1. Gene
  2. DHPS - deoxyhypusine synthase Gene

DHPS - deoxyhypusine synthase Gene

中文名称:脱氧海藻碱合酶

种属: Homo sapiens

同用名: DS; DHS; MIG13; NEDSSWI

基因 ID: 1725 | 基因类型: protein coding

关于 DHPS

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,672,470-12,681,880 (from NCBI)

This gene has 22 transcripts (splice variants), 221 orthologues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 15.4), brain (RPKM 14.5) and 25 other tissues.

功能概要

该基因编码一种形成 hypusine 所需的蛋白质,hypusine 是一种独特的氨基酸,由仅一种蛋白质 (真核翻译起始因子 5A) 的翻译后修饰形成。编码的蛋白质通过将亚精胺的丁胺部分转移到真核翻译起始因子 5A 前体的特定赖氨酸残基,形成中间体脱氧 hypusine 残基,从而催化 hypusine 形成的第一步。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供,2011 年 5 月]

This gene encodes a protein that is required for the formation of hypusine, a unique amino acid formed by the posttranslational modification of only one protein, eukaryotic translation initiation factor 5A. The encoded protein catalyzes the first step in hypusine formation by transferring the butylamine moiety of spermidine to a specific lysine residue of the eukaryotic translation initiation factor 5A precursor, forming an intermediate deoxyhypusine residue. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2011]

DHPS 基因产物(6)

mRNA Protein Name
NM_001206974.2 NP_001193903.1 deoxyhypusine synthase isoform d
NM_001369691.1 NP_001356620.1 deoxyhypusine synthase isoform e
NM_001369692.1 NP_001356621.1 deoxyhypusine synthase isoform f
NM_001369693.1 NP_001356622.1 deoxyhypusine synthase isoform g
NM_001930.4 NP_001921.1 deoxyhypusine synthase isoform a
NM_013406.3 NP_037538.1 deoxyhypusine synthase isoform b

DHPS 蛋白结构

DS

DS: Deoxyhypusine synthase (43 - 356)

  • 0
  • 100
  • 200
  • 300
  • 369 a.a.
蛋白主名 其他名称

deoxyhypusine synthase

migration-inducing gene 13

DHPS 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
DHPS P49366 RAB27B Homo sapiens O00194 25416956
种属内
DHPS P49366 RAB27B Homo sapiens O00194 25416956
种属内
DHPS P49366 ZNF138 Homo sapiens P52744-2 25416956
种属内
DHPS P49366 ZNF138 Homo sapiens P52744-2 25416956
种属内
DHPS P49366 ZNF138 Homo sapiens P52744 32296183
种属内
DHPS P49366 ZNF138 Homo sapiens P52744 32296183
种属内
DHPS P49366 ZNF138 Homo sapiens P52744 32296183
种属内
DHPS P49366 REL Homo sapiens Q04864-2 32296183
种属内
DHPS P49366 REL Homo sapiens Q04864-2 32296183
种属内
DHPS P49366 REL Homo sapiens Q04864-2 32296183
种属内
DHPS P49366 PTPRH Homo sapiens Q9HD43 25416956
种属内
DHPS P49366 PTPRH Homo sapiens Q9HD43 25416956
种属内
DHPS P49366 MEOX2 Homo sapiens Q6FHY5 32296183
种属内
DHPS P49366 MEOX2 Homo sapiens Q6FHY5 32296183
种属内
DHPS P49366 MEOX2 Homo sapiens Q6FHY5 32296183
种属内
DHPS P49366 RBP1 Homo sapiens P09455 32296183
种属内
DHPS P49366 RBP1 Homo sapiens P09455 32296183
种属内
DHPS P49366 REL Homo sapiens Q04864 25416956
种属内
DHPS P49366 RPL9 Homo sapiens P32969 16189514
种属内
DHPS P49366 RPL9 Homo sapiens P32969 25416956
种属内
DHPS P49366 RPL9 Homo sapiens P32969 32296183
种属内
DHPS P49366 RPL9 Homo sapiens P32969 25416956
种属内
DHPS P49366 RPL9 Homo sapiens P32969 32296183
种属内
DHPS P49366 EIF5A Homo sapiens P63241 32296183
种属内
DHPS P49366 EIF5A Homo sapiens P63241 25416956
种属内
DHPS P49366 EIF5A Homo sapiens P63241 32296183
种属内
DHPS P49366 EIF5A Homo sapiens P63241 25416956
种属内
DHPS P49366 EIF5A Homo sapiens P63241 32296183
种属内
DHPS P49366 LNX1 Homo sapiens Q8TBB1 32296183
种属内
DHPS P49366 MAPK3 Homo sapiens P27361 32296183
种属内
DHPS P49366 MAPK3 Homo sapiens P27361 32296183
种属内
DHPS P49366 NUDT18 Homo sapiens Q6ZVK8 19060904
种属内
DHPS P49366 NUDT18 Homo sapiens Q6ZVK8 16189514
种属内
DHPS P49366 NUDT18 Homo sapiens Q6ZVK8 19060904
种属内
DHPS P49366 NIF3L1 Homo sapiens Q9GZT8 19060904
种属内
DHPS P49366 NIF3L1 Homo sapiens Q9GZT8 19060904
种属内
DHPS P49366 NIF3L1 Homo sapiens Q9GZT8 16189514
种属内
DHPS P49366 NTAQ1 Homo sapiens Q96HA8 25416956
种属内
DHPS P49366 EIF5A2 Homo sapiens Q9GZV4 16189514
种属内
DHPS P49366 EIF5A2 Homo sapiens Q9GZV4 32296183
种属内
DHPS P49366 EIF5A2 Homo sapiens Q9GZV4 25416956
种属内
DHPS P49366 PAX6 Homo sapiens P26367 32296183
种属内
DHPS P49366 PAX6 Homo sapiens P26367 32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 DHPS 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70038 Deoxyhypusine synthase/DHS Protein, Human (His) P49366 (M1-D369) ≥95%

