2. Gene
  3. Cdk5 - cyclin-dependent kinase 5 Gene

Cdk5 - cyclin-dependent kinase 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：细胞周期蛋白依赖性激酶 5

种属: Rattus norvegicus

基因 ID: 140908 | 基因类型: protein coding

关于 Cdk5

Primary_assembly 4: 10,754,687-10,760,112 forward strand.mRatBN7.2:CM026977.1

This gene has 2 transcripts (splice variants), 170 orthologues, 24 paralogues and is associated with 16 phenotypes. Biased expression in Brain (RPKM 242.9), Adrenal (RPKM 12.7) and 9 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括肝配蛋白受体结合活性；蛋白激酶活性；电压门控钙通道活动参与突触前细胞溶质钙水平的正调节。参与多个过程，包括对淀粉样蛋白-β 的细胞反应；凋亡过程的正调控；和蛋白质磷酸化。作用于蛋白质磷酸化的上游或内部。位于多个细胞成分中，包括生长锥；神经细胞体；和突触后密度。蛋白激酶 5 复合体的一部分。活跃于多种细胞成分，包括 Schaffer 侧支 - CA1 突触；谷氨酸能突触；和神经肌肉接头。与微管共定位。用于研究脑缺血；精神抑郁症；和三叉神经痛。阿尔茨海默病的生物标志物；短暂性脑缺血；和血管性痴呆。该基因的人类直系同源物与阿尔茨海默氏病和伴有小脑发育不全的无脑畸形 7 有关。与人 CDK5（细胞周期蛋白依赖性激酶 5）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including Ephrin Receptor binding activity; protein kinase activity; and voltage-gated Calcium Channel activity involved in positive regulation of presynaptic cytosolic calcium levels. Involved in several processes, including cellular response to amyloid-beta; positive regulation of apoptotic process; and protein phosphorylation. Acts upstream of or within protein phosphorylation. Located in several cellular components, including growth cone; neuronal cell body; and postsynaptic density. Part of protein kinase 5 complex. Is active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and neuromuscular junction. Colocalizes with microtubule. Used to study brain ischemia; mental depression; and trigeminal neuralgia. Biomarker of Alzheimer's disease; transient cerebral ischemia; and vascular dementia. Human ortholog(s) of this gene implicated in Alzheimer's disease and lissencephaly 7 with cerebellar hypoplasia. Orthologous to human CDK5 (cyclin dependent kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Cdk5 基因产物(1)

mRNA Protein Name
NM_080885.2 NP_543161.1 cyclin-dependent kinase 5

Cdk5 蛋白结构

STKc_CDK5

STKc_CDK5: cd07839 (2 - 285)

