2. Gene
  3. Il12a - interleukin 12a Gene

Il12a - interleukin 12a Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：白细胞介素 12 a

种属: Mus musculus

同用名: p35; Ll12a; Il-12a; IL-12p35

基因 ID: 16159 | 基因类型: protein coding

关于 Il12a

Chromosome 3: 68,597,977-68,605,880 forward strand.GRCm39:CM000996.3

This gene has 6 transcripts (splice variants), 234 orthologues and is associated with 14 phenotypes.

功能概要

该基因编码的蛋白可启动白细胞介素 12 β 亚基结合活性。有助于细胞因子活性。作用于多个过程的上游或内部，包括 T-helper 1 细胞激活；对原生动物的防御反应；和 T 细胞活化的正调节。位于细胞表面；细胞质；和细胞外空间。白细胞介素 12 复合体的一部分。在大脑中表达；肺;小肠;睾丸;和胸腺。该基因与丙型肝炎有关的人类直系同源物；肝细胞癌；和原发性胆汁性胆管炎。与人 IL12A（白细胞介素 12A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables interleukin-12 beta subunit binding activity. Contributes to cytokine activity. Acts upstream of or within several processes, including T-helper 1 cell activation; defense response to protozoan; and positive regulation of T cell activation. Located in cell surface; cytoplasm; and extracellular space. Part of interleukin-12 complex. Is expressed in brain; lung; small intestine; testis; and thymus. Human ortholog(s) of this gene implicated in hepatitis C; hepatocellular carcinoma; and primary biliary cholangitis. Orthologous to human IL12A (interleukin 12A). [provided by Alliance of Genome Resources, Apr 2022]

Il12a 基因产物(6)

mRNA Protein Name
NM_001159424.3 NP_001152896.2 interleukin-12 subunit alpha isoform 2 precursor
NM_001410419.1 NP_001397348.1 interleukin-12 subunit alpha isoform 5
NM_001410417.1 NP_001397346.1 interleukin-12 subunit alpha isoform 3 precursor
NM_001410418.1 NP_001397347.1 interleukin-12 subunit alpha isoform 4
NM_001410420.1 NP_001397349.1 interleukin-12 subunit alpha isoform 5
NM_008351.4 NP_032377.1 interleukin-12 subunit alpha isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to cytokine activity IDA
IDA: 通过直接分析推断
11057672 MGI
enables interleukin-12 beta subunit binding IPI
IPI: 通过物理相互作用推断
15220916 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
18033300 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of T cell proliferation IDA
IDA: 通过直接分析推断
11057672 MGI
acts upstream of or within T-helper 1 cell activation IDA
IDA: 通过直接分析推断
22851706 MGI
acts upstream of or within T-helper 1 cell cytokine production IGI
IGI: 通过遗传相互作用推断
15843532 MGI
acts upstream of or within cell population proliferation IDA
IDA: 通过直接分析推断
15843532 MGI
acts upstream of or within cell population proliferation IGI
IGI: 通过遗传相互作用推断
15843532 MGI
acts upstream of or within cellular response to lipopolysaccharide IDA
IDA: 通过直接分析推断
19047410 MGI
acts upstream of or within defense response to protozoan IDA
IDA: 通过直接分析推断
19047410 MGI
acts upstream of or within defense response to protozoan IGI
IGI: 通过遗传相互作用推断
9348310 MGI
acts upstream of or within positive regulation of T cell differentiation IGI
IGI: 通过遗传相互作用推断
22968459 MGI
acts upstream of or within positive regulation of T cell proliferation IDA
IDA: 通过直接分析推断
11057672 MGI
acts upstream of or within positive regulation of type II interferon production IDA
IDA: 通过直接分析推断
21444916 MGI
acts upstream of or within positive regulation of type II interferon production IGI
IGI: 通过遗传相互作用推断
9348310 MGI
acts upstream of type II interferon production IDA
IDA: 通过直接分析推断
21444916 MGI
acts upstream of type II interferon production IGI
IGI: 通过遗传相互作用推断
9348310 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
20818394 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
11737071 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
7690439 MGI
part of interleukin-12 complex IDA
IDA: 通过直接分析推断
15220916 MGI
part of interleukin-12 complex IGI
IGI: 通过遗传相互作用推断
7690439 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

interleukin-12 subunit alpha

CLMF p35

IL-12 p35 subunit

IL-12 subunit p35

cytotoxic lymphocyte maturation factor 35 kDa subunit

interleukin 12a p35 subunit

interleukin-12 p35 subunit

重组 Il12a 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7208 IL-12 Protein, Mouse (CHO) P43431 (R23-A215) & P43432 (M23-S335) ≥95%
HY-P70666 IL-12 Protein, Mouse (HEK293) P43431 (R23-A215) & P43432 (M23-S335) ≥95%
HY-P73158 IL-12 Protein, Mouse (HEK293, His-Fc) P43431 (R23-A215) & P43432 (M23-S335) ≥95%
HY-P73159 IL-12 Protein, Mouse (HEK293, His) P43431 (R23-A215) & P43432 (M23-S335) ≥95%
HY-P73157 IL-12 Protein, Mouse (HEK293, Fc) P43431 (R23-A215) & P43432 (M23-S335) ≥95%
HY-P700190AF Animal-Free IL-12 alpha Protein, Mouse (His) P43431 (R23-A215) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06677 IL12A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06678 Il12a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06679 Il12a Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Il12a NCBI NCBI:3592
Macaca fascicularis Il12a NCBI NCBI:102115316
Macaca mulatta Il12a NCBI NCBI:703205
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