2. Gene
  3. Mapkapk2 - MAP kinase-activated protein kinase 2 Gene

Mapkapk2 - MAP kinase-activated protein kinase 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：MAP 激酶活化蛋白激酶 2

种属: Mus musculus

同用名: MK2; MK-2; Rps6kc1; MAPKAP-K2

基因 ID: 17164 | 基因类型: protein coding

关于 Mapkapk2

Chromosome 1: 130,981,437-131,025,563 reverse strand.GRCm39:CM000994.3

This gene has 2 transcripts (splice variants), 238 orthologues, 6 paralogues and is associated with 33 phenotypes. Ubiquitous expression in heart adult (RPKM 82.3), adrenal adult (RPKM 65.) and 28 other tissues.

功能概要

该基因编码的蛋白可启动蛋白质丝氨酸/苏氨酸激酶活性。涉及多个过程，包括巨胞饮作用；调节细胞因子的产生；和对脂多糖的反应。作用于内耳发育的上游或内耳发育； p38MAPK 级联；和基因表达的正调控。位于细胞质和细胞核中。以多种结构表达，包括中枢神经系统；眼睛;泌尿生殖系统；直觉;和免疫系统。与人 MAPKAPK2（MAPK 活化蛋白激酶 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein serine/threonine kinase activity. Involved in several processes, including macropinocytosis; regulation of cytokine production; and response to lipopolysaccharide. Acts upstream of or within inner ear development; p38MAPK cascade; and positive regulation of gene expression. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Orthologous to human MAPKAPK2 (MAPK activated protein kinase 2). [provided by Alliance of Genome Resources, Apr 2022]

Mapkapk2 基因产物(1)

mRNA Protein Name
NM_008551.2 NP_032577.1 MAP kinase-activated protein kinase 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17906627 MGI
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
9628873 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in inflammatory response IMP
IMP: 通过突变表型推断
10559880 MGI
acts upstream of or within inner ear development IDA
IDA: 通过直接分析推断
21795542 MGI
acts upstream of or within mRNA stabilization IMP
IMP: 通过突变表型推断
11741878 MGI
acts upstream of macrophage cytokine production IMP
IMP: 通过突变表型推断
24020373 MGI
involved in macropinocytosis IMP
IMP: 通过突变表型推断
17906627 MGI
acts upstream of or within p38MAPK cascade IMP
IMP: 通过突变表型推断
24020373 MGI
acts upstream of or within positive regulation of macrophage cytokine production IMP
IMP: 通过突变表型推断
24020373 MGI
acts upstream of or within positive regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
24020373 MGI
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
9628873 MGI
involved in regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
10559880 MGI
involved in regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
10559880 MGI
involved in response to lipopolysaccharide IMP
IMP: 通过突变表型推断
10559880 MGI
involved in toll-like receptor signaling pathway IMP
IMP: 通过突变表型推断
17906627 MGI
acts upstream of tumor necrosis factor production IMP
IMP: 通过突变表型推断
24020373 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
9628873 MGI
located in nucleus IDA
IDA: 通过直接分析推断
9628873 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Mapkapk2 蛋白结构

STKc_MAPKAPK2

STKc_MAPKAPK2: cd14170 (46 - 348)

  • 0
  • 100
  • 200
  • 300
  • 386 a.a.
蛋白主名 其他名称

MAP kinase-activated protein kinase 2

MAPK-activated protein kinase 2

MAPKAP kinase 2

相关产品

Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-107427 PF-3644022 Inhibitor 99.65% 否
HY-12834A MK2-IN-1 hydrochloride Inhibitor 98.36% 否
HY-131249 MK2-IN-3 Inhibitor 99.58% 否
HY-148063 DB0614 98.80% 否
HY-112457 MK2-IN-3 hydrate Inhibitor ≥99.0% 否
HY-148061 DB1113 99.28% 否
HY-12834 MK2-IN-1 Inhibitor 99.04% 否
HY-147283 MK2-IN-4 Inhibitor / 否
HY-P10367 Ziptide / 否
HY-RS08131 MAPKAPK2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08132 Mapkapk2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS08133 Mapkapk2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Mapkapk2 NCBI NCBI:9261
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