Igf1r - insulin-like growth factor I receptor Gene

中文名称：胰岛素样生长因子 I 受体

种属: Mus musculus

同用名: hyft; CD221; IGF-1R; D930020L01; A330103N21Rik

基因 ID: 16001 | 基因类型: protein coding

关于 Igf1r

Chromosome 7: 67,602,575-67,883,416 forward strand.GRCm39:CM001000.3

This gene has 6 transcripts (splice variants), 276 orthologues, 53 paralogues and is associated with 37 phenotypes. Ubiquitous expression in limb E14.5 (RPKM 1.6), kidney adult (RPKM 1.1) and 27 other tissues.

功能概要

该基因编码的蛋白可启动胰岛素样生长因子结合活性。参与多个过程，包括肾上腺发育；冷诱导产热的正调节；和减数分裂细胞周期的正调控。作用于多个过程的上游或内部，包括腺体发育；肽基酪氨酸自磷酸化；和细胞内信号转导的调节。位于 T 管。是膜的组成部分。以多种结构表达，包括消化系统；脑;泌尿生殖系统；肢;和肺。该基因的人类直系同源物与多种疾病有关，包括痴呆症（多种）；肾癌（多发性）；肝病（多发性）；神经系统癌症（多发性）；和神经退行性疾病（多种）。与人类 IGF1R（胰岛素样生长因子 1 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables insulin-like growth factor binding activity. Involved in several processes, including adrenal gland development; positive regulation of cold-induced thermogenesis; and positive regulation of meiotic cell cycle. Acts upstream of or within several processes, including gland development; peptidyl-tyrosine autophosphorylation; and regulation of intracellular signal transduction. Located in T-tubule. Is integral component of membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and lung. Human ortholog(s) of this gene implicated in several diseases, including dementia (multiple); kidney Cancer (multiple); liver disease (multiple); nervous system Cancer (multiple); and neurodegenerative disease (multiple). Orthologous to human IGF1R (Insulin like growth factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Igf1r 基因产物(1)

mRNA	Protein	Name
NM_010513.3	NP_034643.2	insulin-like growth factor 1 receptor precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables insulin-like growth factor binding	IPI IPI: 通过物理相互作用推断	14566968	MGI
enables insulin-like growth factor receptor activity	IDA IDA: 通过直接分析推断	19302825	MGI
enables insulin-like growth factor receptor activity	IGI IGI: 通过遗传相互作用推断	33567274	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	12771153	MGI
enables protein tyrosine kinase activity	IDA IDA: 通过直接分析推断	7799946	MGI
enables protein tyrosine kinase activity	IGI IGI: 通过遗传相互作用推断	9024787	MGI
enables protein tyrosine kinase activity	IMP IMP: 通过突变表型推断	12483226	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of MAPK cascade	IMP IMP: 通过突变表型推断	18451178	MGI
involved in adrenal gland development	IGI IGI: 通过遗传相互作用推断	23300479	MGI
acts upstream of or within animal organ morphogenesis	IMP IMP: 通过突变表型推断	12101187	MGI
acts upstream of or within brain development	IMP IMP: 通过突变表型推断	12904469	MGI
acts upstream of or within cellular response to glucose stimulus	IMP IMP: 通过突变表型推断	21677284	MGI
acts upstream of or within cellular response to insulin stimulus	IMP IMP: 通过突变表型推断	21677284	MGI
acts upstream of or within epidermis development	IMP IMP: 通过突变表型推断	23906066	MGI
acts upstream of or within exocrine pancreas development	IMP IMP: 通过突变表型推断	12101187	MGI
involved in insulin-like growth factor receptor signaling pathway	IDA IDA: 通过直接分析推断	29348399	MGI
involved in insulin-like growth factor receptor signaling pathway	IGI IGI: 通过遗传相互作用推断	8402901	MGI
involved in insulin-like growth factor receptor signaling pathway	IMP IMP: 通过突变表型推断	12483226	MGI
acts upstream of or within male sex determination	IMP IMP: 通过突变表型推断	14628051	MGI
acts upstream of or within mammary gland development	IMP IMP: 通过突变表型推断	17662267	MGI
acts upstream of mitotic nuclear division	IMP IMP: 通过突变表型推断	23906066	MGI
acts upstream of or within negative regulation of DNA-binding transcription factor activity	IMP IMP: 通过突变表型推断	23906066	MGI
acts upstream of or within negative regulation of MAPK cascade	IMP IMP: 通过突变表型推断	18451178	MGI
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: 通过突变表型推断	18451178	MGI
acts upstream of or within peptidyl-tyrosine autophosphorylation	IDA IDA: 通过直接分析推断	10100151	MGI
acts upstream of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: 通过突变表型推断	18451178	MGI
involved in positive regulation of DNA-templated transcription	IGI IGI: 通过遗传相互作用推断	23300479	MGI
acts upstream of or within positive regulation of MAPK cascade	IMP IMP: 通过突变表型推断	18451178	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: 通过突变表型推断	26910308	MGI
involved in positive regulation of developmental growth	IMP IMP: 通过突变表型推断	23300479	MGI
involved in positive regulation of meiotic cell cycle	IGI IGI: 通过遗传相互作用推断	23300479	MGI
acts upstream of or within positive regulation of mitotic nuclear division	IMP IMP: 通过突变表型推断	23906066	MGI
acts upstream of or within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: 通过突变表型推断	18451178	MGI
involved in postsynaptic modulation of chemical synaptic transmission	EXP EXP: 通过实验结果推断	28683263	MGI
involved in postsynaptic modulation of chemical synaptic transmission	IDA IDA: 通过直接分析推断	28683263	MGI
acts upstream of or within prostate gland epithelium morphogenesis	IMP IMP: 通过突变表型推断	18451178	MGI
acts upstream of or within protein phosphorylation	IDA IDA: 通过直接分析推断	18216249	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in T-tubule	IDA IDA: 通过直接分析推断	23695157	MGI
is active in glutamatergic synapse	EXP EXP: 通过实验结果推断	28683263	MGI
is active in glutamatergic synapse	IDA IDA: 通过直接分析推断	28683263	MGI
located in membrane	IDA IDA: 通过直接分析推断	7931420	MGI
located in plasma membrane	IDA IDA: 通过直接分析推断	18451178	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Igf1r 蛋白结构

