2. Gene
  3. Nr2c1 - nuclear receptor subfamily 2, group C, member 1 Gene

Nr2c1 - nuclear receptor subfamily 2, group C, member 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: TR2; 80.3; Eenr; Tr2-11; 4831444H07Rik

基因 ID: 22025 | 基因类型: protein coding

关于 Nr2c1

功能概要

Enables several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; histone deacetylase binding activity; and protein homodimerization activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of retinoic acid receptor signaling pathway. Located in PML body. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; jaw; and sensory organ. Orthologous to human NR2C1 (nuclear receptor subfamily 2 group C member 1). [provided by Alliance of Genome Resources, Apr 2022]

Nr2c1 基因产物(1)

mRNA Protein Name
NM_011629.3 NP_035759.3 nuclear receptor subfamily 2 group C member 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
9071982 MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
9369481 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
9369481 MGI
enables histone deacetylase binding IPI
IPI: 通过物理相互作用推断
11463856 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9774688 MGI
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
9369481 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
8858600 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
8858600 MGI
involved in positive regulation of retinoic acid receptor signaling pathway IDA
IDA: 通过直接分析推断
16130175 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in PML body IDA
IDA: 通过直接分析推断
18682553 MGI
located in nucleus IDA
IDA: 通过直接分析推断
9795341 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

nuclear receptor subfamily 2 group C member 1

80-3 cNDA

early embryonic nuclear receptor

mTR2

nuclear receptor subfamily 2, group H, member 1

orphan nuclear receptor TR2

orphan receptor, TR2-11

testicular receptor 2

Nr2c1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Nr2c1 Q505F1 Pml Mus musculus Q8BSJ6
Anti Tag CoIP
18682553
种属内
Nr2c1 Q505F1 Pml Mus musculus Q8BSJ6
Anti Bait CoIP
18682553
种属内
Nr2c1 Q505F1 Nrip1 Mus musculus Q8CBD1
Anti Tag CoIP
17187077
种属内
Nr2c1 Q505F1 Nrip1 Mus musculus Q8CBD1
Y2H
17187077
种属内
Nr2c1 Q505F1 Nrip1 Mus musculus Q8CBD1
Y2H
18682553
种属内
Nr2c1 Q505F1 Kat2b Mus musculus Q9JHD1
Interaction Detect
17187077
种属内
Nr2c1 Q505F1 Kat2b Mus musculus Q9JHD1
Y2H
17187077
种属内
Nr2c1 Q505F1 Kat2b Mus musculus Q9JHD1
Y2H
18682553
种属内
Nr2c1 Q505F1 Pias1 Mus musculus O88907
Y2H
17187077
种属内
Nr2c1 Q505F1 Pias1 Mus musculus O88907
Pull Down
17187077
种属内
Nr2c1 Q505F1 Pias1 Mus musculus O88907
Anti Bait CoIP
17187077
种属内
Nr2c1 Q505F1 Pml Mus musculus Q60953
Anti Bait CoIP
17187077
种属内
Nr2c1 Q505F1 Sumo1 Mus musculus P63166
Anti Bait CoIP
17187077
种属内
Nr2c1 Q505F1 Sumo1 Mus musculus P63166
Anti Bait CoIP
18682553
种属内
Nr2c1 Q505F1 Sumo1 Mus musculus P63166
Interaction Detect
17187077
种属内
Nr2c1 Q505F1 Ube2i Mus musculus P63280
Pull Down
17187077
种属内
Nr2c1 Q505F1 Ube2i Mus musculus P63280
Y2H
17187077
种属内
Nr2c1 Q505F1 Ube2i Mus musculus P63280
Anti Bait CoIP
17187077
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09536 NR2C1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nr2c1 NCBI NCBI:7181
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