2. Gene
  3. Cdk12 - cyclin-dependent kinase 12 Gene

Cdk12 - cyclin-dependent kinase 12 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：细胞周期蛋白依赖性激酶 12

种属: Rattus norvegicus

同用名: Hgn; Crk7; Pksc; Crkrs

基因 ID: 192350 | 基因类型: protein coding

关于 Cdk12

Primary_assembly 10: 83,201,211-83,280,888 forward strand.mRatBN7.2:CM026983.1

This gene has 4 transcripts (splice variants), 206 orthologues, 24 paralogues and is associated with 6 phenotypes. Biased expression in Thymus (RPKM 211.9), Spleen (RPKM 175.4) and 9 other tissues.

功能概要

该基因编码的蛋白可启动细胞周期蛋白结合活性。参与 RNA 剪接和 RNA 剪接的调控。位于核斑点。核细胞周期蛋白依赖性蛋白激酶全酶复合物的一部分。与人 CDK12（细胞周期蛋白依赖性激酶 12）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables cyclin binding activity. Involved in RNA splicing and regulation of RNA splicing. Located in nuclear speck. Part of nuclear cyclin-dependent protein kinase holoenzyme complex. Orthologous to human CDK12 (cyclin dependent kinase 12). [provided by Alliance of Genome Resources, Apr 2022]

Cdk12 基因产物(2)

mRNA Protein Name
NM_138916.2 NP_620271.1 cyclin-dependent kinase 12 isoform 2
NM_001033867.2 NP_001029039.1 cyclin-dependent kinase 12 isoform 1

Cdk12 蛋白结构

STKc_CDK12

STKc_CDK12: cd07864 (714 - 1015)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1484 a.a.
蛋白主名 其他名称

cyclin-dependent kinase 12

CDC2-related kinase 7

CDC2-related protein kinase 7

Cdc2-related kinase, arginine/serine-rich

cell division cycle 2-related protein kinase 7

cell division protein kinase 12

hippyragranin

protein kinase for splicing component

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-138293 SY-5609 Inhibitor 99.66% Phase 1
Pre-clinical Phase
生物活性分子 (24)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-80013 THZ1 Inhibitor 99.84% 否
HY-103618 THZ531 Inhibitor 99.86% 否
HY-130250 SR-4835 Inhibitor 99.73% 否
HY-139039 BSJ-4-116 Inhibitor 98.73% 否
HY-80013A THZ1 Hydrochloride Inhibitor 99.06% 否
HY-112261 CDK12-IN-3 Inhibitor 99.86% 否
HY-112626 CDK12-IN-2 Inhibitor 99.36% 否
HY-117203A CDK12-IN-E9 Inhibitor 99.97% 否
HY-151110A PROTAC CDK12/13 Degrader-1 TFA Degrader 98.37% 否
HY-145072 BSJ-01-175 Inhibitor 99.45% 否
HY-139980 CDK9-IN-13 Inhibitor 99.94% 否
HY-139328 CDK12-IN-5 Inhibitor 99.01% 否
HY-151110 PROTAC CDK12/13 Degrader-1 Degrader 98.01% 否
HY-139329 CDK12-IN-6 Inhibitor 98.09% 否
HY-168555 YJ1206 Degrader / 否
HY-168556 YJ9069 Degrader / 否
HY-150641 CDK-IN-9 Inhibitor / 否
HY-142696 CDK6/PIM1-IN-1 Inhibitor / 否
HY-162706 BSJ-5-63 Degrader / 否
HY-162528 CDK12-IN-7 Inhibitor / 否
HY-139327 CDK12-IN-4 Inhibitor / 否
HY-155787 SHR5428 Inhibitor / 否
HY-151878 CDK7-IN-20 Inhibitor / 否
HY-168162 ZLC491 Degrader / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Cdk12 NCBI NCBI:51755
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