IL12A - interleukin 12A Gene

中文名称：白细胞介素 12A

种属: Homo sapiens

同用名: P35; CLMF; NFSK; NKSF1; IL-12A

基因 ID: 3592 | 基因类型: protein coding

关于 IL12A

Cytogenetic location: 3q25.33 Genomic coordinates (GRCh38): 3:159,988,835-159,996,019 (from NCBI)

This gene has 7 transcripts (splice variants), 233 orthologues and is associated with 2 phenotypes. Broad expression in esophagus (RPKM 2.2), lung (RPKM 1.4) and 19 other tissues.

功能概要

该基因编码作用于 T 细胞和自然杀伤细胞的细胞因子亚基，具有广泛的生物活性。细胞因子是由该基因编码的 35-kD 亚基和作为细胞因子受体家族成员的 40-kD 亚基组成的二硫键连接的异二聚体。这种细胞因子是干扰素 (IFN) -γ 的非 T 细胞依赖性诱导所必需的，并且对于 Th1 和 Th2 细胞的分化很重要。淋巴细胞对这种细胞因子的反应是由转录蛋白 STAT4 的激活剂介导的。一氧化氮合酶 2A (NOS2A/NOS2) 被发现是该细胞因子在先天免疫中的信号传导过程所必需的。[RefSeq 提供，2008 年 7 月]

This gene encodes a subunit of a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. The cytokine is a disulfide-linked heterodimer composed of the 35-kD subunit encoded by this gene, and a 40-kD subunit that is a member of the cytokine receptor family. This cytokine is required for the T-cell-independent induction of interferon (IFN)-gamma, and is important for the differentiation of both Th1 and Th2 cells. The responses of lymphocytes to this cytokine are mediated by the activator of transcription protein STAT4. Nitric oxide synthase 2A (NOS2A/NOS2) is found to be required for the signaling process of this cytokine in innate immunity. [provided by RefSeq, Jul 2008]

IL12A 基因产物(4)

mRNA	Protein	Name
NM_001354582.2	NP_001341511.1	interleukin-12 subunit alpha isoform 2
NM_001397992.1	NP_001384921.1	interleukin-12 subunit alpha isoform 4 precursor
NM_001354583.2	NP_001341512.1	interleukin-12 subunit alpha isoform 3
NM_000882.4	NP_000873.2	interleukin-12 subunit alpha isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
contributes to cytokine activity	IDA IDA: 通过直接分析推断	1674604	GOA
enables cytokine activity	IDA IDA: 通过直接分析推断	7584494	GOA
contributes to growth factor activity	IDA IDA: 通过直接分析推断	1674604	GOA
enables interleukin-12 beta subunit binding	IPI IPI: 通过物理相互作用推断	11023671	GOA
enables interleukin-27 binding	IPI IPI: 通过物理相互作用推断	9342359	GOA
enables protein binding	IDA IDA: 通过直接分析推断	10899108	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	7527811	GOA
enables protein heterodimerization activity	IPI IPI: 通过物理相互作用推断	1674604	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell migration	IDA IDA: 通过直接分析推断	7903063	GOA
involved in cellular response to virus	IMP IMP: 通过突变表型推断	25754930	GOA
involved in defense response to Gram-positive bacterium	IEP IEP: 通过表达模式推断	1357073	GOA
involved in extrinsic apoptotic signaling pathway	IDA IDA: 通过直接分析推断	16942485	GOA
involved in interleukin-12-mediated signaling pathway	IDA IDA: 通过直接分析推断	7584494	GOA
acts upstream of negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis	IGI IGI: 通过遗传相互作用推断	30106099	GOA
involved in negative regulation of interleukin-17 production	IDA IDA: 通过直接分析推断	16482511	GOA
acts upstream of or within negative regulation of protein secretion	IGI IGI: 通过遗传相互作用推断	30106099	GOA
involved in negative regulation of smooth muscle cell proliferation	IDA IDA: 通过直接分析推断	16942485	GOA
acts upstream of negative regulation of vascular endothelial growth factor signaling pathway	IGI IGI: 通过遗传相互作用推断	30106099	GOA
involved in positive regulation of NK T cell activation	IDA IDA: 通过直接分析推断	19088061	GOA
involved in positive regulation of T cell mediated cytotoxicity	IDA IDA: 通过直接分析推断	1674604	GOA
involved in positive regulation of cell adhesion	IDA IDA: 通过直接分析推断	7903063	GOA
involved in positive regulation of dendritic cell chemotaxis	IMP IMP: 通过突变表型推断	25754930	GOA
involved in positive regulation of lymphocyte proliferation	IDA IDA: 通过直接分析推断	1674604	GOA
involved in positive regulation of mononuclear cell proliferation	IMP IMP: 通过突变表型推断	11023671	GOA
involved in positive regulation of natural killer cell activation	IDA IDA: 通过直接分析推断	1674604	GOA
involved in positive regulation of natural killer cell mediated cytotoxicity	IDA IDA: 通过直接分析推断	2204066	GOA
involved in positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IDA IDA: 通过直接分析推断	7903063	GOA
involved in positive regulation of smooth muscle cell apoptotic process	IDA IDA: 通过直接分析推断	16942485	GOA
involved in positive regulation of type II interferon production	IDA IDA: 通过直接分析推断	1674604	GOA
involved in positive regulation of tyrosine phosphorylation of STAT protein	IDA IDA: 通过直接分析推断	12372421	GOA
involved in response to UV-B	IDA IDA: 通过直接分析推断	8992506	GOA
involved in response to lipopolysaccharide	IDA IDA: 通过直接分析推断	7605994	GOA
involved in response to virus	IEP IEP: 通过表达模式推断	16548883	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in extracellular space	IDA IDA: 通过直接分析推断	10899108	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	16456693	GOA
part of interleukin-12 complex	IDA IDA: 通过直接分析推断	2204066	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IL12A 蛋白结构

IL12

0
100
200
253 a.a.

