1. Gene
  2. Notch1 - notch 1 Gene

Notch1 - notch 1 Gene

中文名称:缺口 1

种属: Mus musculus

同用名: N1; Mis6; Tan1; lin-12; 9930111A19Rik

基因 ID: 18128 | 基因类型: protein coding

关于 Notch1

Chromosome 2: 26,347,915-26,406,675 reverse strand.GRCm39:CM000995.3

This gene has 11 transcripts (splice variants), 273 orthologues, 4 paralogues and is associated with 55 phenotypes. Broad expression in thymus adult (RPKM 56.2), lung adult (RPKM 46.1) and 21 other tissues.

功能概要

该基因编码的蛋白可启动多项功能,包括 Notch 绑定活动;染色质 DNA 结合活性;和转录共激活因子活性。参与多个过程,包括血管内皮细胞分化;心脏发育;和细胞分化的负调控。作用于多个过程的上游或内部,包括动物器官发育;神经系统发育;和管形态发生。位于多个细胞成分中,包括粘附连接;顶端质膜;和细胞表面。以多种结构表达,包括消化系统;心血管系统;中枢神经系统;泌尿生殖系统;和感觉器官。该基因的人类直系同源物与亚当斯-奥利弗综合征有关;成人 T 细胞白血病;和主动脉瓣疾病 1. 与人类 NOTCH1(缺口受体 1)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables several functions, including Notch binding activity; chromatin DNA binding activity; and transcription coactivator activity. Involved in several processes, including blood vessel endothelial cell differentiation; heart development; and negative regulation of cell differentiation. Acts upstream of or within several processes, including animal organ development; nervous system development; and tube morphogenesis. Located in several cellular components, including adherens junction; apical plasma membrane; and cell surface. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia; and aortic valve disease 1. Orthologous to human NOTCH1 (Notch receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

Notch1 基因产物(1)

