Igf1r - insulin-like growth factor 1 receptor Gene

中文名称：胰岛素样生长因子1 受体

种属: Rattus norvegicus

同用名: Igfr1; JTK13; IGFIRC; IGF-1 receptor

基因 ID: 25718 | 基因类型: protein coding

关于 Igf1r

Primary_assembly 1: 121,550,743-121,831,777 forward strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 276 orthologues, 54 paralogues and is associated with 88 phenotypes. Biased expression in Adrenal (RPKM 154.5), Kidney (RPKM 119.) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 G 蛋白 α-亚基结合活性；胰岛素受体底物结合活性；和胰岛素样生长因子激活受体活性。参与多个过程，包括细胞对激素刺激的反应；细胞凋亡过程的负调控；和神经系统发育。位于多个细胞成分中，包括 T 管；小窝;和神经细胞体。用于研究老年痴呆症；帕金森病；和前列腺癌。几种疾病的生物标志物，包括酒精性神经病；动脉疾病（多发性）；隐睾;糖尿病（多发性）；和神经退行性疾病（多种）。该基因的人类直系同源基因与多种疾病有关，包括 IgA 肾小球肾炎；痴呆症（多发）；肾癌（多发性）；肝病（多发性）；和神经系统癌症（多种）。与人类 IGF1R（胰岛素样生长因子 1 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables G-protein alpha-subunit binding activity; Insulin Receptor substrate binding activity; and insulin-like growth factor-activated receptor activity. Involved in several processes, including cellular response to hormone stimulus; negative regulation of apoptotic process; and nervous system development. Located in several cellular components, including T-tubule; caveola; and neuronal cell body. Used to study Alzheimer's disease; Parkinson's disease; and prostate adenocarcinoma. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); cryptorchidism; diabetes mellitus (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney Cancer (multiple); liver disease (multiple); and nervous system Cancer (multiple). Orthologous to human IGF1R (Insulin like growth factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Igf1r 基因产物(2)

