CTSZ - cathepsin Z Gene

中文名称：组织蛋白酶 Z

种属: Homo sapiens

同用名: CTSX

基因 ID: 1522 | 基因类型: protein coding

关于 CTSZ

Cytogenetic location: 20q13.32 Genomic coordinates (GRCh38): 20:58,995,185-59,007,254 (from NCBI)

This gene has 32 transcripts (splice variants), 234 orthologues and 12 paralogues. Ubiquitous expression in lymph node (RPKM 146.3), appendix (RPKM 144.2) and 25 other tissues.

功能概要

该基因编码的蛋白质是一种溶酶体半胱氨酸蛋白酶，是肽酶 C1 家族的成员。它表现出羧基单肽酶和羧基二肽酶活性。编码的蛋白质也被称为组织蛋白酶 X 和组织蛋白酶 P。该基因在癌细胞系和原发性肿瘤中普遍表达，并且与该家族的其他成员一样，可能参与肿瘤发生。[RefSeq 提供，2008 年 10 月]

The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as Cathepsin X and Cathepsin P. This gene is expressed ubiquitously in Cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]

CTSZ 基因产物(1)

mRNA	Protein	Name
NM_001336.4	NP_001327.2	cathepsin Z preproprotein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables carboxypeptidase activity	IMP IMP: 通过突变表型推断	19433310	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21516116	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in negative regulation of plasminogen activation	IMP IMP: 通过突变表型推断	19433310	GOA
involved in proteolysis	IMP IMP: 通过突变表型推断	19433310	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell cortex	IDA IDA: 通过直接分析推断	19433310	GOA
located in cytoplasmic vesicle	IDA IDA: 通过直接分析推断	19433310	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	19433310	GOA
located in lysosome	IDA IDA: 通过直接分析推断	19433310	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

cathepsin Z

carboxypeptidase LB

重组 CTSZ 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7758	Cathepsin Z/CTSZ Protein, Human (HEK293, His, solution)	Q9UBR2 (G24-V303)	≥95%

关联疾病

疾病名称

别名

Cercarial Dermatitis

Swimmer'S Itch	Cutaneous Schistosomiasis
Sea Bather'S Eruption	Clam-Digger'S Itch
Rice-Paddy Itch	Sea Bather'S Itch
Sawah Itch	Schistosomal Cercarial Dermatitis

Mitochondrial Complex V Deficiency, Nuclear Type 5

Mitochondrial Complex V Deficiency	MC5DN5
Mitochondrial Complex V Deficiency, Atp5f1d Type	Mitochondrial Complex V Deficiency
Mitochondrial Complex 5 Deficiency Nuclear Type 5	Complex 5 Mitochondrial Respiratory Chain Deficiency
Atp Synthase Deficiency	Mitochondrial Complex V Deficiency, Nuclear Type 5
Complex V Deficiency

Neuronal Ceroid Lipofuscinosis

Hereditary Ceroid Lipofuscinosis	Batten Disease
Ncl	Neuronal Ceroid-Lipofuscinoses
Lipofuscinosis, Ceroid, Neuronal	Juvenile Neuronal Ceroid Lipofuscinosis
Cerebromacular Dystrophy	Cerebromacular Degeneration
Ceroid-Lipofuscinosis	Ncl - [Neuronal Ceroid Lipofuscinosis]
Amaurotic Familial Idiocy	Amaurotic Idiocy
Amaurotic Idiot	Neuronal Lipofuscinosis
Pigmentary Retinal Lipoid Neuronal Heredodegeneration

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03349	CTSZ Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	CTSZ	VGNC	VGNC:61273
Macaca mulatta	CTSZ	VGNC	VGNC:71564
Mus musculus	CTSZ	MGD	MGI:1891190
Rattus norvegicus	CTSZ	RGD	RGD:708479
Canis familiaris	CTSZ	VGNC	VGNC:39717
Bos taurus	CTSZ	VGNC	VGNC:27820
Others	CTSZ	NCBI

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