2. Gene
  3. S1PR1 - sphingosine-1-phosphate receptor 1 Gene

S1PR1 - sphingosine-1-phosphate receptor 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：1-磷酸鞘氨醇受体 1

种属: Homo sapiens

同用名: EDG1; S1P1; CD363; ECGF1; EDG-1; CHEDG1; D1S3362

基因 ID: 1901 | 基因类型: protein coding

关于 S1PR1

Cytogenetic location: 1p21.2 Genomic coordinates (GRCh38): 1:101,236,899-101,242,313 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues and 18 paralogues. Broad expression in fat (RPKM 52.5), lung (RPKM 39.5) and 21 other tissues.

功能概要

该基因编码的蛋白质在结构上与 G 蛋白偶联受体相似，在内皮细胞中高表达。它以高亲和力和高特异性结合配体 1-磷酸鞘氨醇，并表明参与调节内皮细胞分化的过程。该受体的激活诱导细胞间粘附。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 3 月]

The protein encoded by this gene is structurally similar to G protein-coupled receptors and is highly expressed in endothelial cells. It binds the ligand sphingosine-1-phosphate with high affinity and high specificity, and suggested to be involved in the processes that regulate the differentiation of endothelial cells. Activation of this receptor induces cell-cell adhesion. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

S1PR1 基因产物(9)

mRNA Protein Name
NR_174347.1
XR_007095678.1
NR_174349.1
NR_174346.1
NR_174348.1
NM_001320730.2 NP_001307659.1 sphingosine 1-phosphate receptor 1
NR_174350.1
NR_174345.1
NM_001400.5 NP_001391.2 sphingosine 1-phosphate receptor 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled receptor binding IPI
IPI: 通过物理相互作用推断
24851274 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16525420 GOA
enables sphingosine-1-phosphate receptor activity IDA
IDA: 通过直接分析推断
22344443 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T cell migration IDA
IDA: 通过直接分析推断
37039481 GOA
involved in sphingosine-1-phosphate receptor signaling pathway IDA
IDA: 通过直接分析推断
22344443 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
22344443 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

S1PR1 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (62 - 311)

  • 0
  • 100
  • 200
  • 300
  • 382 a.a.
蛋白主名 其他名称

sphingosine 1-phosphate receptor 1

S1P receptor 1

S1P receptor Edg-1

endothelial differentiation G-protein coupled receptor 1

endothelial differentiation, sphingolipid G-protein-coupled receptor, 1

sphingosine 1-phosphate receptor EDG1

sphingosine 1-phosphate receptor Edg-1

关联疾病

疾病名称 别名
Relapsing-Remitting Multiple Sclerosis

Relapsing-Remitting Ms

Relapsing Remitting Multiple Sclerosis

Multiple Sclerosis, Relapsing-Remitting

Rrms

Multiple Sclerosis Relapsing-Remitting
Demyelinating Disease

Demyelinating Diseases

Demyelinating Disorder
Autoimmune Disease Of Central Nervous System
Herpes Zoster Oticus

Nervus Intermedius Neuralgia

Geniculate Herpes Zoster

Geniculate Neuralgia

Ramsay Hunt Syndrome Type 2

Herpes Zoster Auricularis

Herpetic Geniculate Ganglionitis

Ramsay Hunt Syndrome Type Ii

Ramsey Hunt Syndrome

Facial Nerve Palsy Due To Vzv

Facial Nerve Palsy Due To Herpes Zoster Infection

Facial Nerve Paralysis Due To Vzv

Hunt Syndrome

Hunt'S Syndrome

Ramsay Hunt Syndrome

Myoclonus And Ataxia
Dermatitis, Atopic, 7

ATOD7

Dermatitis, Atopic, Susceptibility To, 7

Atopic Dermatitis 7

Dermatitis, Atopic 7
Second-Degree Atrioventricular Block

Second-Degree Heart Block

Second Degree Atrioventricular Block

Second Degree Atrioventricular Heart Block

Second Degree Heart Block

Incomplete Atrioventricular Block, Second Degree Nos

Second-Degree Block, Type 1 And 2

Atrioventricular Block, Type 1 And 2

Second Degree Incomplete Atrioventricular Block

Av - [Atrioventricular] Block 2nd
Multiple Sclerosis

MS

Multiple Sclerosis, Susceptibility To

Disseminated Sclerosis

Multiple Sclerosis, Disease Progression, Modifier Of

Insular Sclerosis

Multiple Sclerosis Modifier Of Disease Progression

Multiple Sclerosis, Susceptibility To 1

Multiple Sclerosis, Susceptibility To, 1

Multiple Sclerosis 1

Generalized Multiple Sclerosis

Multiple Sclerosis Variant

Multiple Sclerosis Susceptibility To

Cerebrospinal Sclerosis

Generalised Multiple Sclerosis

Ms - [Multiple Sclerosis]

Disseminated Cerebrospinal Sclerosis

Disseminated Multiple Sclerosis

Disseminated Nervous System Myelosclerosis

Multiple Cerebrospinal Sclerosis

Multiple Combined Sclerosis

Multiple Sclerosis Generalised

Disseminated Brain Sclerosis

Disseminated Spinal Sclerosis

Insular Brain Sclerosis

Miliary Brain Sclerosis

Multiple Combined Sclerosis Of Spinal Cord

Multiple Ascending Sclerosis

Multiple Brain Sclerosis

Multiple Sclerosis Of Brain Stem

Multiple Sclerosis Of The Brain Stem

Multiple Sclerosis Of Cord

Sclérose En Plaques

Plaque Sclerosis

Multiple Sclerosis Of The Spinal Cord
Progressive Multifocal Leukoencephalopathy

Pml

Leukoencephalopathy, Progressive Multifocal

Progressive Multifocal Leukoencephalitis

Leukoencephalopathy Progressive Multifocal

Pml - [Progressive Multifocal Leukoencephalopathy]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (5)
目录号 产品名 作用方式
纯度 是否罕见病
HY-12355 Siponimod Agonist 99.95% 否
HY-12288 Ozanimod Agonist 99.88% 是
HY-10569 Ponesimod Agonist 99.81% 是
HY-12288A Ozanimod hydrochloride Modulator 99.19% 是
HY-12355A Siponimod hemifumarate Agonist / 否
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-17606 Cenerimod Agonist 99.43% Phase 3
HY-115831 SAR247799 Agonist 97.21% Phase 1
Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W008947 SEW​2871 Agonist 99.77% 否
HY-136578 RP101988 Agonist 98.92% 否
HY-111253 CYM-5478 Agonist 99.90% 否
HY-147660 IMMH001 Agonist 98.10% 否
HY-113934 L-threo Lysosphingomyelin (d18:1) Agonist ≥98.0% 否
HY-136576 RP101075 Agonist / 否
HY-108492 TC-SP 14 Agonist / 否
HY-158417 KSI-6666 Antagonist / 否
HY-119245 Udifitimod Modulator / 否
HY-136577 RP101442 Agonist / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris S1PR1 VGNC VGNC:45836
Mus musculus S1PR1 MGD MGI:1096355
Rattus norvegicus S1PR1 RGD RGD:61958
Macaca mulatta S1PR1 VGNC VGNC:100129
Bos taurus S1PR1 VGNC VGNC:34252
Felis catus S1PR1 VGNC VGNC:64845
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