2. Gene
  3. TENT2 - terminal nucleotidyltransferase 2 Gene

TENT2 - terminal nucleotidyltransferase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：末端核苷酸转移酶 2

种属: Homo sapiens

同用名: APD4; GLD2; TUT2; PAPD4

基因 ID: 167153 | 基因类型: protein coding

关于 TENT2

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:79,612,441-79,688,246 (from NCBI)

This gene has 17 transcripts (splice variants), 202 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 14.6), lymph node (RPKM 12.6) and 25 other tissues.

功能概要

启用 5'-3' RNA 聚合酶活性和多核苷酸腺苷酸转移酶活性。参与 RNA 代谢过程和 RNA 分解代谢过程的负调控。预测位于核内。预计是核 RNA 指导的 RNA 聚合酶复合物的一部分。预计在胞质溶胶中有活性。 [由基因组资源联盟提供，2022 年 4 月]

Enables 5'-3' RNA polymerase activity and polynucleotide adenylyltransferase activity. Involved in RNA metabolic process and negative regulation of RNA catabolic process. Predicted to be located in nucleus. Predicted to be part of nuclear RNA-directed RNA polymerase complex. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

TENT2 基因产物(56)

mRNA Protein Name
NM_001114393.3 NP_001107865.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001114394.3 NP_001107866.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001297744.3 NP_001284673.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001297745.3 NP_001284674.1 poly(A) RNA polymerase GLD2 isoform 3
NM_001349548.2 NP_001336477.1 poly(A) RNA polymerase GLD2 isoform 4
NM_001349549.2 NP_001336478.1 poly(A) RNA polymerase GLD2 isoform 5
NM_001349550.2 NP_001336479.1 poly(A) RNA polymerase GLD2 isoform 5
NM_001349551.2 NP_001336480.1 poly(A) RNA polymerase GLD2 isoform 6
NM_001349552.2 NP_001336481.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001349553.2 NP_001336482.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001349554.2 NP_001336483.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388093.1 NP_001375022.1 poly(A) RNA polymerase GLD2 isoform 5
NM_001388094.1 NP_001375023.1 poly(A) RNA polymerase GLD2 isoform 5
NM_001388095.1 NP_001375024.1 poly(A) RNA polymerase GLD2 isoform 6
NM_001388096.1 NP_001375025.1 poly(A) RNA polymerase GLD2 isoform 6
NM_001388097.1 NP_001375026.1 poly(A) RNA polymerase GLD2 isoform 6
NM_001388098.1 NP_001375027.1 poly(A) RNA polymerase GLD2 isoform 7
NM_001388099.1 NP_001375028.1 poly(A) RNA polymerase GLD2 isoform 8
NM_001388100.1 NP_001375029.1 poly(A) RNA polymerase GLD2 isoform 8
NM_001388101.1 NP_001375030.1 poly(A) RNA polymerase GLD2 isoform 9
NM_001388102.1 NP_001375031.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001388103.1 NP_001375032.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001388105.1 NP_001375034.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001388106.1 NP_001375035.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001388107.1 NP_001375036.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001388108.1 NP_001375037.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001388109.1 NP_001375038.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001388110.1 NP_001375039.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001388111.1 NP_001375040.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001388112.1 NP_001375041.1 poly(A) RNA polymerase GLD2 isoform 1
NM_001388113.1 NP_001375042.1 poly(A) RNA polymerase GLD2 isoform 16
NM_001388114.1 NP_001375043.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388115.1 NP_001375044.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388116.1 NP_001375045.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388117.1 NP_001375046.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388118.1 NP_001375047.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388119.1 NP_001375048.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388120.1 NP_001375049.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388121.1 NP_001375050.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388122.1 NP_001375051.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388123.1 NP_001375052.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388124.1 NP_001375053.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388125.1 NP_001375054.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388126.1 NP_001375055.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388127.1 NP_001375056.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388128.1 NP_001375057.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388129.1 NP_001375058.1 poly(A) RNA polymerase GLD2 isoform 2
NM_001388130.1 NP_001375059.1 poly(A) RNA polymerase GLD2 isoform 10
NM_001388131.1 NP_001375060.1 poly(A) RNA polymerase GLD2 isoform 11
NM_001388132.1 NP_001375061.1 poly(A) RNA polymerase GLD2 isoform 12
NM_001388133.1 NP_001375062.1 poly(A) RNA polymerase GLD2 isoform 3
NM_001388134.1 NP_001375063.1 poly(A) RNA polymerase GLD2 isoform 13
NM_001388135.1 NP_001375064.1 poly(A) RNA polymerase GLD2 isoform 13
NM_001388136.1 NP_001375065.1 poly(A) RNA polymerase GLD2 isoform 14
NM_001388137.1 NP_001375066.1 poly(A) RNA polymerase GLD2 isoform 15
NM_173797.5 NP_776158.2 poly(A) RNA polymerase GLD2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables poly(A) RNA polymerase activity IDA
IDA: 通过直接分析推断
15070731 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in histone mRNA catabolic process IMP
IMP: 通过突变表型推断
18172165 GOA
involved in mRNA 3'-end processing IDA
IDA: 通过直接分析推断
15070731 GOA
involved in negative regulation of miRNA catabolic process IDA
IDA: 通过直接分析推断
23200856 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TENT2 蛋白结构

