Flt1 - FMS-like tyrosine kinase 1 Gene

中文名称：fms 样酪氨酸激酶1

种属: Mus musculus

同用名: Flt-1; sFlt1; VEGFR1; VEGFR-1

基因 ID: 14254 | 基因类型: protein coding

关于 Flt1

Chromosome 5: 147,498,414-147,662,821 reverse strand.GRCm39:CM000998.3

This gene has 6 transcripts (splice variants), 199 orthologues, 53 paralogues and is associated with 24 phenotypes. Biased expression in placenta adult (RPKM 35.7), lung adult (RPKM 11.8) and 11 other tissues.

功能概要

实现相同的蛋白质结合活性和血管内皮生长因子激活受体活性。涉及多个过程，包括血管形态发生；胚胎形态发生；和透明体血管丛退化。作用于多个过程的上游或内部，包括血管生成；造血祖细胞分化的正调控；和胚胎后相机型眼睛形态发生。位于细胞外间隙和细胞核内。以多种结构表达，包括消化系统；心血管系统;中枢神经系统;胚外成分；和泌尿生殖系统。该基因的人类直系同源物与 Kuhnt-Junius 退化有关；糖尿病性视网膜病变;和先兆子痫。与人类 FLT1（fms 相关受体酪氨酸激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables identical protein binding activity and vascular endothelial growth factor-activated receptor activity. Involved in several processes, including blood vessel morphogenesis; embryonic morphogenesis; and hyaloid vascular plexus regression. Acts upstream of or within several processes, including angiogenesis; positive regulation of hematopoietic progenitor cell differentiation; and post-embryonic camera-type eye morphogenesis. Located in extracellular space and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; extraembryonic component; and genitourinary system. Human ortholog(s) of this gene implicated in Kuhnt-Junius degeneration; diabetic retinopathy; and pre-eclampsia. Orthologous to human FLT1 (fms related receptor tyrosine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Flt1 基因产物(2)

mRNA	Protein	Name
NM_001363135.1	NP_001350064.1	vascular endothelial growth factor receptor 1 isoform 2 precursor
NM_010228.4	NP_034358.2	vascular endothelial growth factor receptor 1 isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables identical protein binding	IPI IPI: 通过物理相互作用推断	11591653	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	25893857	MGI
enables vascular endothelial growth factor receptor activity	IDA IDA: 通过直接分析推断	8356051	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within angiogenesis	IMP IMP: 通过突变表型推断	14982871	MGI
involved in blood vessel morphogenesis	IMP IMP: 通过突变表型推断	7596436	MGI
acts upstream of or within branching involved in blood vessel morphogenesis	IMP IMP: 通过突变表型推断	14982871	MGI
acts upstream of or within cell migration	IGI IGI: 通过遗传相互作用推断	15601856	MGI
involved in cell migration	IMP IMP: 通过突变表型推断	9689083	MGI
involved in embryonic morphogenesis	IMP IMP: 通过突变表型推断	7596436	MGI
involved in hyaloid vascular plexus regression	IMP IMP: 通过突变表型推断	30936473	MGI
acts upstream of or within positive regulation of hematopoietic progenitor cell differentiation	IMP IMP: 通过突变表型推断	18772315	MGI
acts upstream of or within post-embryonic camera-type eye morphogenesis	IGI IGI: 通过遗传相互作用推断	22426483	MGI
acts upstream of or within response to hypoxia	IMP IMP: 通过突变表型推断	18772315	MGI
acts upstream of or within sprouting angiogenesis	IMP IMP: 通过突变表型推断	19758562	MGI
acts upstream of or within vascular endothelial growth factor receptor signaling pathway	IMP IMP: 通过突变表型推断	9689083	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	25184477	MGI
located in nucleus	IDA IDA: 通过直接分析推断	22886301	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Flt1 蛋白结构

Ig_3

IGc2

I-set

PKc_like

0
300
600
900
1200
1333 a.a.

蛋白主名

其他名称

vascular endothelial growth factor receptor 1

embryonic receptor kinase 2	tyrosine-protein kinase receptor FLT
vascular permeability factor receptor

重组 Flt1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P73553	VEGFR-1 Protein, Mouse (HEK293, His)	P35969/NP_034358.2 (Y23-E759)	≥95%

目录号	产品名	作用方式	纯度	是否罕见病
HY-16749	Pexidartinib		99.64%	是
HY-16749A	Pexidartinib hydrochloride		99.86%	是

目录号	产品名	作用方式	纯度	Phase
HY-50751	Linifanib		99.28%	Phase 3
HY-10205	Cediranib		99.58%	Phase 3
HY-10517	Orantinib		99.21%	Phase 3
HY-13049	Cediranib maleate		99.95%	Phase 3
HY-50751G	Linifanib (GMP)	Inhibitor	/	Phase 3
HY-110272	Vatalanib succinate	Inhibitor	/	Phase 3
HY-10204	OSI-930		98.57%	Phase 1
HY-100315	XL 999	Inhibitor	99.34%	Phase 1

目录号	产品名	作用方式	纯度	Phase
HY-P99364	Icrucumab	Inhibitor	95.00%	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-145293	TNIK-IN-3	Inhibitor	99.88%	否
HY-101219	VEGFR-IN-1	Inhibitor	98.42%	否
HY-15813	FIIN-1	Inhibitor	99.11%	否
HY-168114	Multi-kinase inhibitor 3	Inhibitor	/	否
HY-168115	Multi-kinase inhibitor 4	Inhibitor	/	否
HY-P10831	GNQWFI	Antagonist	/	否
HY-RS04987	FLT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS04988	Flt1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS04989	Flt1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P990541	Anti-VEGFR1/FLT1 Antibody	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Flt1	NCBI	NCBI:2321
Rattus norvegicus	Flt1	NCBI	NCBI:54251

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Flt1 - FMS-like tyrosine kinase 1 Gene

关于 Flt1

功能概要

Flt1 基因产物(2)

Flt1 蛋白结构

重组 Flt1 蛋白

直系同源

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Flt1 - FMS-like tyrosine kinase 1 Gene

关于 Flt1

功能概要

Flt1 基因产物(2)

Flt1 蛋白结构

重组 Flt1 蛋白

相关产品

直系同源

热门区域

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C

F

G

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J

L

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Q

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