KRT80 - keratin 80 Gene

中文名称：角蛋白 80

种属: Homo sapiens

同用名: KB20

关于 KRT80

功能概要

角蛋白是负责上皮细胞结构完整性的中间丝蛋白，分为上皮角蛋白和毛发角蛋白。该基因的表达谱显示它编码 II 型上皮角蛋白，尽管在结构上编码的蛋白质更像是 II 型毛发角蛋白。这种蛋白质参与细胞分化，在分化的早期阶段定位在桥粒斑块附近，但随后在终末分化细胞中分散到整个细胞质中。 II 型角蛋白聚集在染色体 12q13 的区域。已为该基因发现编码两种不同全功能亚型的两种转录变体。[RefSeq 提供，2010 年 10 月]

Keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into epithelial keratins and hair keratins. This gene's expression profile shows that it encodes a type II epithelial keratin, although structurally the encoded protein is more like a type II hair keratin. This protein is involved in cell differentiation, localizing near desmosomal plaques in earlier stages of differentiation but then dispersing throughout the cytoplasm in terminally differentiating cells. The type II keratins are clustered in a region of chromosome 12q13. Two transcript variants encoding two different fully functional isoforms have been found for this gene.[provided by RefSeq, Oct 2010]