Ripk1 - receptor (TNFRSF)-interacting serine-threonine kinase 1 Gene

中文名称：受体 (TNFRSF) 相互作用的丝氨酸-苏氨酸激酶 1

种属: Mus musculus

同用名: RIP; Rinp; Rip1; RIP-1; D330015H01Rik

关于 Ripk1

功能概要

该基因编码的蛋白可启动蛋白质同二聚化活性和蛋白质丝氨酸/苏氨酸激酶活性。参与多个过程，包括坏死信号通路；心肌细胞增殖的负调节；和信号转导的调节。在几个过程的上游或内部起作用，包括 I-kappaB 激酶/NF-kappaB 信号的正向调节；外源性凋亡信号通路的调节；和参与坏死过程的核糖体组装。预计位于几种细胞成分中，包括细胞质；膜筏；和线粒体。预计是死亡诱导信号复合体的一部分；受体复合体；和核糖体。以多种结构表达，包括中枢神经系统；心;肝;肺;和尾巴。该基因与免疫缺陷 57 相关的人类直向同源基因。与人类 RIPK1（受体相互作用的丝氨酸/苏氨酸激酶 1）直向同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein homodimerization activity and protein serine/threonine kinase activity. Involved in several processes, including necroptotic signaling pathway; negative regulation of cardiac muscle cell proliferation; and regulation of signal transduction. Acts upstream of or within several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; regulation of extrinsic apoptotic signaling pathway; and ripoptosome assembly involved in necroptotic process. Predicted to be located in several cellular components, including cytosol; membrane raft; and mitochondrion. Predicted to be part of death-inducing signaling complex; receptor complex; and ripoptosome. Is expressed in several structures, including central nervous system; heart; liver; lung; and tail. Human ortholog(s) of this gene implicated in immunodeficiency 57. Orthologous to human RIPK1 (receptor interacting serine/threonine kinase 1). [provided by Alliance of Genome Resources, Apr 2022]