mRNA Protein Name
NM_008714.3 NP_032740.3 neurogenic locus notch homolog protein 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Notch binding IPI
IPI: 通过物理相互作用推断
24667410 MGI
enables chromatin DNA binding IDA
IDA: 通过直接分析推断
17658278 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
15689374 MGI
enables enzyme binding IPI
IPI: 通过物理相互作用推断
17573339 MGI
enables enzyme inhibitor activity IDA
IDA: 通过直接分析推断
17573339 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
8749394 MGI
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
9111338 MGI
enables transcription regulator activator activity IDA
IDA: 通过直接分析推断
18299578 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Notch signaling pathway IDA
IDA: 通过直接分析推断
21419176 MGI
involved in Notch signaling pathway IGI
IGI: 通过遗传相互作用推断
20890042 MGI
acts upstream of or within Notch signaling pathway IMP
IMP: 通过突变表型推断
19154718 MGI
involved in Notch signaling pathway IMP
IMP: 通过突变表型推断
14701881 MGI
acts upstream of or within Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation IMP
IMP: 通过突变表型推断
19620969 MGI
involved in T-helper 17 type immune response IDA
IDA: 通过直接分析推断
28561022 MGI
acts upstream of or within anagen IMP
IMP: 通过突变表型推断
15978571 MGI
involved in aortic valve morphogenesis IGI
IGI: 通过遗传相互作用推断
23583836 MGI
involved in aortic valve morphogenesis IMP
IMP: 通过突变表型推断
26491108 MGI
acts upstream of apoptotic process IDA
IDA: 通过直接分析推断
15081359 MGI
acts upstream of or within apoptotic process involved in embryonic digit morphogenesis IMP
IMP: 通过突变表型推断
16245338 MGI
involved in arterial endothelial cell differentiation IMP
IMP: 通过突变表型推断
15107403 MGI
involved in atrioventricular node development IMP
IMP: 通过突变表型推断
21266778 MGI
involved in atrioventricular valve morphogenesis IMP
IMP: 通过突变表型推断
14701881 MGI
acts upstream of or within auditory receptor cell fate commitment IMP
IMP: 通过突变表型推断
19154718 MGI
acts upstream of or within axonogenesis IDA
IDA: 通过直接分析推断
15598981 MGI
acts upstream of or within axonogenesis IMP
IMP: 通过突变表型推断
16120638 MGI
acts upstream of or within branching morphogenesis of an epithelial tube IMP
IMP: 通过突变表型推断
15064243 MGI
acts upstream of calcium-ion regulated exocytosis IMP
IMP: 通过突变表型推断
19251639 MGI
involved in cardiac atrium morphogenesis IMP
IMP: 通过突变表型推断
20890042 MGI
involved in cardiac chamber formation IMP
IMP: 通过突变表型推断
20890042 MGI
involved in cardiac epithelial to mesenchymal transition IMP
IMP: 通过突变表型推断
17303760 MGI
involved in cardiac left ventricle morphogenesis IMP
IMP: 通过突变表型推断
20890042 MGI
involved in cardiac muscle cell myoblast differentiation IMP
IMP: 通过突变表型推断
20007915 MGI
involved in cardiac muscle cell proliferation IMP
IMP: 通过突变表型推断
21311046 MGI
involved in cardiac muscle tissue morphogenesis IMP
IMP: 通过突变表型推断
20007915 MGI
involved in cardiac right atrium morphogenesis IMP
IMP: 通过突变表型推断
20007915 MGI
acts upstream of or within cardiac right ventricle formation IMP
IMP: 通过突变表型推断
19620969 MGI
involved in cardiac septum morphogenesis IMP
IMP: 通过突变表型推断
20007915 MGI
involved in cardiac vascular smooth muscle cell development IMP
IMP: 通过突变表型推断
21311046 MGI
involved in cardiac ventricle morphogenesis IMP
IMP: 通过突变表型推断
21311046 MGI
acts upstream of or within cell differentiation IMP
IMP: 通过突变表型推断
14657333 MGI
involved in cell migration involved in endocardial cushion formation IMP
IMP: 通过突变表型推断
20890042 MGI
acts upstream of cell population proliferation IGI
IGI: 通过遗传相互作用推断
15509736 MGI
involved in cellular response to hypoxia IDA
IDA: 通过直接分析推断
18299578 MGI
involved in chemical synaptic transmission, postsynaptic IDA
IDA: 通过直接分析推断
21315255 MGI
involved in chemical synaptic transmission, postsynaptic IMP
IMP: 通过突变表型推断
21315255 MGI
involved in collecting duct development IEP
IEP: 通过表达模式推断
15821257 MGI
acts upstream of or within compartment pattern specification IMP
IMP: 通过突变表型推断
12001066 MGI
involved in coronary artery morphogenesis IMP
IMP: 通过突变表型推断
21311046 MGI
involved in coronary sinus valve morphogenesis IMP
IMP: 通过突变表型推断
26491108 MGI
involved in coronary vein morphogenesis IMP
IMP: 通过突变表型推断
21311046 MGI
acts upstream of or within determination of left/right symmetry IMP
IMP: 通过突变表型推断
7789282 MGI
involved in distal tubule development IEP
IEP: 通过表达模式推断
15821257 MGI
acts upstream of or within embryonic hindlimb morphogenesis IMP
IMP: 通过突变表型推断
16245338 MGI
