CLASP1 - cytoplasmic linker associated protein 1 Gene

中文名称：细胞质接头相关蛋白 1

种属: Homo sapiens

同用名: MAST1

基因 ID: 23332 | 基因类型: protein coding

关于 CLASP1

Cytogenetic location: 2q14.2-q14.3 Genomic coordinates (GRCh38): 2:121,337,776-121,649,462 (from NCBI)

This gene has 17 transcripts (splice variants), 293 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 7.9), testis (RPKM 6.1) and 25 other tissues.

功能概要

CLASP，例如 CLASP1，是与 CLIP 相互作用的非运动微管相关蛋白 (例如，CLIP170；MIM 179838) 。 CLASP1 参与调节着丝粒和整个纺锤体的微管动力学 (Maiato 等人，2003 [PubMed 12837247]) 。[OMIM 提供，2008 年 3 月]

CLASPs, such as CLASP1, are nonmotor microtubule-associated proteins that interact with CLIPs (e.g., CLIP170; MIM 179838). CLASP1 is involved in the regulation of microtubule dynamics at the kinetochore and throughout the spindle (Maiato et al., 2003 [PubMed 12837247]).[supplied by OMIM, Mar 2008]

CLASP1 基因产物(8)

mRNA	Protein	Name
NM_001142273.2	NP_001135745.1	CLIP-associating protein 1 isoform 2
NM_001142274.2	NP_001135746.1	CLIP-associating protein 1 isoform 3
NM_001207051.2	NP_001193980.1	CLIP-associating protein 1 isoform 4
NM_001378003.1	NP_001364932.1	CLIP-associating protein 1 isoform 5
NM_001378004.1	NP_001364933.1	CLIP-associating protein 1 isoform 6
NM_001378005.1	NP_001364934.1	CLIP-associating protein 1 isoform 7
NM_001395891.1	NP_001382820.1	CLIP-associating protein 1 isoform 8
NM_015282.3	NP_056097.1	CLIP-associating protein 1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables dystroglycan binding	IPI IPI: 通过物理相互作用推断	23940118	GOA
enables kinetochore binding	IMP IMP: 通过突变表型推断	12837247	GOA
enables microtubule binding	IDA IDA: 通过直接分析推断	11290329	GOA
enables microtubule binding	IMP IMP: 通过突变表型推断	12837247	GOA
enables microtubule plus-end binding	IDA IDA: 通过直接分析推断	12837247	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11290329	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Golgi organization	IMP IMP: 通过突变表型推断	24859005	GOA
involved in astral microtubule organization	IMP IMP: 通过突变表型推断	23783028	GOA
acts upstream of or within cell division	IDA IDA: 通过直接分析推断	21822276	GOA
involved in establishment of mitotic spindle localization	IMP IMP: 通过突变表型推断	23783028	GOA
acts upstream of or within establishment of spindle orientation	IDA IDA: 通过直接分析推断	21822276	GOA
acts upstream of or within establishment of spindle orientation	IGI IGI: 通过遗传相互作用推断	21822276	GOA
acts upstream of or within establishment of spindle orientation	IMP IMP: 通过突变表型推断	21822276	GOA
involved in exit from mitosis	IMP IMP: 通过突变表型推断	16866869	GOA
involved in microtubule anchoring	IMP IMP: 通过突变表型推断	17543864	GOA
involved in microtubule bundle formation	IMP IMP: 通过突变表型推断	12837247	GOA
involved in microtubule cytoskeleton organization	IGI IGI: 通过遗传相互作用推断	15631994	GOA
involved in microtubule cytoskeleton organization	IMP IMP: 通过突变表型推断	24859005	GOA
involved in microtubule nucleation	IMP IMP: 通过突变表型推断	17543864	GOA
involved in microtubule organizing center organization	IMP IMP: 通过突变表型推断	17543864	GOA
involved in mitotic spindle organization	IMP IMP: 通过突变表型推断	16866869	GOA
involved in negative regulation of microtubule depolymerization	IGI IGI: 通过遗传相互作用推断	15631994	GOA
involved in negative regulation of microtubule depolymerization	IMP IMP: 通过突变表型推断	16866869	GOA
involved in negative regulation of microtubule polymerization or depolymerization	IMP IMP: 通过突变表型推断	12837247	GOA
involved in negative regulation of stress fiber assembly	IMP IMP: 通过突变表型推断	24859005	GOA
involved in negative regulation of wound healing, spreading of epidermal cells	IMP IMP: 通过突变表型推断	24859005	GOA
involved in positive regulation of basement membrane assembly involved in embryonic body morphogenesis	IGI IGI: 通过遗传相互作用推断	23940118	GOA
involved in positive regulation of basement membrane assembly involved in embryonic body morphogenesis	IMP IMP: 通过突变表型推断	23940118	GOA
involved in positive regulation of epithelial cell migration	IMP IMP: 通过突变表型推断	24859005	GOA
involved in positive regulation of exocytosis	IMP IMP: 通过突变表型推断	24859005	GOA
involved in positive regulation of extracellular matrix disassembly	IMP IMP: 通过突变表型推断	24859005	GOA
involved in regulation of epithelial to mesenchymal transition	IMP IMP: 通过突变表型推断	23940118	GOA
involved in regulation of focal adhesion assembly	IMP IMP: 通过突变表型推断	24859005	GOA
involved in regulation of gastrulation	IMP IMP: 通过突变表型推断	23940118	GOA
involved in regulation of microtubule cytoskeleton organization	IGI IGI: 通过遗传相互作用推断	23940118	GOA
involved in vesicle targeting	IMP IMP: 通过突变表型推断	24859005	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in Golgi apparatus	IDA IDA: 通过直接分析推断	15631994	GOA
located in basal cortex	IDA IDA: 通过直接分析推断	23940118	GOA
located in cell cortex	IDA IDA: 通过直接分析推断	17113391	GOA
located in centrosomal corona	IDA IDA: 通过直接分析推断	16914514	GOA
located in centrosome	IDA IDA: 通过直接分析推断	12837247	GOA
located in cortical microtubule cytoskeleton	IDA IDA: 通过直接分析推断	12837247	GOA
located in cytoplasmic microtubule	IDA IDA: 通过直接分析推断	11290329	GOA
colocalizes with focal adhesion	IDA IDA: 通过直接分析推断	24859005	GOA
located in kinetochore	IDA IDA: 通过直接分析推断	12837247	GOA
located in spindle microtubule	IDA IDA: 通过直接分析推断	12837247	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CLASP1 蛋白结构

