1. Gene
  2. OTUD3 - OTU deubiquitinase 3 Gene

OTUD3 - OTU deubiquitinase 3 Gene

中文名称:OTU 去泛素化酶 3

种属: Homo sapiens

同用名: DUBA4

基因 ID: 23252 | 基因类型: protein coding

关于 OTUD3

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:19,882,395-19,912,945 (from NCBI)

This gene has 3 transcripts (splice variants), 211 orthologues and 5 paralogues. Broad expression in testis (RPKM 8.1), endometrium (RPKM 3.2) and 23 other tissues.

功能概要

启用硫醇依赖性去泛素化酶。在蛋白激酶 B 信号的负调控上游或负调控中起作用;蛋白质去泛素化;和蛋白质稳定。位于细胞质中。 [由基因组资源联盟提供,2022 年 4 月]

Enables thiol-dependent Deubiquitinase. Acts upstream of or within negative regulation of protein kinase B signaling; protein deubiquitination; and protein stabilization. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

OTUD3 基因产物(1)

mRNA Protein Name
NM_015207.2 NP_056022.1 OTU domain-containing protein 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-type deubiquitinase activity IDA
IDA: 通过直接分析推断
23827681 GOA
enables cysteine-type deubiquitinase activity IMP
IMP: 通过突变表型推断
26280536 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
26280536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to nutrient levels IDA
IDA: 通过直接分析推断
35675826 GOA
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
26280536 GOA
acts upstream of or within negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
26280536 GOA
acts upstream of or within protein K11-linked deubiquitination IDA
IDA: 通过直接分析推断
26280536 GOA
involved in protein K11-linked deubiquitination IDA
IDA: 通过直接分析推断
23827681 GOA
acts upstream of or within protein K27-linked deubiquitination IDA
IDA: 通过直接分析推断
26280536 GOA
acts upstream of or within protein K48-linked deubiquitination IDA
IDA: 通过直接分析推断
26280536 GOA
involved in protein K48-linked deubiquitination IDA
IDA: 通过直接分析推断
35675826 GOA
acts upstream of or within protein K6-linked deubiquitination IDA
IDA: 通过直接分析推断
26280536 GOA
involved in protein K6-linked deubiquitination IDA
IDA: 通过直接分析推断
23827681 GOA
involved in protein deubiquitination IDA
IDA: 通过直接分析推断
32011234 GOA
acts upstream of or within protein stabilization IDA
IDA: 通过直接分析推断
26280536 GOA
involved in protein stabilization IDA
IDA: 通过直接分析推断
35675826 GOA
acts upstream of or within protein stabilization IMP
IMP: 通过突变表型推断
26280536 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
26280536 GOA
is active in nucleus IDA
IDA: 通过直接分析推断
35675826 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

OTUD3 蛋白结构

OTU

OTU: OTU-like cysteine protease (71 - 182)

  • 0
  • 100
  • 200
  • 300
  • 398 a.a.
蛋白主名 其他名称

OTU domain-containing protein 3

OTU domain containing 3

OTUD3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
OTUD3 Q5T2D3 PTEN Homo sapiens P60484-1
Anti Tag CoIP
26280536
种属内
OTUD3 Q5T2D3 PTEN Homo sapiens P60484-1
Pull Down
26280536
种属内
OTUD3 Q5T2D3 HSD17B14 Homo sapiens Q9BPX1
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus OTUD3 RGD RGD:1560468
Macaca mulatta OTUD3 VGNC VGNC:100022
Felis catus OTUD3 VGNC VGNC:80296
Mus musculus OTUD3 MGD MGI:1920412
Canis familiaris OTUD3 VGNC VGNC:44185
Bos taurus OTUD3 VGNC VGNC:32494
Others OTUD3 NCBI