Mmp13 - matrix metallopeptidase 13 Gene

中文名称：基质金属肽酶 13

种属: Rattus norvegicus

关于 Mmp13

功能概要

该基因编码的蛋白可启动多种功能，包括纤连蛋白结合活性；低密度脂蛋白颗粒受体结合活性；和金属离子结合活性。参与多个过程，包括动物器官发育；胚胎后肢形态发生；和动情周期。位于多种细胞成分中，包括高尔基体；细胞间小管；和溶酶体。用于研究脑缺血；退行性椎间盘疾病；和心肌梗塞。多种疾病的生物标志物，包括退行性椎间盘疾病；胃溃疡;肝硬化（多发性）；脑膜炎球菌性脑膜炎;和矽肺。该基因的人类直系同源物与无牙症有关；动脉疾病（多发性）；骨关节炎;卵巢癌；和脊柱骨骺发育不良，密苏里型。与人 MMP13（基质金属肽酶 13）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including fibronectin binding activity; low-density lipoprotein particle receptor binding activity; and metal ion binding activity. Involved in several processes, including animal organ development; embryonic hindlimb morphogenesis; and estrous cycle. Located in several cellular components, including Golgi apparatus; intercellular canaliculus; and lysosome. Used to study brain ischemia; degenerative disc disease; and myocardial infarction. Biomarker of several diseases, including degenerative disc disease; gastric ulcer; liver cirrhosis (multiple); meningococcal meningitis; and silicosis. Human ortholog(s) of this gene implicated in anodontia; artery disease (multiple); osteoarthritis; ovarian carcinoma; and spondyloepimetaphyseal dysplasia, Missouri type. Orthologous to human MMP13 (matrix metallopeptidase 13). [provided by Alliance of Genome Resources, Apr 2022]