Myd88 - myeloid differentiation primary response gene 88 Gene

中文名称：骨髓分化初级反应基因88

种属: Mus musculus

关于 Myd88

功能概要

该基因编码的蛋白可启动 Toll 样受体结合活性和白细胞介素 1 受体结合活性。参与多个过程，包括细胞对氧化低密度脂蛋白颗粒刺激的反应；细胞因子产生的正调节；和对细菌的反应。作用于多个过程的上游或内部，包括细胞内信号转导的正向调节；调节细胞因子的产生；和对细菌的反应。位于胞质溶胶和质膜中。在大脑皮层表达；胚胎;和端脑。用于研究冠状病毒传染病。该基因的人类直系同源物与华氏巨球蛋白血症有关；结直肠癌；和原发性免疫缺陷病。与人 MyD88 同源（MYD88 先天免疫信号转导接头）。 [由基因组资源联盟提供，2022 年 4 月]

Enables Toll-like Receptor binding activity and interleukin-1 receptor binding activity. Involved in several processes, including cellular response to oxidised low-density lipoprotein particle stimulus; positive regulation of cytokine production; and response to bacterium. Acts upstream of or within several processes, including positive regulation of intracellular signal transduction; regulation of cytokine production; and response to bacterium. Located in cytosol and plasma membrane. Is expressed in cerebral cortex; embryo; and telencephalon. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in Waldenstroem's macroglobulinemia; colorectal carcinoma; and primary immunodeficiency disease. Orthologous to human MyD88 (MyD88 innate immune signal transduction adaptor). [provided by Alliance of Genome Resources, Apr 2022]