Il10 - interleukin 10 Gene

中文名称：白细胞介素 10

种属: Mus musculus

同用名: CSIF; If2a; Il-10

关于 Il10

功能概要

该基因编码一种抗炎细胞因子，属于 2 类细胞因子家族。编码的蛋白质由先天性和适应性免疫系统的细胞分泌，对于限制对多种病原体的免疫反应至关重要。它也被证明可以抑制自身免疫反应。这种蛋白质通过特定的白细胞介素 10 受体复合物介导其免疫抑制信号。该基因的异常功能与许多免疫疾病有关，包括移植物抗宿主病，以及对 HIV-1 感染和类风湿性关节炎的易感性增加。 [RefSeq 提供，2015 年 9 月]

This gene encodes an anti-inflammatory cytokine that is a member of the class-2 cytokine family. The encoded protein is secreted by cells of both the innate and adaptive immune systems and is crucial for limiting the immune response to a broad range of pathogens. It also has been shown to suppress autoimmune responses. This protein mediates it's immunosuppressive signal through a specific interleukin 10 receptor complex. Aberrant functioning of this gene is associated with numerous immune disorders including graft-versus-host disease, and increased susceptibility to HIV-1 Infection and rheumatoid arthritis. [provided by RefSeq, Sep 2015]