mRNA	Protein	Name
NM_001414181.1	NP_001401110.1	insulin-like growth factor 1 receptor isoform 1 precursor
NM_052807.3	NP_434694.1	insulin-like growth factor 1 receptor isoform 2 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables G-protein alpha-subunit binding	IPI IPI: 通过物理相互作用推断	19764351	RGD
enables insulin receptor substrate binding	IPI IPI: 通过物理相互作用推断	15272025	RGD
enables insulin-like growth factor receptor activity	IDA IDA: 通过直接分析推断	16909201	RGD
enables protein binding	IPI IPI: 通过物理相互作用推断	11423532	RGD
enables protein tyrosine kinase activity	IDA IDA: 通过直接分析推断	16909201	RGD
enables protein-containing complex binding	IDA IDA: 通过直接分析推断	15272025	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in axonogenesis	IMP IMP: 通过突变表型推断	16845384	RGD
involved in cardiac atrium development	IEP IEP: 通过表达模式推断	15486038	RGD
involved in cellular response to aldosterone	IEP IEP: 通过表达模式推断	22173225	RGD
involved in cellular response to angiotensin	IEP IEP: 通过表达模式推断	8579617	RGD
involved in cellular response to dexamethasone stimulus	IEP IEP: 通过表达模式推断	19853640	RGD
involved in cellular response to estradiol stimulus	IEP IEP: 通过表达模式推断	10650946	RGD
involved in cellular response to glucose stimulus	IEP IEP: 通过表达模式推断	20633551	RGD
involved in cellular response to insulin stimulus	IEP IEP: 通过表达模式推断	20013160	RGD
involved in cellular response to insulin-like growth factor stimulus	IEP IEP: 通过表达模式推断	23349896	RGD
involved in cellular response to insulin-like growth factor stimulus	IPI IPI: 通过物理相互作用推断	12837295	RGD
involved in cellular response to mechanical stimulus	IEP IEP: 通过表达模式推断	21854769	RGD
involved in cellular response to progesterone stimulus	IEP IEP: 通过表达模式推断	19853640	RGD
involved in cellular response to testosterone stimulus	IEP IEP: 通过表达模式推断	10650946	RGD
involved in cellular response to transforming growth factor beta stimulus	IPI IPI: 通过物理相互作用推断	12837295	RGD
involved in cellular response to zinc ion starvation	IEP IEP: 通过表达模式推断	21893222	RGD
involved in cellular senescence	IEP IEP: 通过表达模式推断	19862643	RGD
involved in cerebellum development	IEP IEP: 通过表达模式推断	23397157	RGD
involved in cerebellum development	IMP IMP: 通过突变表型推断	21443795	RGD
involved in dendritic spine maintenance	IGI IGI: 通过遗传相互作用推断	19406747	RGD
involved in establishment of cell polarity	IMP IMP: 通过突变表型推断	16845384	RGD
involved in estrous cycle	IMP IMP: 通过突变表型推断	17567960	RGD
involved in hippocampus development	IEP IEP: 通过表达模式推断	22042446	RGD
involved in insulin receptor signaling pathway	IMP IMP: 通过突变表型推断	19406747	RGD
involved in negative regulation of cholangiocyte apoptotic process	IMP IMP: 通过突变表型推断	17531559	RGD
involved in negative regulation of hepatocyte apoptotic process	IMP IMP: 通过突变表型推断	17531559	RGD
involved in negative regulation of muscle cell apoptotic process	IMP IMP: 通过突变表型推断	19507001	RGD
involved in neuron projection development	IDA IDA: 通过直接分析推断	15567343	RGD
involved in positive regulation of DNA metabolic process	IMP IMP: 通过突变表型推断	19507001	RGD
involved in positive regulation of axon regeneration	IMP IMP: 通过突变表型推断	23349896	RGD
involved in positive regulation of cytokinesis	IMP IMP: 通过突变表型推断	19507001	RGD
involved in positive regulation of osteoblast proliferation	IMP IMP: 通过突变表型推断	15110779	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP IMP: 通过突变表型推断	25186839	RGD
involved in positive regulation of protein-containing complex disassembly	IGI IGI: 通过遗传相互作用推断	19406747	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: 通过突变表型推断	21854769	RGD
involved in positive regulation of steroid hormone biosynthetic process	IMP IMP: 通过突变表型推断	17023532	RGD
involved in response to L-glutamate	IDA IDA: 通过直接分析推断	18981172	RGD
involved in response to alkaloid	IEP IEP: 通过表达模式推断	30240970	RGD
involved in response to ethanol	IDA IDA: 通过直接分析推断	17645580	RGD
involved in response to ethanol	IEP IEP: 通过表达模式推断	24239160	RGD
involved in response to hormone	IEP IEP: 通过表达模式推断	30240970	RGD
involved in response to insulin	IEP IEP: 通过表达模式推断	19008912	RGD
involved in response to nicotine	IEP IEP: 通过表达模式推断	22265867	RGD
involved in response to nutrient levels	IEP IEP: 通过表达模式推断	21266509	RGD
involved in response to vitamin E	IEP IEP: 通过表达模式推断	17447016	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in T-tubule	IDA IDA: 通过直接分析推断	23118311	RGD
located in axon	IDA IDA: 通过直接分析推断	23349896	RGD
located in caveola	IDA IDA: 通过直接分析推断	18022157	RGD
located in neuronal cell body	IDA IDA: 通过直接分析推断	19862643	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Igf1r 蛋白结构

Recep_L_domain

Furin-like

Recep_L_domain

FN3

PTKc_InsR_like

0
300
600
900
1200
1372 a.a.

