2. Gene
  3. Dok7 - docking protein 7 Gene

Dok7 - docking protein 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Oit5; Dok-7; EF-12; A930013K19Rik

基因 ID: 231134 | 基因类型: protein coding

关于 Dok7

功能概要

Enables phosphatidylinositol binding activity and protein kinase binding activity. Involved in positive regulation of protein tyrosine kinase activity. Acts upstream of or within neuromuscular junction development; positive regulation of protein phosphorylation; and receptor clustering. Located in neuromuscular junction. Is expressed in several structures, including central nervous system; heart; skeletal muscle; and testis. Used to study congenital myasthenic syndrome 10. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 10 and fetal akinesia deformation sequence syndrome 3. Orthologous to human DOK7 (docking protein 7). [provided by Alliance of Genome Resources, Apr 2022]

Dok7 基因产物(5)

mRNA Protein Name
NM_001348274.1 NP_001335203.1 protein Dok-7 isoform 2
NM_001348275.1 NP_001335204.1 protein Dok-7 isoform 3
NM_001348276.1 NP_001335205.1 protein Dok-7 isoform 4
NM_001348478.1 NP_001335407.1 protein Dok-7 isoform 1
NM_172708.4 NP_766296.1 protein Dok-7 isoform 5
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatidylinositol binding IDA
IDA: 通过直接分析推断
20603078 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16794080 MGI
enables protein kinase binding IDA
IDA: 通过直接分析推断
20603078 MGI
enables signaling adaptor activity IDA
IDA: 通过直接分析推断
16794080 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in enzyme-linked receptor protein signaling pathway IDA
IDA: 通过直接分析推断
18848351 MGI
involved in enzyme-linked receptor protein signaling pathway IGI
IGI: 通过遗传相互作用推断
8653787 MGI
involved in enzyme-linked receptor protein signaling pathway IMP
IMP: 通过突变表型推断
14622576 MGI
acts upstream of or within neuromuscular junction development IDA
IDA: 通过直接分析推断
16794080 MGI
acts upstream of or within neuromuscular junction development IGI
IGI: 通过遗传相互作用推断
16794080 MGI
involved in positive regulation of Rac protein signal transduction IDA
IDA: 通过直接分析推断
16794080 MGI
involved in positive regulation of Rac protein signal transduction IMP
IMP: 通过突变表型推断
16794080 MGI
acts upstream of or within positive regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
16794080 MGI
involved in positive regulation of protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
20603078 MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IDA
IDA: 通过直接分析推断
18848351 MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IGI
IGI: 通过遗传相互作用推断
8653787 MGI
involved in positive regulation of skeletal muscle acetylcholine-gated channel clustering IMP
IMP: 通过突变表型推断
14622576 MGI
acts upstream of protein phosphorylation IMP
IMP: 通过突变表型推断
16794080 MGI
acts upstream of or within receptor clustering IDA
IDA: 通过直接分析推断
16794080 MGI
acts upstream of or within receptor clustering IGI
IGI: 通过遗传相互作用推断
16794080 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in neuromuscular junction IDA
IDA: 通过直接分析推断
14622576 MGI
located in neuromuscular junction IDA
IDA: 通过直接分析推断
16794080 MGI
is active in postsynaptic membrane IDA
IDA: 通过直接分析推断
16794080 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

protein Dok-7

downstream of tyrosine kinase 7

oncoprotein induced transcript 5

Dok7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Dok7 Q18PE0 Musk Mus musculus Q61006
Pull Down
20371544
种属内
Dok7 Q18PE0 Musk Mus musculus Q61006
ITC
20603078
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03939 DOK7 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dok7 NCBI NCBI:285489
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