acts upstream of or within embryonic limb morphogenesis IGI
IGI: 通过遗传相互作用推断
16169548 MGI
involved in endocardial cell differentiation IMP
IMP: 通过突变表型推断
20890042 MGI
acts upstream of or within endocardial cushion development IMP
IMP: 通过突变表型推断
14701881 MGI
involved in endocardial cushion morphogenesis IGI
IGI: 通过遗传相互作用推断
27107132 MGI
involved in endocardial cushion morphogenesis IMP
IMP: 通过突变表型推断
14701881 MGI
involved in endocardium development IMP
IMP: 通过突变表型推断
17336907 MGI
involved in endocardium morphogenesis IEP
IEP: 通过表达模式推断
16025100 MGI
involved in endocardium morphogenesis IMP
IMP: 通过突变表型推断
20890042 MGI
acts upstream of or within endoderm development IMP
IMP: 通过突变表型推断
14657333 MGI
acts upstream of or within epidermal cell fate specification IMP
IMP: 通过突变表型推断
15068794 MGI
acts upstream of or within epidermis development IGI
IGI: 通过遗传相互作用推断
15525534 MGI
acts upstream of or within epithelial cell fate commitment IMP
IMP: 通过突变表型推断
16107537 MGI
acts upstream of epithelial cell proliferation IGI
IGI: 通过遗传相互作用推断
15509736 MGI
acts upstream of epithelial cell proliferation IMP
IMP: 通过突变表型推断
25535395 MGI
acts upstream of or within epithelial to mesenchymal transition IMP
IMP: 通过突变表型推断
14701881 MGI
involved in epithelial to mesenchymal transition involved in endocardial cushion formation IMP
IMP: 通过突变表型推断
14701881 MGI
acts upstream of or within forebrain development IGI
IGI: 通过遗传相互作用推断
16120638 MGI
acts upstream of or within forebrain development IMP
IMP: 通过突变表型推断
16120638 MGI
acts upstream of or within foregut morphogenesis IMP
IMP: 通过突变表型推断
16107537 MGI
involved in gene expression IDA
IDA: 通过直接分析推断
28561022 MGI
acts upstream of or within glial cell differentiation IMP
IMP: 通过突变表型推断
15965470 MGI
involved in glomerular mesangial cell development IEP
IEP: 通过表达模式推断
15821257 MGI
involved in growth involved in heart morphogenesis IMP
IMP: 通过突变表型推断
20007915 MGI
acts upstream of or within hair follicle morphogenesis IMP
IMP: 通过突变表型推断
15525534 MGI
involved in heart looping IGI
IGI: 通过遗传相互作用推断
12730124 MGI
involved in heart trabecula morphogenesis IMP
IMP: 通过突变表型推断
20890042 MGI
involved in homeostasis of number of cells within a tissue IGI
IGI: 通过遗传相互作用推断
27107132 MGI
acts upstream of or within humoral immune response IGI
IGI: 通过遗传相互作用推断
17658279 MGI
acts upstream of or within in utero embryonic development IMP
IMP: 通过突变表型推断
7789282 MGI
acts upstream of or within inflammatory response to antigenic stimulus IGI
IGI: 通过遗传相互作用推断
17658279 MGI
acts upstream of or within inhibition of neuroepithelial cell differentiation IMP
IMP: 通过突变表型推断
15064243 MGI
involved in interleukin-17-mediated signaling pathway IDA
IDA: 通过直接分析推断
28561022 MGI
acts upstream of or within interleukin-4 production IGI
IGI: 通过遗传相互作用推断
17658279 MGI
acts upstream of keratinocyte differentiation IGI
IGI: 通过遗传相互作用推断
16618808 MGI
acts upstream of or within keratinocyte differentiation IMP
IMP: 通过突变表型推断
15068794 MGI
involved in left/right axis specification IGI
IGI: 通过遗传相互作用推断
12730124 MGI
acts upstream of or within liver development IMP
IMP: 通过突变表型推断
15226394 MGI
acts upstream of or within lung development IMP
IMP: 通过突变表型推断
15064243 MGI
involved in mesenchymal cell development IMP
IMP: 通过突变表型推断
17303760 MGI
involved in negative regulation of BMP signaling pathway IMP
IMP: 通过突变表型推断
19695258 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
16025100 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
19695258 MGI
involved in negative regulation of biomineral tissue development IDA
IDA: 通过直接分析推断
23583836 MGI
involved in negative regulation of biomineral tissue development IMP
IMP: 通过突变表型推断
26491108 MGI
acts upstream of or within negative regulation of calcium ion-dependent exocytosis IMP
IMP: 通过突变表型推断
19251639 MGI
acts upstream of or within negative regulation of canonical Wnt signaling pathway IMP
IMP: 通过突变表型推断
19620969 MGI
involved in negative regulation of cardiac muscle hypertrophy IMP
IMP: 通过突变表型推断
26491108 MGI
involved in negative regulation of catalytic activity IDA
IDA: 通过直接分析推断
17573339 MGI
involved in negative regulation of cell proliferation involved in heart valve morphogenesis IDA
IDA: 通过直接分析推断
26491108 MGI
involved in negative regulation of cell proliferation involved in heart valve morphogenesis IMP
IMP: 通过突变表型推断
26491108 MGI
involved in negative regulation of cold-induced thermogenesis IMP