PAP_assoc

PAP_assoc: Cid1 family poly A polymerase (386 - 440)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 484 a.a.
蛋白主名 其他名称

poly(A) RNA polymerase GLD2

PAP associated domain containing 4

TENT2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TENT2 Q6PIY7 CADPS Homo sapiens A2RRN7
Y2H Prey Pooling
32296183
Intra TENT2 Q6PIY7 CADPS Homo sapiens A2RRN7
Y2H Array
32296183
Intra TENT2 Q6PIY7 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra TENT2 Q6PIY7 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra TENT2 Q6PIY7 CALCOCO2 Homo sapiens Q13137
Validated Y2H
25416956
Intra TENT2 Q6PIY7 RBPMS Homo sapiens Q93062
Y2H Array
25416956
Intra TENT2 Q6PIY7 RBPMS Homo sapiens Q93062
Y2H Prey Pooling
25416956
Intra TENT2 Q6PIY7 DTX2 Homo sapiens Q86UW9
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Trichothiodystrophy 1, Photosensitive

TTD1

Tay Syndrome

Trichothiodystrophy With Congenital Ichthyosis

Photosensitive Trichothiodystrophy

Ibids Syndrome

Ttdp

Ichthyosiform Erythroderma With Hair Abnormality And Mental And Growth Retardation

Ichthyosis, Congenital, With Trichothiodystrophy

Pibids Syndrome

Photosensitive Trichothiodystrophy 1

Trichothiodystrophy, Photosensitive

Sulfur-Deficient Brittle Hair Syndrome

Ttd-P

Ichthyosis With Brittle Hair, Intellectual Impairment, Decreased Fertility And Short Stature

Trichothiodystrophy Photosensitive

Trichothiodystrophy, Type 1

Tricho-Thiodystrophy Disorder

Trichothiodystrophy Syndromes

Amish Brittle Hair Brain Syndrome
Trichothiodystrophy 6, Nonphotosensitive

TTD6

Nonphotosensitive Trichothiodystrophy 6

Trichothiodystrophy 6, Non-Photosensitive
Nonphotosensitive Trichothiodystrophy

Trichothiodystrophy Nonphotosensitive

Amish Brittle Hair Brain Syndrome
Perlman Syndrome

Nephroblastomatosis, Fetal Ascites, Macrosomia And Wilms Tumor

PRLMNS

Renal Hamartomas, Nephroblastomatosis, And Fetal Gigantism

Nephroblastomatosis Fetal Ascites Macrosomia And Wilms Tumor

Nephroblastomatosis, Fetal Ascites, Macrosomia, And Wilms Tumor

Nephroblastomatosis - Fetal Ascites - Macrosomia - Wilms Tumor

Renal Hamartomas, Nephroblastomatosis And Fetal Gigantism

Nephroblastomatosis-Fetal Ascites-Macrosomia-Wilms Tumor Syndrome

Renal Hamartomas Nephroblastomatosis And Fetal Gigantism

Nephroblastoma

Fetal Macrosomia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14366 TENT2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TENT2 VGNC VGNC:53194
Macaca mulatta TENT2 VGNC VGNC:79637
Mus musculus TENT2 MGD MGI:2140950
Felis catus TENT2 VGNC VGNC:66073
Rattus norvegicus TENT2 RGD RGD:1306438
Bos taurus TENT2 VGNC VGNC:54564
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