiens A4D1S5
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Aicardi-Goutieres Syndrome 8

AGS8
Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1
Cerebrooculofacioskeletal Syndrome 2

COFS2

Cerebro-Oculo-Facio-Skeletal Syndrome 2

Cofs Syndrome
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07854 LSM11 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus LSM11 VGNC VGNC:102246
Mus musculus LSM11 MGD MGI:1919540
Bos taurus LSM11 VGNC VGNC:54446
Rattus norvegicus LSM11 RGD RGD:1565523
Macaca mulatta LSM11 VGNC VGNC:110453
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