2. Gene
  3. Pde2a - phosphodiesterase 2A, cGMP-stimulated Gene

Pde2a - phosphodiesterase 2A, cGMP-stimulated Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：磷酸二酯酶 2A，cGMP 刺激

种属: Mus musculus

同用名: cGSPDE; CGS-PDE

基因 ID: 207728 | 基因类型: protein coding

关于 Pde2a

Chromosome 7: 101,060,093-101,162,026 forward strand.GRCm39:CM001000.3

This gene has 1 transcript (splice variant). Broad expression in adrenal adult (RPKM 43.4), cortex adult (RPKM 43.1) and 24 other tissues.

功能概要

该基因编码的蛋白可启动多种功能，包括 3',5'-环状核苷酸磷酸二酯酶活性； GAF域绑定活动；和环核苷酸结合活性。涉及多个过程，包括cGMP分解代谢过程；环核苷酸介导的信号；和细胞内信号转导的负调节。作用于脂多糖细胞反应的上游或内部；循环系统发育；和调节一氧化氮介导的信号转导。位于几种细胞成分中，包括线粒体；细胞质的核周区；和突触前膜。以多种结构表达，包括泌尿生殖系统；直觉;淋巴系统；神经系统;和感觉器官。与人 PDE2A（磷酸二酯酶 2A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including 3',5'-cyclic-nucleotide phosphodiesterase activity; GAF domain binding activity; and cyclic nucleotide binding activity. Involved in several processes, including cGMP catabolic process; cyclic-nucleotide-mediated signaling; and negative regulation of intracellular signal transduction. Acts upstream of or within cellular response to lipopolysaccharide; circulatory system development; and regulation of nitric oxide mediated signal transduction. Located in several cellular components, including mitochondrion; perinuclear region of cytoplasm; and presynaptic membrane. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system; nervous system; and sensory organ. Orthologous to human PDE2A (phosphodiesterase 2A). [provided by Alliance of Genome Resources, Apr 2022]

Pde2a 基因产物(5)

mRNA Protein Name
NM_001008548.5 NP_001008548.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A3
NM_001143848.3 NP_001137320.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 6
NM_001243757.2 NP_001230686.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A1
NM_001143849.3 NP_001137321.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform PDE2A2 precursor
NM_001243758.2 NP_001230687.1 cGMP-dependent 3',5'-cyclic phosphodiesterase isoform 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3',5'-cGMP-stimulated cyclic-nucleotide phosphodiesterase activity IDA
IDA: 通过直接分析推断
15210692 MGI
enables 3',5'-cyclic-AMP phosphodiesterase activity IMP
IMP: 通过突变表型推断
21724846 MGI
enables 3',5'-cyclic-GMP phosphodiesterase activity IMP
IMP: 通过突变表型推断
21724846 MGI
enables GAF domain binding IDA
IDA: 通过直接分析推断
12271124 MGI
enables cAMP binding IMP
IMP: 通过突变表型推断
15210692 MGI
enables cGMP binding IDA
IDA: 通过直接分析推断
12271124 MGI
enables cGMP binding IMP
IMP: 通过突变表型推断
15210692 MGI
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
12271124 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within aorta development IMP
IMP: 通过突变表型推断
25807483 MGI
involved in cAMP-mediated signaling IDA
IDA: 通过直接分析推断
15210692 MGI
involved in cGMP catabolic process IMP
IMP: 通过突变表型推断
19632989 MGI
involved in cGMP-mediated signaling IDA
IDA: 通过直接分析推断
15210692 MGI
acts upstream of or within cardiac septum development IMP
IMP: 通过突变表型推断
25807483 MGI
involved in cellular response to lipopolysaccharide IEP
IEP: 通过表达模式推断
21571906 MGI
involved in cellular response to mechanical stimulus IDA
IDA: 通过直接分析推断
21571906 MGI
acts upstream of or within coronary vasculature development IMP
IMP: 通过突变表型推断
25807483 MGI
acts upstream of or within heart development IMP
IMP: 通过突变表型推断
25807483 MGI
acts upstream of or within heart valve development IMP
IMP: 通过突变表型推断
25807483 MGI
involved in intracellular signal transduction IMP
IMP: 通过突变表型推断
28463107 MGI
involved in negative regulation of cAMP-mediated signaling IMP
IMP: 通过突变表型推断
21571906 MGI
involved in negative regulation of cGMP-mediated signaling IMP
IMP: 通过突变表型推断
21724846 MGI
involved in negative regulation of oxidative phosphorylation IMP
IMP: 通过突变表型推断
21724846 MGI
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
21571906 MGI
involved in positive regulation of inflammatory response IMP
IMP: 通过突变表型推断
21571906 MGI
involved in regulation of mitochondrion organization IMP
IMP: 通过突变表型推断
28463107 MGI
acts upstream of or within regulation of nitric oxide mediated signal transduction IGI
IGI: 通过遗传相互作用推断
16150726 MGI
acts upstream of or within ventricular septum development IMP
IMP: 通过突变表型推断
25807483 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
19632989 MGI
located in axon IDA
IDA: 通过直接分析推断
8586960 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
19506089 MGI
located in cytosol IDA
IDA: 通过直接分析推断
17329248 MGI
located in dendrite IDA
IDA: 通过直接分析推断
8586960 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
19632989 MGI
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
28463107 MGI
located in mitochondrial matrix IDA
IDA: 通过直接分析推断
21724846 MGI
located in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
28463107 MGI
located in mitochondrion IDA
IDA: 通过直接分析推断
28463107 MGI
located in nucleus IDA
IDA: 通过直接分析推断
19632989 MGI
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
19632989 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
19632989 MGI
located in presynaptic membrane IDA
IDA: 通过直接分析推断
19506089 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Pde2a 蛋白结构

GAF

GAF: smart00065 (234 - 385)

GAF

GAF: smart00065 (407 - 556)

PDEase_I

PDEase_I: pfam00233 (653 - 886)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 939 a.a.
蛋白主名 其他名称

cGMP-dependent 3',5'-cyclic phosphodiesterase

cyclic GMP-stimulated phosphodiesterase

相关产品

Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
HY-111371 PF-05180999 Inhibitor 99.97% Phase 1
HY-103493 TAK-915 Inhibitor 99.74% Phase 1
Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-102050 PF-05085727 Inhibitor 99.60% 否
HY-132993 Hcyb1 Inhibitor 98.20% 否
HY-120710 DNS-8254 Inhibitor / 否
HY-142660 PDE2A-IN-1 Inhibitor / 否
HY-RS10213 PDE2A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10214 Pde2a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10215 Pde2a Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-124173 PF-06815189 Inhibitor / 否
HY-112704 PDE5-IN-2 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pde2a NCBI NCBI:5138
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