1. Gene
  2. Epcam - epithelial cell adhesion molecule Gene

Epcam - epithelial cell adhesion molecule Gene

种属: Rattus norvegicus

同用名: Egp314; Tacstd1

基因 ID: 171577 | 基因类型: protein coding

关于 Epcam

功能概要

Enables cadherin binding activity involved in cell-cell adhesion. Involved in cell-cell adhesion via plasma-membrane adhesion molecules; negative regulation of apoptotic process; and positive regulation of cell motility. Located in bicellular tight junction; cell surface; and lateral plasma membrane. Is integral component of membrane. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in congenital diarrhea 5 with tufting enteropathy and hereditary nonpolyposis colorectal Cancer type 8. Orthologous to human EPCAM (epithelial cell adhesion molecule). [provided by Alliance of Genome Resources, Apr 2022]

Epcam 基因产物(1)

mRNA Protein Name
NM_138541.2 NP_612550.1 epithelial cell adhesion molecule precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cadherin binding involved in cell-cell adhesion IPI
IPI: 通过物理相互作用推断
19276185 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell-cell adhesion via plasma-membrane adhesion molecules IDA
IDA: 通过直接分析推断
19276185 RGD
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
19276185 RGD
involved in positive regulation of cell motility IDA
IDA: 通过直接分析推断
19276185 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in bicellular tight junction IDA
IDA: 通过直接分析推断
16054130 RGD
located in cell surface IDA
IDA: 通过直接分析推断
19276185 RGD
located in lateral plasma membrane IDA
IDA: 通过直接分析推断
16054130 RGD
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

epithelial cell adhesion molecule

ep-CAM

epithelial glycoprotein 314

tumor-associated calcium signal transducer 1

重组 Epcam 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74172 EpCAM/TROP1 Protein, Rat (HEK293, His) O55159 (Q24-T266) ≥95%
HY-P74173 EpCAM/TROP1 Protein, Rat (HEK293, Fc) O55159 (Q24-T266) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Epcam NCBI NCBI:4072
Mus musculus Epcam NCBI NCBI:17075
Macaca mulatta Epcam NCBI NCBI:677680