IMP: 通过突变表型推断
25038826 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: 通过突变表型推断
25535395 MGI
involved in negative regulation of extracellular matrix constituent secretion IMP
IMP: 通过突变表型推断
26491108 MGI
involved in negative regulation of glial cell proliferation IDA
IDA: 通过直接分析推断
12666205 MGI
acts upstream of or within negative regulation of inner ear auditory receptor cell differentiation IMP
IMP: 通过突变表型推断
25535395 MGI
involved in negative regulation of myotube differentiation IMP
IMP: 通过突变表型推断
18299578 MGI
involved in negative regulation of neurogenesis IMP
IMP: 通过突变表型推断
18299578 MGI
acts upstream of or within negative regulation of neuron differentiation IGI
IGI: 通过遗传相互作用推断
10205173 MGI
acts upstream of or within negative regulation of neuron differentiation IMP
IMP: 通过突变表型推断
15064243 MGI
involved in negative regulation of oligodendrocyte differentiation IDA
IDA: 通过直接分析推断
12666205 MGI
involved in negative regulation of ossification IMP
IMP: 通过突变表型推断
21493891 MGI
involved in negative regulation of osteoblast differentiation IMP
IMP: 通过突变表型推断
19695258 MGI
acts upstream of or within negative regulation of photoreceptor cell differentiation IMP
IMP: 通过突变表型推断
16452096 MGI
involved in negative regulation of pro-B cell differentiation IMP
IMP: 通过突变表型推断
12032823 MGI
acts upstream of or within negative regulation of programmed cell death IMP
IMP: 通过突变表型推断
7789282 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12032823 MGI
involved in negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
14701881 MGI
acts upstream of or within neural tube development IMP
IMP: 通过突变表型推断
7789282 MGI
acts upstream of neuroendocrine cell differentiation IMP
IMP: 通过突变表型推断
15064243 MGI
acts upstream of neuron differentiation IGI
IGI: 通过遗传相互作用推断
10205173 MGI
acts upstream of neuron differentiation IMP
IMP: 通过突变表型推断
16120638 MGI
acts upstream of or within neuron differentiation IMP
IMP: 通过突变表型推断
9102301 MGI
acts upstream of or within neuron fate commitment IGI
IGI: 通过遗传相互作用推断
16120638 MGI
acts upstream of or within oligodendrocyte differentiation IMP
IMP: 通过突变表型推断
12186854 MGI
involved in pericardium morphogenesis IMP
IMP: 通过突变表型推断
14701881 MGI
involved in positive regulation of BMP signaling pathway IDA
IDA: 通过直接分析推断
20547764 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
9111338 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
12666205 MGI
acts upstream of or within positive regulation of Notch signaling pathway IDA
IDA: 通过直接分析推断
24667410 MGI
acts upstream of or within positive regulation of aorta morphogenesis IMP
IMP: 通过突变表型推断
18952909 MGI
acts upstream of or within positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
15081359 MGI
acts upstream of or within positive regulation of apoptotic process IGI
IGI: 通过遗传相互作用推断
16169548 MGI
involved in positive regulation of apoptotic process involved in morphogenesis IDA
IDA: 通过直接分析推断
26491108 MGI
involved in positive regulation of astrocyte differentiation IDA
IDA: 通过直接分析推断
12666205 MGI
involved in positive regulation of cardiac muscle cell proliferation IMP
IMP: 通过突变表型推断
20007915 MGI
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
20890042 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IGI
IGI: 通过遗传相互作用推断
15509736 MGI
involved in positive regulation of epithelial to mesenchymal transition IMP
IMP: 通过突变表型推断
20890042 MGI
involved in positive regulation of gene expression IGI
IGI: 通过遗传相互作用推断
23583836 MGI
acts upstream of or within positive regulation of keratinocyte differentiation IDA
IDA: 通过直接分析推断
17079689 MGI
acts upstream of or within positive regulation of keratinocyte differentiation IGI
IGI: 通过遗传相互作用推断
16618808 MGI
involved in positive regulation of receptor signaling pathway via JAK-STAT IDA
IDA: 通过直接分析推断
15156153 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12783854 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
19245366 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
16618808 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
14701881 MGI
acts upstream of or within positive regulation of transcription of Notch receptor target IGI
IGI: 通过遗传相互作用推断
12794108 MGI
involved in positive regulation of viral genome replication IMP
IMP: 通过突变表型推断
21191019 MGI
involved in positive regulation of viral transcription IMP
IMP: 通过突变表型推断
21191019 MGI
