Vdr - vitamin D (1,25-dihydroxyvitamin D3) receptor Gene

中文名称：维生素 D (1 ,25-二羟基维生素 D3) 受体

种属: Mus musculus

同用名: Nr1i1

关于 Vdr

功能概要

该基因编码的蛋白可启动 DNA 结合活性和核受体活性。参与调节骨化二醇 1-单加氧酶活性。作用于多个过程的上游或内部，包括肠道吸收；乳腺发育；和参与乳腺退化的细胞凋亡过程的正调节。预计位于多个细胞成分中，包括 T 管；染色质；和核腔。预计是 RNA 聚合酶 II 转录调节复合物和受体复合物的一部分。预测与 caveola 共定位。以多种结构表达，包括消化系统；后肾;神经系统;感觉器官；和骨架。用于研究骨质疏松症和佝偻病。该基因的人类直系同源物与多种疾病有关，包括自身免疫性疾病（多种）；癌（多发性）；脂质贮积症（多种）；黑色素瘤（多发性）；和肺结核（多发）。与人类 VDR（维生素 D 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA binding activity and nuclear receptor activity. Involved in regulation of calcidiol 1-monooxygenase activity. Acts upstream of or within several processes, including intestinal absorption; mammary gland development; and positive regulation of apoptotic process involved in mammary gland involution. Predicted to be located in several cellular components, including T-tubule; chromatin; and nuclear lumen. Predicted to be part of RNA polymerase II transcription regulator complex and receptor complex. Predicted to colocalize with caveola. Is expressed in several structures, including alimentary system; metanephros; nervous system; sensory organ; and skeleton. Used to study osteoporosis and rickets. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); lipid storage disease (multiple); melanoma (multiple); and tuberculosis (multiple). Orthologous to human VDR (vitamin D receptor). [provided by Alliance of Genome Resources, Apr 2022]