1. Gene
  2. Il10 - interleukin 10 Gene

Il10 - interleukin 10 Gene

中文名称:白细胞介素 10

种属: Rattus norvegicus

同用名: If2a; IL10X

基因 ID: 25325 | 基因类型: protein coding

关于 Il10

Primary_assembly 13: 42,472,839-42,477,313 forward strand.mRatBN7.2:CM026986.1

This gene has 1 transcript (splice variant), 193 orthologues, 3 paralogues and is associated with 243 phenotypes. Biased expression in Spleen (RPKM 3.6), Thymus (RPKM 1.9) and 7 other tissues.

功能概要

该基因编码的蛋白可启动白细胞介素 10 受体结合活性。参与多个过程,包括细胞对雌二醇刺激的反应;肝再生;一氧化氮生物合成过程的负调控。位于细胞外空间。用于研究多种疾病,包括肺部疾病(多种);围产期坏死性小肠结肠炎;坐骨神经病;中毒性脑病;和短暂性脑缺血。多种疾病的生物标志物,包括动脉疾病(多种);褥疮;肺部疾病(多发);阻塞性睡眠呼吸暂停;和产后抑郁症。该基因的人类直系同源物与多种疾病有关,包括动脉疾病(多种);自身免疫性疾病(多种);眼病(多发);胃肠系统癌症(多发性);和血液系统癌症(多种)。与人 IL10(白细胞介素 10)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables interleukin-10 receptor binding activity. Involved in several processes, including cellular response to estradiol stimulus; liver regeneration; and negative regulation of nitric oxide biosynthetic process. Located in extracellular space. Used to study several diseases, including lung disease (multiple); perinatal necrotizing enterocolitis; sciatic neuropathy; toxic encephalopathy; and transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); decubitus ulcer; lung disease (multiple); obstructive sleep apnea; and postpartum depression. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system Cancer (multiple); and hematologic Cancer (multiple). Orthologous to human IL10 (interleukin 10). [provided by Alliance of Genome Resources, Apr 2022]

Il10 基因产物(1)

mRNA Protein Name
NM_012854.2 NP_036986.2 interleukin-10 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables interleukin-10 receptor binding IDA
IDA: 通过直接分析推断
12405978 RGD
enables interleukin-10 receptor binding IMP
IMP: 通过突变表型推断
19428551 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to estradiol stimulus IEP
IEP: 通过表达模式推断
20735828 RGD
involved in immune response IMP
IMP: 通过突变表型推断
8484757 RGD
involved in liver regeneration IEP
IEP: 通过表达模式推断
11813605 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
19395591 RGD
involved in negative regulation of cytokine production IMP
IMP: 通过突变表型推断
8484757 RGD
involved in negative regulation of neuron apoptotic process IDA
IDA: 通过直接分析推断
28753520 RGD
involved in negative regulation of nitric oxide biosynthetic process IDA
IDA: 通过直接分析推断
17017555 RGD
involved in negative regulation of tumor necrosis factor production IDA
IDA: 通过直接分析推断
17017555 RGD
involved in positive regulation of macrophage activation IDA
IDA: 通过直接分析推断
25837415 RGD
involved in regulation of synapse organization IDA
IDA: 通过直接分析推断
24278397 RGD
involved in response to activity IEP
IEP: 通过表达模式推断
19424714 RGD
involved in response to carbon monoxide IEP
IEP: 通过表达模式推断
20622590 RGD
involved in response to glucocorticoid IEP
IEP: 通过表达模式推断
16827395 RGD
involved in response to inactivity IEP
IEP: 通过表达模式推断
17033197 RGD
involved in response to insulin IEP
IEP: 通过表达模式推断
18791499 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
18791499 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
19419978 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
18787467 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Il10 蛋白结构

IL10

IL10: cl02501 (13 - 125)

  • 0
  • 100
  • 200
  • 217 a.a.
蛋白主名 其他名称

interleukin-10

CSIF

IL-10

cytokine synthesis inhibitory factor

interferon 2a

重组 Il10 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7098 IL-10 Protein, Rat P29456 (S19-N178) ≥95%
HY-P7098A IL-10 Protein, Rat (CHO) P29456 (S19-N178) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Il10 NCBI NCBI:3586
Canis familiaris Il10 NCBI NCBI:403628
Macaca fascicularis Il10 NCBI NCBI:102133450
Mus musculus Il10 NCBI NCBI:16153
Susscrofa domestica Il10 NCBI