Recep_L_domain

Furin-like

Recep_L_domain

FN3

PTKc_InsR_like

0
300
600
900
1200
1369 a.a.

蛋白主名

其他名称

insulin-like growth factor 1 receptor

IGF-I receptor

line 186

重组 Igf1r 蛋白

目录号	产品名	蛋白编号	纯度
HY-P78723	IGF-I R Protein, Mouse (HEK293, His)	Q60751-1 (E31-H936)	≥95%

相关产品

Approval

生物活性分子 (3)

目录号	产品名	作用方式	纯度	是否罕见病
HY-15656	Ceritinib	Inhibitor	99.98%	是
HY-15656A	Ceritinib dihydrochloride	Inhibitor	99.57%	是
HY-B0025	Voglibose	Inhibitor	≥98.0%	否

抗体抑制剂 (1)

目录号	产品名	作用方式	纯度	是否罕见病
HY-P99165	Teprotumumab	Inhibitor	99.46%	否

Clinical Phase

生物活性分子 (6)

目录号	产品名	作用方式	纯度	Phase
HY-15494	Picropodophyllin		99.85%	Phase 2
HY-10200	BMS-754807	Inhibitor	99.41%	Phase 2
HY-15749	XL228	Inhibitor	99.64%	Phase 1
HY-B0794B	AZ7550 Mesylate	Inhibitor	99.24%	Phase 1
HY-13326	ASP3026		99.88%	Phase 1
HY-B0794A	AZ7550 hydrochloride	Inhibitor	98.66%	Phase 1

抗体抑制剂 (6)

目录号	产品名	作用方式	纯度	Phase
HY-P99294	Ganitumab	Inhibitor	96.00%	Phase 3
HY-P99197	Figitumumab	Inhibitor	96.89%	Phase 3
HY-P99284	Dalotuzumab		97.43%	Phase 2
HY-P99218	Robatumumab	Inhibitor	99.90%	Phase 2
HY-P99712	Lonigutamab	Inhibitor	95.00%	Phase 2
HY-P99672	Istiratumab	Inhibitor	/	Phase 2

Pre-clinical Phase

生物活性分子 (33)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-116624	MAZ51		99.96%	否
HY-50866	NVP-AEW541		99.92%	否
HY-10262	BMS-536924		99.83%	否
HY-15609	AZD-3463		99.58%	否
HY-10252	NVP-ADW742		99.54%	否
HY-N0908	Ginsenoside Rg5		99.87%	否
HY-10253	AG1024		98.86%	否
HY-10524	GSK1904529A		98.89%	否
HY-13203	NVP-TAE 226		99.77%	否
HY-100349	SU4312	Inhibitor	99.76%	否
HY-18785	Indirubin Derivative E804	Inhibitor	98.54%	否
HY-145110	IGF-1R inhibitor-2	Inhibitor	98.36%	否
HY-135680	I-OMe-Tyrphostin AG 538	Inhibitor	98.03%	否
HY-B0794	AZ7550	Inhibitor	/	否
HY-125102	AZ12253801	Inhibitor	/	否
HY-50866B	NVP-AEW541 dihydrochloride		/	否
HY-108230	ALK-IN-12	Inhibitor	/	否
HY-118046	GSK2163632A	Inhibitor	/	否
HY-15494S1	Picropodophyllin-d6		/	否
HY-156914	IGF-1R/SRC-IN-1	Inhibitor	99.86%	否
HY-162506	IGF-1R inhibitor-3	Inhibitor	/	否
HY-167854	KW-2450 free base		/	否
HY-402309	IGF-1R modulator 1	Modulator	/	否
HY-B0794S	AZ7550-d5	Inhibitor	/	否
HY-RS06615	IGF1R Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06616	Igf1r Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06617	Igf1r Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-100349A	cis-SU4312	Inhibitor	/	否
HY-14357	BMS 695735	Inhibitor	/	否
HY-168616	CL-A3-7	Inhibitor	/	否
HY-21291	SU-4313	Modulator	/	否
HY-N6611	Chimaphilin	Inhibitor	/	否
HY-P3226	JB-1	Antagonist	/	否

抗体抑制剂 (1)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P990084	Veligrotug	Inhibitor	99.25%	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Igf1r	NCBI	NCBI:3480
Macaca fascicularis	Igf1r	NCBI	NCBI:102130142
Rattus norvegicus	Igf1r	NCBI	NCBI:25718

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4