蛋白主名

其他名称

interleukin-12 subunit alpha

CLMF p35	IL-12, subunit p35
IL35 subunit	NF cell stimulatory factor chain 1
NK cell stimulatory factor chain 1	cytotoxic lymphocyte maturation factor 1, p35
cytotoxic lymphocyte maturation factor 35 kDa subunit	interleukin 12, p35
interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)	interleukin-12 alpha chain

重组 IL12A 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7032	IL-12 Protein, Human (HEK293)	P29459 (R23-S219) & P29460 (I23-S328)	≥95%
HY-P70338	IL-35 Protein, Human (HEK293, Fc)	P29459 (R23-S219)&Q14213 (R21-K229)	≥95%
HY-P7032G	GMP IL-12 Protein, Human (HEK293)	P29459 (R23-S219) & P29460 (I23-S328)	≥95%
HY-P73156	GMP IL-12 Protein, Human (HEK293, His)	P29459 (R23-S219) & P29460 (I23-S328)	≥95%
HY-P73880	IL-35 Protein, Human (HEK293, Flag-His)	P29459 (R23-S219)&Q14213 (R21-K229)	≥95%
HY-P73882	IL-35 Protein, Human (HEK293, His, hFc-Flag)	P29459 (R23-S219)&Q14213 (R21-K229)	≥95%
HY-P73898	IL-12 Protein, Human (HEK293, His)	P29459 (R23-S219) & P29460 (I23-S328)	≥95%
HY-P77511	IL-12 Protein, Human (Biotinylated, HEK293, His)	P29459 (R23-S219) & P29460 (I23-S328)	≥95%
HY-P77702	IL-12 Protein, Human (Biotinylated, HEK293, His-Avi)	P29459 (R23-S219) & P29460 (I23-S328)	≥95%
HY-P700099AF	Animal-Free IL-12 alpha Protein, Human (His)	P29459 (R23-S219)	≥95%

关联疾病

疾病名称

别名

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Behcet Syndrome

Behcet Disease	Behcet'S Syndrome
Behcet'S Disease	Behçet Disease
Bd	Adamantiades-Behcet Disease
Triple Symptom Complex	Behet'S Syndrome
Bd Syndrome	Behçet Syndrome
Behçet'S Disease	Behçet'S Syndrome
Behcet Triple Symptom Complex	Malignant Aphthosis
Old Silk Route Disease	Adamantiades-Behçet Disease

Primary Biliary Cholangitis

Primary Biliary Cirrhosis	Biliary Liver Cirrhosis
Chronic Nonsuppurative Destructive Cholangitis	Familial Primary Biliary Cirrhosis
Pbc	Hanot Syndrome
Cholestatic Cirrhosis	Biliary Cirrhosis Primary
Liver Cirrhosis, Biliary	Hanot'S Cirrhosis
Biliary Cirrhosis	Pericholangiolic Biliary Cirrhosis
Tannhauser-Magendantz Syndrome	Hanot-Rossle Syndrome
Hypertrophic Cirrhosis	Todd Cirrhosis
Hanot Cirrhosis	Charcot Cirrhosis
Mahon-Tannhauser Syndrome	Toxic Cirrhosis
Hypertrophic Biliary Cirrhosis	Monolobular Cirrhosis
Unilobar Cirrhosis	Xanthomatous Biliary Cirrhosis

Properdin Deficiency, X-Linked

Properdin Deficiency	PFD
CFPD	Properdin P Factor Deficiency
Complement Factor Properdin Deficiency	X-Linked Properdin Deficiency
Properdin Deficiency, Type I	Properdin Deficiency, Type 1
Properdin Deficiency Disease

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS06677	IL12A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06678	Il12a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06679	Il12a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	IL12A	RGD	RGD:620562
Mus musculus	IL12A	MGD	MGI:96539
Canis familiaris	IL12A	VGNC	VGNC:41932
Bos taurus	IL12A	VGNC	VGNC:30110
Felis catus	IL12A	VGNC	VGNC:102761
Macaca mulatta	IL12A	VGNC	VGNC:84168
Macaca fascicularis	IL12A	NCBI	NCBI:102115316
Others	IL12A	NCBI

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站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

IL12A - interleukin 12A Gene

关于 IL12A

功能概要

IL12A 基因产物(4)

IL12A 蛋白结构

重组 IL12A 蛋白

关联疾病

直系同源

热门区域

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IL12A - interleukin 12A Gene

关于 IL12A

功能概要

IL12A 基因产物(4)

IL12A 蛋白结构

重组 IL12A 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z