2. Gene
  3. Tlr7 - toll-like receptor 7 Gene

Tlr7 - toll-like receptor 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：Toll 样受体 7

种属: Mus musculus

基因 ID: 170743 | 基因类型: protein coding

关于 Tlr7

Chromosome X: 166,087,925-166,113,554 reverse strand.GRCm39:CM001013.3

This gene has 6 transcripts (splice variants), 197 orthologues, 23 paralogues and is associated with 14 phenotypes. Low expression observed in reference dataset.

功能概要

该基因编码的蛋白可启动 siRNA 结合活性和单链 RNA 结合活性。参与多个过程，包括大分子代谢过程的正调控；对病毒的反应；和 toll 样受体 7 信号通路。在白细胞介素 6 的产生和蛋白质磷酸化的正调控的上游或内部发挥作用。位于细胞质囊泡中；内质网；和溶酶体。在脑和肝脏中表达。用于研究系统性红斑狼疮。该基因的人类直系同源物与 COVID-19 和 X 连锁免疫缺陷 74 相关。与人类 TLR7（toll 样受体 7）直系同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables siRNA binding activity and single-stranded RNA binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; response to virus; and Toll-like Receptor 7 signaling pathway. Acts upstream of or within positive regulation of interleukin-6 production and regulation of protein phosphorylation. Located in cytoplasmic vesicle; endoplasmic reticulum; and lysosome. Is expressed in brain and liver. Used to study systemic lupus erythematosus. Human ortholog(s) of this gene implicated in COVID-19 and X-Linked immunodeficiency 74. Orthologous to human TLR7 (toll like receptor 7). [provided by Alliance of Genome Resources, Apr 2022]

Tlr7 基因产物(5)

mRNA Protein Name
NM_001290757.1 NP_001277686.1 toll-like receptor 7 isoform a precursor
NM_001290756.1 NP_001277685.1 toll-like receptor 7 isoform a precursor
NM_001290755.1 NP_001277684.1 toll-like receptor 7 isoform a precursor
NM_001290758.1 NP_001277687.1 toll-like receptor 7 isoform b
NM_133211.4 NP_573474.1 toll-like receptor 7 isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17452530 MGI
enables siRNA binding IMP
IMP: 通过突变表型推断
15723075 MGI
enables single-stranded RNA binding IMP
IMP: 通过突变表型推断
14976262 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in JNK cascade IMP
IMP: 通过突变表型推断
18802055 MGI
involved in MAPK cascade IMP
IMP: 通过突变表型推断
18802055 MGI
involved in cellular response to virus IMP
IMP: 通过突变表型推断
18802055 MGI
involved in defense response to virus IMP
IMP: 通过突变表型推断
14976261 MGI
acts upstream of interleukin-6 production IDA
IDA: 通过直接分析推断
18261938 MGI
acts upstream of macrophage cytokine production IDA
IDA: 通过直接分析推断
18261938 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
12032557 MGI
involved in positive regulation of interferon-alpha production IMP
IMP: 通过突变表型推断
14976261 MGI
acts upstream of or within positive regulation of interleukin-6 production IDA
IDA: 通过直接分析推断
18261938 MGI
acts upstream of or within positive regulation of macrophage cytokine production IDA
IDA: 通过直接分析推断
18261938 MGI
involved in positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
18802055 MGI
acts upstream of or within regulation of protein phosphorylation IGI
IGI: 通过遗传相互作用推断
24740015 MGI
involved in toll-like receptor 7 signaling pathway IMP
IMP: 通过突变表型推断
14976261 MGI
involved in toll-like receptor 8 signaling pathway IDA
IDA: 通过直接分析推断
12032557 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in early phagosome IDA
IDA: 通过直接分析推断
18305481 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
18305481 MGI
located in endosome IDA
IDA: 通过直接分析推断
18305481 MGI
located in lysosome IDA
IDA: 通过直接分析推断
18305481 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Tlr7 蛋白结构

PRK15370

PRK15370: cl33128 (31 - 242)

LRR_RI

LRR_RI: sd00033 (47 - 68)

LRR_RI

LRR_RI: sd00033 (69 - 89)

LRR_RI

LRR_RI: sd00033 (90 - 127)

LRR_RI

LRR_RI: sd00033 (128 - 151)

LRR_RI

LRR_RI: sd00033 (173 - 204)

PLN00113

PLN00113: cl33413 (173 - 785)

LRR_RI

LRR_RI: sd00033 (205 - 225)

LRR_RI

LRR_RI: sd00033 (226 - 249)

LRR_RI

LRR_RI: sd00033 (250 - 290)

LRR_RI

LRR_RI: sd00033 (291 - 314)

LRR_RI

LRR_RI: sd00033 (315 - 340)

LRR_RI

LRR_RI: sd00033 (341 - 397)

LRR_RI

LRR_RI: sd00033 (398 - 421)

LRR_RI

LRR_RI: sd00033 (496 - 518)

LRR_RI

LRR_RI: sd00033 (519 - 543)

LRR_RI

LRR_RI: sd00033 (544 - 567)

LRR_RI

LRR_RI: sd00033 (568 - 597)

LRR_RI

LRR_RI: sd00033 (598 - 620)

LRR_RI

LRR_RI: sd00033 (621 - 651)

LRR_RI

LRR_RI: sd00033 (652 - 676)

LRR_RI

LRR_RI: sd00033 (677 - 700)

LRR_RI

LRR_RI: sd00033 (701 - 724)

LRR_RI

LRR_RI: sd00033 (749 - 774)

PCC

PCC: cl28216 (753 - 837)

