2. Gene
  3. Flt4 - FMS-like tyrosine kinase 4 Gene

Flt4 - FMS-like tyrosine kinase 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：fms 样酪氨酸激酶4

种属: Mus musculus

同用名: Chy; Flt-4; VEGFR3; VEGFR-3

基因 ID: 14257 | 基因类型: protein coding

关于 Flt4

Chromosome 11: 49,500,090-49,543,566 forward strand.GRCm39:CM001004.3

This gene has 2 transcripts (splice variants), 196 orthologues, 53 paralogues and is associated with 27 phenotypes. Broad expression in lung adult (RPKM 14.6), ovary adult (RPKM 1.5) and 23 other tissues.

功能概要

该基因编码的蛋白可启动血管内皮生长因子激活受体活性。参与淋巴管生成；调节血管重塑；和发芽的血管生成。作用于肺泡发育的上游或内部；细胞群增殖的正向调节；和呼吸系统过程。预测位于胞质溶胶中；核质；和质膜。预计是受体复合体的一部分。预计是质膜的组成部分。以多种结构表达，包括消化系统；鳃弓;心血管系统;中枢神经系统;和胚外成分。用于研究遗传性淋巴水肿。该基因的人类直系同源物与遗传性淋巴水肿 IA 有关。与人类 FLT4（fms 相关受体酪氨酸激酶 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables vascular endothelial growth factor-activated receptor activity. Involved in lymphangiogenesis; regulation of blood vessel remodeling; and sprouting angiogenesis. Acts upstream of or within lung alveolus development; positive regulation of cell population proliferation; and respiratory system process. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including alimentary system; branchial arch; cardiovascular system; central nervous system; and extraembryonic component. Used to study hereditary lymphedema. Human ortholog(s) of this gene implicated in hereditary lymphedema IA. Orthologous to human FLT4 (fms related receptor tyrosine kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Flt4 基因产物(1)

mRNA Protein Name
NM_008029.3 NP_032055.1 vascular endothelial growth factor receptor 3 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9247316 MGI
enables vascular endothelial growth factor receptor activity IGI
IGI: 通过遗传相互作用推断
9247316 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in blood vessel morphogenesis IMP
IMP: 通过突变表型推断
9794766 MGI
acts upstream of or within lung alveolus development IMP
IMP: 通过突变表型推断
24733830 MGI
acts upstream of or within lymph vessel development IGI
IGI: 通过遗传相互作用推断
20439428 MGI
involved in lymph vessel development IMP
IMP: 通过突变表型推断
19903896 MGI
involved in lymphangiogenesis IMP
IMP: 通过突变表型推断
20697430 MGI
acts upstream of or within positive regulation of cell population proliferation IGI
IGI: 通过遗传相互作用推断
9247316 MGI
involved in regulation of blood vessel remodeling IMP
IMP: 通过突变表型推断
9794766 MGI
acts upstream of or within respiratory gaseous exchange by respiratory system IMP
IMP: 通过突变表型推断
24733830 MGI
acts upstream of or within respiratory system process IMP
IMP: 通过突变表型推断
24733830 MGI
involved in sprouting angiogenesis IMP
IMP: 通过突变表型推断
18594512 MGI
involved in vasculature development IMP
IMP: 通过突变表型推断
9794766 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Flt4 蛋白结构

IgI_VEGFR

IgI_VEGFR: cd05862 (229 - 328)

IgI_VEGFR

IgI_VEGFR: cd05862 (229 - 233)

IgI_VEGFR

IgI_VEGFR: cd05862 (239 - 243)

IgI_VEGFR

IgI_VEGFR: cd05862 (245 - 254)

IgI_VEGFR

IgI_VEGFR: cd05862 (261 - 266)

IgI_VEGFR

IgI_VEGFR: cd05862 (269 - 271)

IgI_VEGFR

IgI_VEGFR: cd05862 (275 - 283)

IgI_VEGFR

IgI_VEGFR: cd05862 (288 - 296)

IgI_VEGFR

IgI_VEGFR: cd05862 (306 - 312)

IgI_VEGFR

IgI_VEGFR: cd05862 (317 - 323)

Ig

Ig: cl11960 (330 - 417)

Ig

Ig: cd00096 (351 - 355)

Ig

Ig: cd00096 (364 - 368)

Ig

Ig: cd00096 (381 - 385)

Ig

Ig: cd00096 (395 - 400)

Ig

Ig: cd00096 (410 - 413)

IG_like

IG_like: smart00410 (569 - 662)

Ig

Ig: cd00096 (573 - 577)

Ig

Ig: cd00096 (586 - 590)

Ig

Ig: cd00096 (635 - 639)

Ig

Ig: cd00096 (649 - 654)

Ig

Ig: cl11960 (677 - 764)

Ig

Ig: cd00096 (694 - 698)

Ig

Ig: cd00096 (707 - 711)

Ig

Ig: cd00096 (730 - 734)

Ig

Ig: cd00096 (744 - 749)

VEGFR-2_TMD

VEGFR-2_TMD: pfam17988 (769 - 803)

PKc_like

PKc_like: cl21453 (836 - 1174)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1363 a.a.
蛋白主名 其他名称

vascular endothelial growth factor receptor 3

chylous ascites

receptor protein tyrosine kinase

tyrosine-protein kinase receptor FLT4

重组 Flt4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74466 VEGFR-3/FLT4 Protein, Mouse (HEK293, His) P35917 (Y25-E775) ≥95%
HY-P74467 VEGFR-3/FLT4 Protein, Mouse (HEK293, hFc) P35917 (Y25-E775) ≥95%

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10260 Vandetanib 99.95% 是
HY-10260B Vandetanib hydrochloride / 否
HY-10260A Vandetanib trifluoroacetate / 否
Clinical Phase
生物活性分子 (8)
目录号 产品名 作用方式
纯度 Phase
HY-10205 Cediranib 99.58% Phase 3
HY-100019 Rogaratinib Inhibitor 99.86% Phase 3
HY-13314 Tesevatinib Inhibitor 99.21% Phase 3
HY-13049 Cediranib maleate 99.95% Phase 3
HY-110272 Vatalanib succinate Inhibitor / Phase 3
HY-13034 Gandotinib Inhibitor 99.82% Phase 2
HY-10987A ENMD-2076 99.12% Phase 2
HY-10987 ENMD-2076 Tartrate 99.42% Phase 2
Pre-clinical Phase
生物活性分子 (13)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-116624 MAZ51 99.96% 否
HY-119933 RIPK1-IN-7 Inhibitor 98.56% 否
HY-145293 TNIK-IN-3 Inhibitor 99.88% 否
HY-15813 FIIN-1 Inhibitor 99.11% 否
HY-RS04994 FLT4 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-10260S Vandetanib-d6 / 否
HY-10260S1 Vandetanib-d4 / 否
HY-10260S2 Vandetanib-13C6 / 否
HY-155178 Antiproliferative agent-34 Inhibitor / 否
HY-168114 Multi-kinase inhibitor 3 Inhibitor / 否
HY-168115 Multi-kinase inhibitor 4 Inhibitor / 否
HY-RS04995 Flt4 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS04996 Flt4 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990620 LY3022856 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Flt4 NCBI NCBI:2324
Rattus norvegicus Flt4 NCBI NCBI:114110
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