2. Gene
  3. IL12A - interleukin 12A Gene

IL12A - interleukin 12A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：白细胞介素 12A

种属: Homo sapiens

同用名: P35; CLMF; NFSK; NKSF1; IL-12A

基因 ID: 3592 | 基因类型: protein coding

关于 IL12A

Cytogenetic location: 3q25.33 Genomic coordinates (GRCh38): 3:159,988,835-159,996,019 (from NCBI)

This gene has 7 transcripts (splice variants), 233 orthologues and is associated with 2 phenotypes. Broad expression in esophagus (RPKM 2.2), lung (RPKM 1.4) and 19 other tissues.

功能概要

该基因编码作用于 T 细胞和自然杀伤细胞的细胞因子亚基，具有广泛的生物活性。细胞因子是由该基因编码的 35-kD 亚基和作为细胞因子受体家族成员的 40-kD 亚基组成的二硫键连接的异二聚体。这种细胞因子是干扰素 (IFN) -γ 的非 T 细胞依赖性诱导所必需的，并且对于 Th1 和 Th2 细胞的分化很重要。淋巴细胞对这种细胞因子的反应是由转录蛋白 STAT4 的激活剂介导的。一氧化氮合酶 2A (NOS2A/NOS2) 被发现是该细胞因子在先天免疫中的信号传导过程所必需的。[RefSeq 提供，2008 年 7 月]

This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]

IL12A 基因产物(4)

mRNA Protein Name
NM_001354582.2 NP_001341511.1 interleukin-12 subunit alpha isoform 2
NM_001397992.1 NP_001384921.1 interleukin-12 subunit alpha isoform 4 precursor
NM_001354583.2 NP_001341512.1 interleukin-12 subunit alpha isoform 3
NM_000882.4 NP_000873.2 interleukin-12 subunit alpha isoform 1 precursor

IL12A 蛋白结构

IL12

IL12: Interleukin-12 alpha subunit (35 - 253)

  • 0
  • 100
  • 200
  • 253 a.a.
蛋白主名 其他名称

interleukin-12 subunit alpha

CLMF p35

IL-12, subunit p35

IL35 subunit

NF cell stimulatory factor chain 1

NK cell stimulatory factor chain 1

cytotoxic lymphocyte maturation factor 1, p35

cytotoxic lymphocyte maturation factor 35 kDa subunit

interleukin 12, p35

interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)

interleukin-12 alpha chain

重组 IL12A 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7032 IL-12 Protein, Human (HEK293) P29459 (R23-S219) & P29460 (I23-S328) ≥95%
HY-P70338 IL-35 Protein, Human (HEK293, Fc) P29459 (R23-S219)&Q14213 (R21-K229) ≥95%
HY-P7032G GMP IL-12 Protein, Human (HEK293) P29459 (R23-S219) & P29460 (I23-S328) ≥95%
HY-P73156 GMP IL-12 Protein, Human (HEK293, His) P29459 (R23-S219) & P29460 (I23-S328) ≥95%
HY-P73880 IL-35 Protein, Human (HEK293, Flag-His) P29459 (R23-S219)&Q14213 (R21-K229) ≥95%
HY-P73882 IL-35 Protein, Human (HEK293, His-hFc-Myc) P29459 (R23-S219)&Q14213 (R21-K229) ≥95%
HY-P73898 IL-12 Protein, Human (HEK293, His) P29459 (R23-S219) & P29460 (I23-S328) ≥95%
HY-P77511 IL-12 Protein, Human (Biotinylated, HEK293, His) P29459 (R23-S219) & P29460 (I23-S328) ≥95%
HY-P77702 IL-12 Protein, Human (Biotinylated, HEK293, His-Avi) P29459 (R23-S219) & P29460 (I23-S328) ≥95%
HY-P700099AF Animal-Free IL-12 alpha Protein, Human (His) P29459 (R23-S219) ≥95%

关联疾病

疾病名称 别名
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Behcet Syndrome

Behcet Disease

Behcet'S Syndrome

Behcet'S Disease

Behçet Disease

Bd

Adamantiades-Behcet Disease

Triple Symptom Complex

Behet'S Syndrome

Bd Syndrome

Behçet Syndrome

Behçet'S Disease

Behçet'S Syndrome

Behcet Triple Symptom Complex

Malignant Aphthosis

Old Silk Route Disease

Adamantiades-Behçet Disease
Primary Biliary Cholangitis

Primary Biliary Cirrhosis

Biliary Liver Cirrhosis

Chronic Nonsuppurative Destructive Cholangitis

Familial Primary Biliary Cirrhosis

Pbc

Hanot Syndrome

Cholestatic Cirrhosis

Biliary Cirrhosis Primary

Liver Cirrhosis, Biliary

Hanot'S Cirrhosis

Biliary Cirrhosis

Pericholangiolic Biliary Cirrhosis

Tannhauser-Magendantz Syndrome

Hanot-Rossle Syndrome

Hypertrophic Cirrhosis

Todd Cirrhosis

Hanot Cirrhosis

Charcot Cirrhosis

Mahon-Tannhauser Syndrome

Toxic Cirrhosis

Hypertrophic Biliary Cirrhosis

Monolobular Cirrhosis

Unilobar Cirrhosis

Xanthomatous Biliary Cirrhosis
Properdin Deficiency, X-Linked

Properdin Deficiency

PFD

CFPD

Properdin P Factor Deficiency

Complement Factor Properdin Deficiency

X-Linked Properdin Deficiency

Properdin Deficiency, Type I

Properdin Deficiency, Type 1

Properdin Deficiency Disease
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06677 IL12A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06678 Il12a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06679 Il12a Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus IL12A RGD RGD:620562
Mus musculus IL12A MGD MGI:96539
Canis familiaris IL12A VGNC VGNC:41932
Bos taurus IL12A VGNC VGNC:30110
Felis catus IL12A VGNC VGNC:102761
Macaca mulatta IL12A VGNC VGNC:84168
Macaca fascicularis IL12A NCBI NCBI:102115316
Others IL12A NCBI
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