关联疾病

疾病名称 别名
Neurodevelopmental Disorder With Seizures And Speech And Walking Impairment

NEDSSWI

Pneumocystosis

Pneumocystis Jirovecii Pneumonia

Pneumocystis Carinii Pneumonia

Pneumocystis Pneumonia

Pulmonary Pneumocystosis

PCP

Pneumocystosis Pneumonia

Pneumonia Pneumocystis Carinii

Pneumonia, Pneumocystis

Pneumocystis Jiroveci Pneumonia

Plasmodium Falciparum Malaria

Falciparum Malaria

Malaria, Falciparum

Malaria Fever, Subtertian

Malignant Tertian Fever

Malaria Falciparum

Cerebral Malaria Nos

Cerebral Malaria

Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria

Whipple Disease

Intestinal Lipodystrophy

Whipple'S Disease

Intestinal Lipophagic Granulomatosis

Secondary Non-Tropical Sprue

Tropheryma Whippelii Infection

Whipples Disease

Pneumonia

Acute Pneumonia

Pneumonias

Infectious Pneumonia

Pn - [Pneumonia]

Lobar Pneumonia Nos

Multifocal Pneumonia

Orthostatic Pneumonia

Pneumonia Nos

Chronic Pneumonia Nos

Atypical Pneumonia

Passive Pneumonia

Purulent Pneumonia

Interstitial Lobar Pneumonia

Pneumonia, Unspecified

Pneumonia Due To Chlamydia

Pneumonia Due To Chlamydia Pneumoniae

Pneumonia Due To E. Coli

Escherichia Coli Lobar Pneumonia

Pneumonia Due To H. Influenzae

Pneumonia Due To Hemophilus Influenzae

Bronchopneumonia Due To H. Influenzae

Haemophilus Influenzae Lobar Pneumonia

Bronchopneumonia Due To Hemophilus Influenzae

Pseudomonal Pneumonia

Pseudomonas Pneumonia

Pseudomonas Lobar Pneumonia

Staphylococcal Pneumonia

Staphylococcus Pneumonia

Acute Staphylococcal Pneumonia

Staphylococcal Double Pneumonia

Staphylococcal Lobar Pneumonia

Staphylococcal Purulent Pneumonia

Staphylococcal Bronchopneumonia

Pneumococcal Pneumonia

Pneumococcus Pneumonia

Bronchopneumonia Due To S. Pneumoniae

Pneumococcal Lobar Pneumonia

Streptococcal Pneumoniae Pneumonia

Streptococcus Pneumoniae Lobar Pneumonia

Pyemic Pneumococcal Embolism With Pneumonia

Bronchopneumonia Due To Streptococcus Pneumoniae

Pneumonia Due To Streptococcus, Group B

Group B Streptococcal Pneumonia

Adenovirus Pneumonia

Adenoviral Pneumonia

Adenovirus Viral Pneumonia

Pneumonia Respiratory Syncytial Viral

Parainfluenza Viral Pneumonia

Parainfluenzal Pneumonia

Parainfluenza Virus Pneumonia

Human Metapneumovirus Pneumonia

Human Metapneumovirus Infection Resulting In Pneumonia

Pneumocystis Pneumonia

Plasma Cells Pneumonia

Cystoisosporiasis

Isosporiasis

Infection By Isospora Belli And Isospora Hominis

Isosporosis

Infection By Isospora Belli Or Isospora Hominis

Isospora Belli Or Hominis Infection

Coccidial Infestation

Coccidiosis

Coccidial Dysentery

Intestinal Coccidiosis Nos

Toxoplasmosis

Disseminated Toxoplasmosis

Multisystemic Disseminated Toxoplasmosis

Acquired Toxoplasmosis

Toxoplasmosis Disease Or Disorder

Infection By Toxoplasma Gondii

Toxoplasmal

Toxoplasma

Plasmodium Vivax Malaria

Malaria, Vivax

Malaria By Plasmodium Vivax

Vivax Malaria

Malaria Vivax

Meningococcal Infection

Meningococcal Disease

Meningococcal Infections

Neisseria Meningitidis Infection

Meningococcal Diseases

Meningococcus

Infection Due To Neisseria Meningitidis

Meningococcal Disease Nos

Meningococcal Infection Nos

Parasitic Protozoa Infectious Disease

Protozoan Infections

Mastigophora Infectious Disease

Sarcomastigophora Infectious Disease

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris DHPS VGNC VGNC:39931
Felis catus DHPS VGNC VGNC:78438
Mus musculus DHPS MGD MGI:2683592
Bos taurus DHPS VGNC VGNC:28038
Macaca mulatta DHPS VGNC VGNC:71795
Rattus norvegicus DHPS RGD RGD:1303326
Others DHPS NCBI