acts upstream of or within prostate gland epithelium morphogenesis IMP
IMP: 通过突变表型推断
16360140 MGI
involved in protein catabolic process IDA
IDA: 通过直接分析推断
28561022 MGI
involved in protein import into nucleus IDA
IDA: 通过直接分析推断
28561022 MGI
involved in pulmonary valve morphogenesis IGI
IGI: 通过遗传相互作用推断
27107132 MGI
involved in pulmonary valve morphogenesis IMP
IMP: 通过突变表型推断
26491108 MGI
acts upstream of or within regulation of Notch signaling pathway IGI
IGI: 通过遗传相互作用推断
24667410 MGI
involved in regulation of cell adhesion involved in heart morphogenesis IMP
IMP: 通过突变表型推断
14701881 MGI
involved in regulation of cell migration IMP
IMP: 通过突变表型推断
20890042 MGI
acts upstream of or within regulation of epithelial cell proliferation IGI
IGI: 通过遗传相互作用推断
25535395 MGI
acts upstream of or within regulation of epithelial cell proliferation IMP
IMP: 通过突变表型推断
16107537 MGI
acts upstream of or within regulation of epithelial cell proliferation involved in prostate gland development IMP
IMP: 通过突变表型推断
16360140 MGI
involved in regulation of extracellular matrix assembly IMP
IMP: 通过突变表型推断
21311046 MGI
acts upstream of or within regulation of gene expression IMP
IMP: 通过突变表型推断
9102301 MGI
acts upstream of or within regulation of inner ear auditory receptor cell differentiation IMP
IMP: 通过突变表型推断
25535395 MGI
acts upstream of or within regulation of neurogenesis IMP
IMP: 通过突变表型推断
9102301 MGI
involved in regulation of postsynaptic neurotransmitter receptor activity IDA
IDA: 通过直接分析推断
26635527 MGI
involved in regulation of postsynaptic neurotransmitter receptor activity IMP
IMP: 通过突变表型推断
26635527 MGI
acts upstream of or within regulation of somitogenesis IMP
IMP: 通过突变表型推断
7789282 MGI
acts upstream of or within regulation of stem cell proliferation IMP
IMP: 通过突变表型推断
16107537 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
15689374 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
25535395 MGI
involved in regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
20007915 MGI
involved in response to muramyl dipeptide IDA
IDA: 通过直接分析推断
21156799 MGI
acts upstream of retinal cone cell differentiation IMP
IMP: 通过突变表型推断
16452096 MGI
acts upstream of or within secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development IMP
IMP: 通过突变表型推断
16360140 MGI
acts upstream of or within skeletal muscle cell differentiation IMP
IMP: 通过突变表型推断
22147266 MGI
acts upstream of or within somatic stem cell division IDA
IDA: 通过直接分析推断
12717450 MGI
acts upstream of or within somatic stem cell division IGI
IGI: 通过遗传相互作用推断
15509736 MGI
acts upstream of or within sprouting angiogenesis IMP
IMP: 通过突变表型推断
15809373 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16618808 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
16618808 MGI
involved in vasculogenesis involved in coronary vascular morphogenesis IMP
IMP: 通过突变表型推断
21311046 MGI
acts upstream of or within venous blood vessel morphogenesis IMP
IMP: 通过突变表型推断
18952909 MGI
involved in venous endothelial cell differentiation IMP
IMP: 通过突变表型推断
20890042 MGI
involved in ventricular septum morphogenesis IGI
IGI: 通过遗传相互作用推断
27107132 MGI
involved in ventricular septum morphogenesis IMP
IMP: 通过突变表型推断
26491108 MGI
involved in ventricular trabecula myocardium morphogenesis IMP
IMP: 通过突变表型推断
17336907 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
21315255 MGI
is active in Schaffer collateral - CA1 synapse IMP
IMP: 通过突变表型推断
21315255 MGI
located in adherens junction IDA
IDA: 通过直接分析推断
24715457 MGI
located in apical plasma membrane IDA
IDA: 通过直接分析推断
24715457 MGI
located in cell periphery IDA
IDA: 通过直接分析推断
23284756 MGI
located in cell surface IDA
IDA: 通过直接分析推断
15574878 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
15965470 MGI
located in cytoplasmic vesicle IDA
IDA: 通过直接分析推断
24667410 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
24667410 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
26635527 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
26635527 MGI
located in nucleus IDA
IDA: 通过直接分析推断
10206645 MGI
located in nucleus IMP
IMP: 通过突变表型推断
20007915 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
17079689 MGI
is active in postsynaptic density membrane IDA
IDA: 通过直接分析推断
21315255 MGI
is active in postsynaptic density membrane IEP
IEP: 通过表达模式推断
21315255 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Notch1 蛋白结构