TIR

TIR: smart00255 (890 - 1035)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1050 a.a.
蛋白主名 其他名称

toll-like receptor 7

Toll like receptor 7

相关产品

Approval
生物活性分子 (6)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0180 Imiquimod Agonist 99.96% 是
HY-B1370 Hydroxychloroquine sulfate Inhibitor 99.99% 是
HY-B0180A Imiquimod hydrochloride Agonist 99.77% 是
HY-B0180B Imiquimod maleate Agonist 99.25% 是
HY-B1370A (S)-Hydroxychloroquine Inhibitor / 否
HY-B1370B (R)-Hydroxychloroquine Inhibitor / 否
Clinical Phase
生物活性分子 (10)
目录号 产品名 作用方式
纯度 Phase
HY-13740 Resiquimod Agonist 99.95% Phase 2
HY-134581 Enpatoran Inhibitor 99.77% Phase 2
HY-134581A Enpatoran hydrochloride Inhibitor 99.33% Phase 2
HY-118250 GSK2245035 Agonist 99.85% Phase 2
HY-13740G Resiquimod (GMP) Agonist / Phase 2
HY-100176 PF-4878691 Agonist 99.89% Phase 2
HY-111269 AZD8848 Agonist 99.14% Phase 2
HY-13655A Isatoribine Agonist / Phase 2
HY-109104 Telratolimod Agonist 98.98% Phase 1
HY-111786 LHC-165 Agonist ≥98.0% Phase 1
Pre-clinical Phase
生物活性分子 (65)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-N0201 Atractylenolide I Antagonist 99.94% 否
HY-124603 AT791 Inhibitor 98.77% 否
HY-128799 CL097 Agonist 99.89% 否
HY-103698A TLR7/8 agonist 1 dihydrochloride Agonist 99.70% 否
HY-139323 TLR7/8-IN-1 Inhibitor 99.92% 否
HY-103697A Gardiquimod diTFA Agonist ≥99.0% 否
HY-108472 Loxoribine Agonist 99.64% 是
HY-103697 Gardiquimod Agonist 99.91% 否
HY-103698 TLR7/8 agonist 1 Agonist 97.33% 否
HY-12756A E6446 dihydrochloride Antagonist 99.96% 否
HY-135905 CL264 Inhibitor 98.63% 否
HY-110120 DSR-6434 Agonist 99.55% 否
HY-130797 TLR7/8 agonist 3 Agonist 99.96% 否
HY-150736 ODN 20844 Inhibitor / 否
HY-117602 TLR7 agonist 3 Agonist 99.90% 否
HY-131945 CU-115 Antagonist 99.55% 否
HY-139017 TLR7/8 agonist 4 Agonist 99.04% 否
HY-115400 1V209 Agonist 99.67% 否
HY-160229 ssRNA40 sodium Activator 93.25% 否
HY-10018 Toll-like receptor modulator Modulator 99.36% 否
HY-12756 E6446 Antagonist ≥98.0% 否
HY-153071 TLR7 agonist 6 Agonist 98.08% 否
HY-13740S Resiquimod-d5 Agonist 99.84% 否
HY-111358 TLR7 agonist 1 Agonist 98.95% 否
HY-110207 SM-324405 Agonist 98.52% 否
HY-128799A CL097 hydrochloride Agonist 99.51% 否
HY-150158 TMX-201 ≥95.0% 否
HY-157793 SMU-L11 Agonist 99.64% 否
HY-111582 BBIQ Agonist 99.85% 否
HY-160227A ORN 06 sodium Activator 90.78% 否
HY-145960 MC-Val-Cit-PAB-Amide-TLR7 agonist 4 Agonist 99.39% 否
HY-145961 TLR7 agonist 4 Agonist 98.87% 否
HY-150744 ODN 24888 Inhibitor / 否
HY-156174 E104 Inhibitor / 否
HY-153543 TLR7/8 agonist 8 Agonist / 否
HY-159102 PVP-037.2 Agonist / 否
HY-158694A TLR7 agonist 20 hydrochloride Agonist 99.86% 否
HY-138139A AXC-715 hydrochloride Agonist 99.46% 否
HY-139575 Guretolimod Agonist / 否
HY-147215 UC-1V150 Agonist / 否
HY-141454 TLR8 agonist 2 Agonist / 否
HY-141454A TLR8 agonist 2 hydrochloride Agonist / 否
HY-139017A TLR7/8 agonist 4 TFA Agonist / 否
HY-153070 TLR7 agonist 5 Agonist / 否
HY-168157 TLR7 agonist 26 Agonist / 否
HY-152726 TLR7 agonist 9 Agonist / 否
HY-163398 TLR7-IN-1 Inhibitor / 否
HY-162115 TLR7 agonist 17 Agonist / 否
HY-163670 TLR7 agonist 21 Inhibitor / 否
HY-156175 TLR7 agonist 14 Agonist / 否
HY-160227 ORN 06 Activator / 否
HY-162845 TLR7/8 agonist 11 Agonist / 否
HY-158694 TLR7 agonist 20 Agonist / 否
HY-169057 BI1543673 Inhibitor / 否
HY-168159 TLR7 agonist 27 Agonist / 否
HY-153073 TLR7 agonist 8 Agonist / 否
HY-169017 MTT5 Agonist / 否
HY-153072 TLR7 agonist 7 Agonist / 否
HY-B1370R Hydroxychloroquine sulfate (Standard) Inhibitor / 否
HY-162725 TLR7 agonist 24 Agonist / 否
HY-121496 3M-011 Agonist / 否
HY-159914 AYK004-B1 Agonist / 否
HY-159919 UM-3006 Agonist / 否
HY-159916 AYK004 Agonist / 否
HY-111582G BBIQ (GMP) Agonist / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tlr7 NCBI NCBI:51284
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