2. Gene
  3. Hgf - hepatocyte growth factor Gene

Hgf - hepatocyte growth factor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: SF; NK1; NK2; HGF/SF; SF/HGF; C230052L06Rik

基因 ID: 15234 | 基因类型: protein coding

关于 Hgf

功能概要

This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. The encoded preproprotein is proteolytically processed to generate multiple protein products, including the hepatocyte growth factor alpha and beta chains, which heterodimerize to form the mature active protein. Although this protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Homozygous knockout mice for this gene exhibit embryonic lethality due to impaired development of the placenta and liver. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

Hgf 基因产物(5)

mRNA Protein Name
NM_001289458.1 NP_001276387.1 hepatocyte growth factor isoform 1 preproprotein
NM_001289459.1 NP_001276388.1 hepatocyte growth factor isoform 1 preproprotein
NM_001289460.2 NP_001276389.1 hepatocyte growth factor isoform 2 precursor
NM_001289461.1 NP_001276390.1 hepatocyte growth factor isoform 3 preproprotein
NM_010427.5 NP_034557.3 hepatocyte growth factor isoform 1 preproprotein
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17804794 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cell morphogenesis IDA
IDA: 通过直接分析推断
12130561 MGI
acts upstream of or within epithelial cell proliferation IDA
IDA: 通过直接分析推断
12130561 MGI
acts upstream of or within hepatocyte growth factor receptor signaling pathway IDA
IDA: 通过直接分析推断
15314156 MGI
acts upstream of or within liver development IDA
IDA: 通过直接分析推断
16880525 MGI
acts upstream of or within myoblast proliferation IDA
IDA: 通过直接分析推断
11061428 MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway via death domain receptors IDA
IDA: 通过直接分析推断
15314156 MGI
acts upstream of or within negative regulation of inflammatory response IDA
IDA: 通过直接分析推断
21072211 MGI
acts upstream of or within negative regulation of interleukin-6 production IDA
IDA: 通过直接分析推断
21072211 MGI
acts upstream of or within negative regulation of peptidyl-serine phosphorylation IDA
IDA: 通过直接分析推断
21072211 MGI
acts upstream of or within positive regulation of MAPK cascade IDA
IDA: 通过直接分析推断
15314156 MGI
acts upstream of or within positive regulation of interleukin-10 production IDA
IDA: 通过直接分析推断
21072211 MGI
acts upstream of or within regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling IMP
IMP: 通过突变表型推断
14517989 MGI
acts upstream of or within regulation of p38MAPK cascade IDA
IDA: 通过直接分析推断
23994610 MGI
acts upstream of or within regulation of tau-protein kinase activity IDA
IDA: 通过直接分析推断
21072211 MGI
acts upstream of or within skeletal muscle cell proliferation IDA
IDA: 通过直接分析推断
11061428 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

hepatocyte growth factor

hepatopoietin-A

scatter factor

重组 Hgf 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70561 HGF Protein, Mouse (HEK293, His) Q08048-1 (Q33-L728) ≥95%
HY-P73928 HGF Protein, Mouse (HEK293) Q08048-1 (Q33-L728) ≥95%

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-A0020 Eldecalcitol 99.94% 是
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-137455 Terevalefim Activator 99.89% Phase 3
HY-18696 AMG-337 99.43% Phase 2
抗体抑制剂 (4)
目录号 产品名 作用方式
纯度 Phase
HY-P99250 Onartuzumab Inhibitor 99.62% Phase 3
HY-P99196 Ficlatuzumab Inhibitor 99.21% Phase 3
HY-P99217 Rilotumumab Inhibitor 99.10% Phase 3
HY-P99192 Emibetuzumab Inhibitor 95.00% Phase 2
Pre-clinical Phase
生物活性分子 (14)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-116282D Dextran sulfate sodium salt (MW 450000-550000) / 否
HY-16969 Dihexa Activator 99.21% 否
HY-114363A SRI 31215 TFA Inhibitor 98.53% 否
HY-106961 ONO 1301 Agonist 99.06% 否
HY-W014940 Ethylene glycol dimethacrylate 99.52% 否
HY-P1415A Norleual TFA 99.32% 否
HY-154988 MARK4 inhibitor 4 99.23% 否
HY-145263 VD2173 Inhibitor / 否
HY-N13286 Glycozolidal Inhibitor 99.92% 否
HY-10338A Foretinib phosphate Inhibitor / 否
HY-106961A (Z)-ONO 1301 / 否
HY-120159 GS-493 Inhibitor / 否
HY-P1415 Norleual / 否
HY-RS06152 HGF Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hgf NCBI NCBI:3082
Canis familiaris Hgf NCBI NCBI:403441
Macaca fascicularis Hgf NCBI NCBI:102133907
Rattus norvegicus Hgf NCBI NCBI:24446
Macaca mulatta Hgf NCBI NCBI:708316
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z