Gli1 - GLI-Kruppel family member GLI1 Gene

中文名称：GL I-Kruppel 家族成员 GL I1

种属: Mus musculus

同用名: Zfp5; Zfp-5

关于 Gli1

功能概要

该基因编码的蛋白可启动多种功能，包括 DNA 结合转录因子活性、RNA 聚合酶 II 特异性； RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性；和微管结合活性。参与成骨细胞分化的调节。作用于多个过程的上游或内部，包括动物器官发育；参与细胞间信号传导的细胞表面受体信号通路；和区域化。位于轴丝和细胞核。以多种结构表达，包括消化系统；中枢神经系统;胚胎间充质；长骨;和感觉器官。与人类 GLI1（GLI 家族锌指 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and microtubule binding activity. Involved in regulation of osteoblast differentiation. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway involved in cell-cell signaling; and regionalization. Located in axoneme and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; long bone; and sensory organ. Orthologous to human GLI1 (Gli family zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]