Cdk5 - cyclin-dependent kinase 5 Gene

中文名称：细胞周期蛋白依赖性激酶 5

种属: Rattus norvegicus

关于 Cdk5

功能概要

该基因编码的蛋白可启动多种功能，包括肝配蛋白受体结合活性；蛋白激酶活性；电压门控钙通道活动参与突触前细胞溶质钙水平的正调节。参与多个过程，包括对淀粉样蛋白-β 的细胞反应；凋亡过程的正调控；和蛋白质磷酸化。作用于蛋白质磷酸化的上游或内部。位于多个细胞成分中，包括生长锥；神经细胞体；和突触后密度。蛋白激酶 5 复合体的一部分。活跃于多种细胞成分，包括 Schaffer 侧支 - CA1 突触；谷氨酸能突触；和神经肌肉接头。与微管共定位。用于研究脑缺血；精神抑郁症；和三叉神经痛。阿尔茨海默病的生物标志物；短暂性脑缺血；和血管性痴呆。该基因的人类直系同源物与阿尔茨海默氏病和伴有小脑发育不全的无脑畸形 7 有关。与人 CDK5（细胞周期蛋白依赖性激酶 5）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including Ephrin Receptor binding activity; protein kinase activity; and voltage-gated Calcium Channel activity involved in positive regulation of presynaptic cytosolic calcium levels. Involved in several processes, including cellular response to amyloid-beta; positive regulation of apoptotic process; and protein phosphorylation. Acts upstream of or within protein phosphorylation. Located in several cellular components, including growth cone; neuronal cell body; and postsynaptic density. Part of protein kinase 5 complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and neuromuscular junction. Colocalizes with microtubule. Used to study brain ischemia; mental depression; and trigeminal neuralgia. Biomarker of Alzheimer's disease; transient cerebral ischemia; and vascular dementia. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly 7 with cerebellar hypoplasia. Orthologous to human CDK5 (cyclin dependent kinase 5). [provided by Alliance of Genome Resources, Apr 2022]