1. Gene
  2. Tacr1 - tachykinin receptor 1 Gene

Tacr1 - tachykinin receptor 1 Gene

中文名称:速激肽受体 1

种属: Mus musculus

同用名: Spr; Nk1r; Tac1r

基因 ID: 21336 | 基因类型: protein coding

关于 Tacr1

Chromosome 6: 82,379,315-82,537,085 forward strand.GRCm39:CM000999.3

This gene has 3 transcripts (splice variants), 270 orthologues, 55 paralogues and is associated with 34 phenotypes. Low expression observed in reference dataset.

功能概要

该基因编码速激肽受体 P 物质,也称为神经激肽 1。该基因属于速激肽受体基因家族,其特征是与 G 蛋白相互作用并包含七个疏水跨膜区。该受体与一氧化氮的形成有关,并且定位于胆碱能和氮能神经元以及平滑肌细胞。 [RefSeq 提供,2010 年 3 月]

This gene encodes the receptor for the tachykinin, substance P, also referred to as neurokinin 1. This gene belongs to a gene family of tachykinin receptors which are characterized by interactions with G proteins and contain seven hydrophobic transmembrane regions. This receptor has been associated with nitric oxide formation, and it has been localized to cholinergic and nitrergic neurons as well as on smooth muscle cells. [provided by RefSeq, Mar 2010]

Tacr1 基因产物(1)

mRNA Protein Name
NM_009313.5 NP_033339.2 substance-P receptor
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of uterine smooth muscle contraction IDA
IDA: 通过直接分析推断
15647454 MGI
acts upstream of or within response to pain IMP
IMP: 通过突变表型推断
11805341 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell periphery IDA
IDA: 通过直接分析推断
12383972 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Tacr1 蛋白结构

7tm_GPCRs

7tm_GPCRs: cl28897 (32 - 315)

7tm_GPCRs

7tm_GPCRs: cd14964 (34 - 58)

7tm_GPCRs

7tm_GPCRs: cd14964 (67 - 89)

7tm_GPCRs

7tm_GPCRs: cd14964 (105 - 127)

7tm_GPCRs

7tm_GPCRs: cd14964 (148 - 164)

7tm_GPCRs

7tm_GPCRs: cd14964 (193 - 216)

7tm_GPCRs

7tm_GPCRs: cd14964 (246 - 268)

7tm_GPCRs

7tm_GPCRs: cd14964 (283 - 308)

  • 0
  • 100
  • 200
  • 300
  • 407 a.a.
蛋白主名 其他名称

substance-P receptor

Nk1 receptor

neurokinin receptor 1

substance P receptor

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tacr1 NCBI NCBI:6869