S1pr1 - sphingosine-1-phosphate receptor 1 Gene

中文名称：1-磷酸鞘氨醇受体 1

种属: Mus musculus

同用名: S1p; Edg1; Lpb1; S1p1

关于 S1pr1

功能概要

该基因编码由溶血磷脂、1-磷酸鞘氨醇结合的 G 蛋白偶联受体。该基因产物在内皮细胞中发挥作用，并参与血管和心脏发育。该受体在 T 和 B 淋巴细胞中高表达，并在 T 细胞和 B 细胞从外周淋巴器官输出中发挥作用。这种蛋白质被 FTY720 结合并下调，FTY720 是一种外源性免疫抑制药物，在人类多发性硬化症小鼠疾病模型中进行了研究。 [RefSeq 提供，2010 年 1 月]

This gene encodes a G-protein-coupled receptor bound by the lysophospholipid, sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. This receptor is highly expressed in T and B lymphocytes, and it plays a role in T cell and B cell export from peripheral lymphoid organs. This protein is bound and downregulated by FTY720, an exogenous immunosuppressant drug studied in mouse disease models for multiple sclerosis in humans. [provided by RefSeq, Jan 2010]