2. Gene
  3. Suv39h1 - suppressor of variegation 3-9 1 Gene

Suv39h1 - suppressor of variegation 3-9 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: mIS6; KMT1A; DXHXS7466e; H3-K9-HMTase 1

基因 ID: 20937 | 基因类型: protein coding

关于 Suv39h1

功能概要

Enables RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and Histone Methyltransferase activity (H3-K9 specific). Involved in histone H3-K9 methylation; negative regulation of circadian rhythm; and negative regulation of transcription, DNA-templated. Acts upstream of or within several processes, including blastocyst hatching; positive regulation of histone H3-K9 trimethylation; and regulation of cellular response to stress. Located in heterochromatin and nucleus. Part of chromatin silencing complex. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; integumental system; and nervous system. Orthologous to human SUV39H1 (SUV39H1 histone lysine methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Suv39h1 基因产物(3)

mRNA Protein Name
NM_001290716.3 NP_001277645.1 histone-lysine N-methyltransferase SUV39H1 isoform 2
NM_001358237.2 NP_001345166.1 histone-lysine N-methyltransferase SUV39H1 isoform 3
NM_011514.3 NP_035644.1 histone-lysine N-methyltransferase SUV39H1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
21402781 MGI
enables histone H3K9 methyltransferase activity IDA
IDA: 通过直接分析推断
10949293 MGI
enables histone H3K9 methyltransferase activity IGI
IGI: 通过遗传相互作用推断
15788566 MGI
enables histone H3K9 methyltransferase activity IMP
IMP: 通过突变表型推断
23695662 MGI
enables histone H3K9me2 methyltransferase activity IGI
IGI: 通过遗传相互作用推断
23451023 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16688220 MGI
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
24413057 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within blastocyst hatching IMP
IMP: 通过突变表型推断
27869233 MGI
involved in circadian rhythm IMP
IMP: 通过突变表型推断
24413057 MGI
acts upstream of or within determination of adult lifespan IGI
IGI: 通过遗传相互作用推断
23695662 MGI
involved in negative regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
24413057 MGI
involved in negative regulation of gene expression, epigenetic IMP
IMP: 通过突变表型推断
24413057 MGI
acts upstream of or within regulation of DNA repair IMP
IMP: 通过突变表型推断
23695662 MGI
acts upstream of or within regulation of bone mineralization IGI
IGI: 通过遗传相互作用推断
23695662 MGI
acts upstream of or within regulation of cellular senescence IMP
IMP: 通过突变表型推断
23695662 MGI
acts upstream of or within regulation of multicellular organism growth IGI
IGI: 通过遗传相互作用推断
23695662 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of chromatin silencing complex IDA
IDA: 通过直接分析推断
11788710 MGI
located in heterochromatin IDA
IDA: 通过直接分析推断
18004385 MGI
located in nucleus IDA
IDA: 通过直接分析推断
18004385 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

histone-lysine N-methyltransferase SUV39H1

Suv39h histone methyltransferase

histone H3-K9 methyltransferase 1

position-effect variegation 3-9 homolog

su(var)3-9 homolog 1

suppressor of variegation 3-9 homolog 1

Suv39h1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Suv39h1 O54864 Myod1 Mus musculus P10085
Anti Bait CoIP
16858404
种属内
Suv39h1 O54864 Myod1 Mus musculus P10085
Pull Down
16858404
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-150190 F5446 99.38% 否
HY-15647 BRD9539 Inhibitor 99.74% 否
HY-RS14051 SUV39H1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Suv39h1 NCBI NCBI:6839
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