  • 0
  • 100
  • 200
  • 292 a.a.
蛋白主名 其他名称

cyclin-dependent kinase 5

TPKII catalytic subunit

cell division protein kinase 5

cyclin-dependent-like kinase 5

serine/threonine-protein kinase PSSALRE

tau protein kinase II catalytic subunit

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-16297A Abemaciclib Inhibitor 99.94% 是
HY-10492 Dinaciclib Inhibitor 99.36% 是
HY-16297 Abemaciclib methanesulfonate Inhibitor 99.95% 是
Clinical Phase
生物活性分子 (14)
目录号 产品名 作用方式
纯度 Phase
HY-10580 GSK 3 Inhibitor IX Inhibitor 99.74% Phase 4
HY-30237 (R)-Roscovitine Inhibitor 99.84% Phase 2
HY-50940 AT7519 Inhibitor 99.76% Phase 2
HY-103712A Samuraciclib hydrochloride Inhibitor 99.98% Phase 2
HY-112272A Lerociclib dihydrochloride Inhibitor 98.11% Phase 2
HY-103712B Samuraciclib hydrochloride hydrate Inhibitor 99.08% Phase 2
HY-50943 AT7519 Hydrochloride Inhibitor 99.42% Phase 2
HY-112272 Lerociclib Inhibitor 98.35% Phase 2
HY-10012 AZD-5438 Inhibitor 99.85% Phase 1
HY-11001 PHA-793887 Inhibitor 99.25% Phase 1
HY-12871B Atuveciclib Inhibitor 99.80% Phase 1
HY-15504 RGB-286638 Inhibitor 99.70% Phase 1
HY-15504A RGB-286638 free base Inhibitor 98.07% Phase 1
HY-50940A AT7519 TFA Inhibitor 98.53% Phase 1
Pre-clinical Phase
生物活性分子 (58)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12302 Kenpaullone Inhibitor 98.20% 否
HY-15154 NG 52 Inhibitor 99.97% 否
HY-18340 (R)​-​CR8 Inhibitor 99.61% 否
HY-11009 CGP60474 Inhibitor 99.23% 否
HY-18299A Purvalanol A Inhibitor 98.30% 否
HY-10014 R547 Inhibitor 99.57% 否
HY-13266A BS-181 hydrochloride Inhibitor 99.80% 否
HY-13461A PHA-767491 hydrochloride Inhibitor 98.06% 否
HY-18340A (R)-CR8 trihydrochloride Inhibitor 98.95% 否
HY-18299 Purvalanol B Inhibitor ≥97.0% 否
HY-123772 CDK5 inhibitor 20-223 Inhibitor 99.78% 否
HY-12280 THZ2 Inhibitor 99.03% 否
HY-X0150 JSH-150 Inhibitor 98.36% 否
HY-144117 GFB-12811 Inhibitor 98.00% 否
HY-119940 MC180295 Inhibitor 98.89% 否
HY-145694 CDK5-IN-3 Inhibitor 98.00% 否
HY-W011428 Olomoucine Inhibitor 99.78% 否
HY-108359 Alsterpaullone Inhibitor 99.85% 否
HY-103221 MeBIO Inhibitor ≥98.0% 否
HY-107419 NU6140 Inhibitor 99.07% 否
HY-15241 NVP-LCQ195 Inhibitor 98.81% 否
HY-112358 GW8510 Inhibitor 99.64% 否
HY-154851 GSK-3 inhibitor 3 Inhibitor 98.72% 否
HY-117025A Manzamine A hydrochloride Inhibitor 99.66% 否
HY-103712C Samuraciclib hydrochloride hydrate Inhibitor 99.88% 否
HY-112468 PNU112455A hydrochloride Inhibitor 99.56% 否
HY-111930 5-Iodo-indirubin-3'-monoxime Inhibitor 99.50% 否
HY-121035 7BIO Inhibitor 99.20% 否
HY-N12625 (R)-(+)-O-Demethylbuchenavianine Inhibitor 98.67% 否
HY-103383 (R)-DRF053 dihydrochloride Inhibitor 99.30% 否
HY-13266 BS-181 Inhibitor 98.10% 否
HY-136726 CGP-82996 Inhibitor 98.12% 否
HY-114903 (E/Z)-BIO-acetoxime Inhibitor / 否
HY-103381 NSC693868 Inhibitor ≥99.0% 否
HY-X0009A JSH-009 dimaleate Inhibitor / 否
HY-117025 Manzamine A Inhibitor / 否
HY-14372 BS-194 Inhibitor 99.36% 否
HY-13461 PHA-767491 Inhibitor / 否
HY-151409 CDK1-IN-5 Inhibitor / 否
HY-151407 CDK1-IN-3 Inhibitor / 否
HY-110368 BS-181 dihydrochloride Inhibitor / 否
HY-103712 Samuraciclib Inhibitor / 否
HY-150641 CDK-IN-9 Inhibitor / 否
HY-145693 CDK5-IN-2 Inhibitor / 否
HY-112363 Aloisine A Inhibitor / 否
HY-142696 CDK6/PIM1-IN-1 Inhibitor / 否
HY-151408 CDK1-IN-4 Inhibitor / 否
HY-139725 CDK5-IN-1 Inhibitor 98.47% 否
HY-161595 CDK5-IN-4 Inhibitor / 否
HY-154852 GSK-3 inhibitor 4 Inhibitor / 否
HY-151878 CDK7-IN-20 Inhibitor / 否
HY-163856 CDK7-IN-30 Inhibitor / 否
HY-112336 Aloisine RP106 Inhibitor / 否
HY-161463 CDK2-IN-28 Inhibitor / 否
HY-112403 (S)-Roscovitine Inhibitor / 否
HY-123045 PNU-292137 Inhibitor / 否
HY-111932 Indirubin-5-sulfonate Inhibitor / 否
HY-111931 Indirubin-3'-monoxime-5-sulphonic acid Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cdk5 NCBI NCBI:1020
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