1. Gene
  2. Sstr2 - somatostatin receptor 2 Gene

Sstr2 - somatostatin receptor 2 Gene

中文名称:生长抑素受体 2

种属: Mus musculus

同用名: SS2R; sst2; SRIF-1; SSTR-2; Smstr2; Smstr-2

基因 ID: 20606 | 基因类型: protein coding

关于 Sstr2

Chromosome 11: 113,510,168-113,516,854 forward strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 264 orthologues, 15 paralogues and is associated with 32 phenotypes. Biased expression in whole brain E14.5 (RPKM 13.8), CNS E14 (RPKM 13.2) and 13 other tissues.

功能概要

该基因编码的蛋白质是生长抑素的受体,它在许多位点起作用以抑制多种激素和其他分泌蛋白的释放。编码的蛋白质是具有七个跨膜片段的受体超家族的成员,参与许多过程,包括腺苷酸环化酶抑制、磷酸酪氨酸磷酸酶刺激以及钙进入和细胞生长的抑制。已发现该基因的两个转录本变体编码不同的亚型。 [RefSeq 提供,2015 年 9 月]

The protein encoded by this gene is a receptor for somatostatin, which acts at many sites to inhibit the release of several Hormones and Other secretory proteins. The encoded protein is a member of the superfamily of receptors having seven transmembrane segments and is involved in many processes, including adenylyl cyclase inhibition, phosphotyrosine Phosphatase stimulation, and inhibition of calcium entry and cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Sstr2 基因产物(2)

mRNA Protein Name
NM_009217.5 NP_033243.2 somatostatin receptor type 2 isoform B
NM_001042606.3 NP_001036071.1 somatostatin receptor type 2 isoform A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables somatostatin receptor activity IDA
IDA: 通过直接分析推断
1346068 MGI
enables somatostatin receptor activity IMP
IMP: 通过突变表型推断
7929134 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
7929134 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
9166719 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Sstr2 蛋白结构

7tmA_SSTR2

7tmA_SSTR2: cd15971 (43 - 322)

7tmA_SSTR2

7tmA_SSTR2: cd15971 (44 - 70)

7tmA_SSTR2

7tmA_SSTR2: cd15971 (77 - 103)

7tmA_SSTR2

7tmA_SSTR2: cd15971 (114 - 144)

7tmA_SSTR2

7tmA_SSTR2: cd15971 (156 - 178)

7tmA_SSTR2

7tmA_SSTR2: cd15971 (204 - 233)

7tmA_SSTR2

7tmA_SSTR2: cd15971 (248 - 278)

7tmA_SSTR2

7tmA_SSTR2: cd15971 (290 - 315)

  • 0
  • 100
  • 200
  • 300
  • 369 a.a.
蛋白主名 其他名称

somatostatin receptor type 2

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sstr2 NCBI NCBI:6752