EGF_CA

EGF_CA: cd00054 (141 - 174)

EGF_CA

EGF_CA: cd00054 (177 - 215)

EGF_CA

EGF_CA: cd00054 (256 - 292)

EGF_CA

EGF_CA: cd00054 (294 - 331)

EGF_CA

EGF_CA: cd00054 (334 - 369)

EGF_CA

EGF_CA: cd00054 (411 - 449)

EGF_CA

EGF_CA: cd00054 (451 - 487)

EGF_CA

EGF_CA: cd00054 (489 - 525)

EGF_CA

EGF_CA: cd00054 (527 - 563)

EGF_CA

EGF_CA: cd00054 (565 - 600)

EGF_CA

EGF_CA: cd00054 (602 - 638)

EGF_CA

EGF_CA: cd00054 (640 - 674)

EGF_CA

EGF_CA: cd00054 (677 - 712)

EGF_CA

EGF_CA: cd00054 (716 - 749)

EGF_CA

EGF_CA: cd00054 (754 - 788)

EGF_CA

EGF_CA: cd00054 (790 - 826)

EGF_CA

EGF_CA: cd00054 (868 - 904)

EGF_CA

EGF_CA: cd00054 (906 - 942)

EGF_CA

EGF_CA: cd00054 (944 - 980)

EGF_CA

EGF_CA: cd00054 (987 - 1018)

EGF_CA

EGF_CA: cd00054 (1020 - 1056)

EGF_CA

EGF_CA: cd00054 (1066 - 1093)

EGF_CA

EGF_CA: cd00054 (1145 - 1179)

EGF_CA

EGF_CA: cd00054 (1183 - 1218)

EGF_CA

EGF_CA: cd00054 (1220 - 1264)

EGF_CA

EGF_CA: cd00054 (1266 - 1304)

NL

NL: smart00004 (1441 - 1478)

Notch

Notch: pfam00066 (1486 - 1521)

Notch

Notch: pfam00066 (1524 - 1560)

NOD

NOD: pfam06816 (1565 - 1620)

NODP

NODP: pfam07684 (1660 - 1718)

JMTM_Notch1

JMTM_Notch1: cd21702 (1709 - 1788)

ANKYR

ANKYR: COG0666 (1862 - 1971)

ANK

ANK: sd00045 (1869 - 1914)

ANK

ANK: sd00045 (1916 - 1947)

ANKYR

ANKYR: COG0666 (1920 - 2110)

Ank_2

Ank_2: pfam12796 (1921 - 2014)

ANK

ANK: sd00045 (1949 - 1980)

ANK

ANK: sd00045 (1983 - 2014)

ANK

ANK: sd00045 (2016 - 2080)

PHA03247

PHA03247: cl33720 (2110 - 2492)

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  • 2000
  • 2400
  • 2531 a.a.
蛋白主名 其他名称

neurogenic locus notch homolog protein 1

Motch A

Notch gene homolog 1

mT14

major type A protein

p300

重组 Notch1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71166 NOTCH1 Protein, Mouse (HEK293, His) Q01705 (A18-Q526) ≥95%
HY-P73324 NOTCH1 Protein, Mouse (sf9, His) Q01705 (A19-Q526) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Notch1 NCBI NCBI:4851