蛋白主名

其他名称

insulin-like growth factor 1 receptor

IGF-I receptor	insulin-like growth factor I receptor
type-I IGF receptor

重组 Igf1r 蛋白

目录号	产品名	蛋白编号	纯度
HY-P78724	IGF-I R Protein, Rat (HEK293, His)	P24062 (E31-H936)	≥95%

目录号	产品名	作用方式	纯度	是否罕见病
HY-15656	Ceritinib	Inhibitor	99.98%	是
HY-15656A	Ceritinib dihydrochloride	Inhibitor	99.57%	是
HY-B0025	Voglibose	Inhibitor	≥98.0%	否

目录号	产品名	作用方式	纯度	是否罕见病
HY-P99165	Teprotumumab	Inhibitor	99.46%	否

目录号	产品名	作用方式	纯度	Phase
HY-15494	Picropodophyllin		99.85%	Phase 2
HY-10200	BMS-754807	Inhibitor	99.41%	Phase 2
HY-15749	XL228	Inhibitor	99.64%	Phase 1
HY-B0794B	AZ7550 Mesylate	Inhibitor	99.24%	Phase 1
HY-13326	ASP3026		99.88%	Phase 1
HY-B0794A	AZ7550 hydrochloride	Inhibitor	98.66%	Phase 1

目录号	产品名	作用方式	纯度	Phase
HY-P99294	Ganitumab	Inhibitor	96.00%	Phase 3
HY-P99197	Figitumumab	Inhibitor	96.89%	Phase 3
HY-P99284	Dalotuzumab		97.43%	Phase 2
HY-P99189	Cixutumumab	Inhibitor	99.63%	Phase 2
HY-P99218	Robatumumab	Inhibitor	99.90%	Phase 2
HY-P99712	Lonigutamab	Inhibitor	95.00%	Phase 2
HY-P99672	Istiratumab	Inhibitor	/	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-116624	MAZ51		99.96%	否
HY-50866	NVP-AEW541		99.92%	否
HY-10262	BMS-536924		99.83%	否
HY-15609	AZD-3463		99.58%	否
HY-10252	NVP-ADW742		99.54%	否
HY-N0908	Ginsenoside Rg5		99.87%	否
HY-10253	AG1024		98.86%	否
HY-10524	GSK1904529A		98.89%	否
HY-13203	NVP-TAE 226		99.77%	否
HY-P5438	Srctide	Substrate	99.93%	否
HY-100349	SU4312	Inhibitor	99.76%	否
HY-18785	Indirubin Derivative E804	Inhibitor	98.54%	否
HY-145110	IGF-1R inhibitor-2	Inhibitor	98.36%	否
HY-135680	I-OMe-Tyrphostin AG 538	Inhibitor	98.03%	否
HY-B0794	AZ7550	Inhibitor	/	否
HY-125102	AZ12253801	Inhibitor	/	否
HY-50866B	NVP-AEW541 dihydrochloride		/	否
HY-108230	ALK-IN-12	Inhibitor	/	否
HY-118046	GSK2163632A	Inhibitor	/	否
HY-15494S1	Picropodophyllin-d6		/	否
HY-156914	IGF-1R/SRC-IN-1	Inhibitor	99.86%	否
HY-162506	IGF-1R inhibitor-3	Inhibitor	/	否
HY-167854	KW-2450 free base		/	否
HY-402309	IGF-1R modulator 1	Modulator	/	否
HY-B0794S	AZ7550-d5	Inhibitor	/	否
HY-RS06615	IGF1R Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06616	Igf1r Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06617	Igf1r Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-100349A	cis-SU4312	Inhibitor	/	否
HY-14357	BMS 695735	Inhibitor	/	否
HY-168616	CL-A3-7	Inhibitor	/	否
HY-21291	SU-4313	Modulator	/	否
HY-N6611	Chimaphilin	Inhibitor	/	否
HY-P3226	JB-1	Antagonist	/	否

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P990084	Veligrotug	Inhibitor	99.25%	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Igf1r	NCBI	NCBI:3480
Macaca fascicularis	Igf1r	NCBI	NCBI:102130142
Mus musculus	Igf1r	NCBI	NCBI:16001

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