2. Gene
  3. SLC29A4 - solute carrier family 29 member 4 Gene

SLC29A4 - solute carrier family 29 member 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 29 成员 4

种属: Homo sapiens

同用名: ENT4; PMAT

基因 ID: 222962 | 基因类型: protein coding

关于 SLC29A4

Cytogenetic location: 7p22.1 Genomic coordinates (GRCh38): 7:5,282,943-5,306,912 (from NCBI)

This gene has 6 transcripts (splice variants), 196 orthologues and 3 paralogues. Biased expression in fat (RPKM 35.4), adrenal (RPKM 3.7) and 4 other tissues.

功能概要

该基因编码 SLC29A/ENT 转运蛋白家族的成员。编码的膜蛋白催化单胺再摄取到突触前神经元，从而决定单胺神经信号的强度和持续时间。它已被证明可以运输多种化合物，包括血清素、多巴胺和神经毒素 1-甲基-4-苯基吡啶。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 7 月]

This gene encodes a member of the SLC29A/ENT transporter protein family. The encoded membrane protein catalyzes the reuptake of monoamines into presynaptic neurons, thus determining the intensity and duration of monoamine neural signaling. It has been shown to transport several compounds, including serotonin, dopamine, and the neurotoxin 1-methyl-4-phenylpyridinium. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

SLC29A4 基因产物(3)

mRNA Protein Name
NM_001040661.3 NP_001035751.1 equilibrative nucleoside transporter 4 isoform 1
NM_001300847.3 NP_001287776.1 equilibrative nucleoside transporter 4 isoform 2
NM_153247.4 NP_694979.2 equilibrative nucleoside transporter 4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables efflux transmembrane transporter activity IDA
IDA: 通过直接分析推断
16099839 GOA
enables efflux transmembrane transporter activity IMP
IMP: 通过突变表型推断
31842924 GOA
enables monoamine transmembrane transporter activity IDA
IDA: 通过直接分析推断
15448143 GOA
enables monoamine transmembrane transporter activity IMP
IMP: 通过突变表型推断
23505051 GOA
enables neurotransmitter transmembrane transporter activity IDA
IDA: 通过直接分析推断
15448143 GOA
enables neurotransmitter transmembrane transporter activity IMP
IMP: 通过突变表型推断
23505051 GOA
enables organic acid transmembrane transporter activity IDA
IDA: 通过直接分析推断
26376205 GOA
enables organic cation transmembrane transporter activity IDA
IDA: 通过直接分析推断
16099839 GOA
enables xenobiotic transmembrane transporter activity IDA
IDA: 通过直接分析推断
26376205 GOA
enables xenobiotic transmembrane transporter activity IMP
IMP: 通过突变表型推断
31842924 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in adenosine transport IDA
IDA: 通过直接分析推断
16873718 GOA
involved in dopamine transport IDA
IDA: 通过直接分析推断
15448143 GOA
involved in dopamine uptake IDA
IDA: 通过直接分析推断
20858707 GOA
involved in epinephrine transport IDA
IDA: 通过直接分析推断
15448143 GOA
involved in epinephrine uptake IDA
IDA: 通过直接分析推断
20858707 GOA
involved in export across plasma membrane IMP
IMP: 通过突变表型推断
31842924 GOA
involved in histamine transport IDA
IDA: 通过直接分析推断
16099839 GOA
involved in histamine uptake IDA
IDA: 通过直接分析推断
20858707 GOA
involved in histamine uptake IMP
IMP: 通过突变表型推断
23505051 GOA
involved in monoamine transport IMP
IMP: 通过突变表型推断
23505051 GOA
involved in neurotransmitter transport IDA
IDA: 通过直接分析推断
20858707 GOA
involved in norepinephrine transport IDA
IDA: 通过直接分析推断
15448143 GOA
involved in norepinephrine uptake IDA
IDA: 通过直接分析推断
20858707 GOA
involved in organic acid transmembrane transport IDA
IDA: 通过直接分析推断
26376205 GOA
involved in organic cation transport IDA
IDA: 通过直接分析推断
26376205 GOA
involved in serotonin transport IDA
IDA: 通过直接分析推断
15448143 GOA
involved in serotonin uptake IDA
IDA: 通过直接分析推断
20858707 GOA
involved in xenobiotic transport IDA
IDA: 通过直接分析推断
20858707 GOA
involved in xenobiotic transport IMP
IMP: 通过突变表型推断
31842924 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
17018840 GOA
located in basolateral plasma membrane IDA
IDA: 通过直接分析推断
26376205 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
20858707 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC29A4 蛋白结构

Nucleoside_tran

Nucleoside_tran: Nucleoside transporter (172 - 504)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 530 a.a.
蛋白主名 其他名称

equilibrative nucleoside transporter 4

plasma membrane monoamine transporter

关联疾病

疾病名称 别名
Ocular Hyperemia

Hyperemia Eye

Hyperemia Of Conjunctiva
Brain Compression

Compression Of Brain
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13156 SLC29A4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SLC29A4 MGD MGI:2385330
Rattus norvegicus SLC29A4 RGD RGD:1310545
Felis catus SLC29A4 VGNC VGNC:65298
Canis familiaris SLC29A4 VGNC VGNC:46336
Bos taurus SLC29A4 VGNC VGNC:34795
Macaca mulatta SLC29A4 VGNC VGNC:77562
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