CLASP_N

0
300
600
900
1200
1538 a.a.

蛋白主名

其他名称

CLIP-associating protein 1

multiple asters 1

CLASP1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CLASP1	Q7Z460	YWHAE	Homo sapiens	P62258	Anti Tag CoIP	35271311
种属内	CLASP1	Q7Z460	YWHAE	Homo sapiens	P62258	Crosslink	36931259
种属内	CLASP1	Q7Z460	SPAG5	Homo sapiens	Q96R06	Anti Bait CoIP	20852589
种属内	CLASP1	Q7Z460	SPAG5	Homo sapiens	Q96R06	Anti Tag CoIP	20852589
种属内	CLASP1	Q7Z460	KIF1B	Homo sapiens	O60333	Anti Tag CoIP	20852589
种属内	CLASP1	Q7Z460	KIF1B	Homo sapiens	O60333	Anti Bait CoIP	20852589
种属间	CLASP1	Q7Z460	Clip2	Rattus norvegicus	O55156	Anti Tag CoIP	11290329
种属间	CLASP1	Q7Z460	Clip2	Rattus norvegicus	O55156	Pull Down	11290329
种属间	CLASP1	Q7Z460	Clip1	Rattus norvegicus	Q9JK25	Anti Tag CoIP	11290329

种属间: 跨种属相互作用 种属内: 同种属相互作用

CLASP1 抗体

目录号	产品名	应用	反应物种
HY-P82388	CLASP1 Antibody (YA2133)	WB, IHC-P, ICC/IF, FC	Mouse, Rat, Human

关联疾病

疾病名称

别名

Microcephalic Osteodysplastic Primordial Dwarfism, Type I

Taybi-Linder Syndrome	Brachymelic Primordial Dwarfism
Cephaloskeletal Dysplasia	Low-Birth-Weight Dwarfism With Skeletal Dysplasia
Microcephalic Osteodysplastic Primordial Dwarfism Type I	Osteodysplastic Primordial Dwarfism Type I
Primordial Microcephalic Dwarfism, Crachami Type	Osteodysplastic Primordial Dwarfism, Type 1
MOPD1	Mopd I
Mopd	Osteodysplastic Primordial Dwarfism, Type I
Tals	Microcephalic Osteodysplastic Primordial Dwarfism Type 1
Mopd 1	Microcephalic Osteodysplastic Primordial Dwarfism Types 1 And 3
Microcephalic Osteodysplastic Primordial Dwarfism Types I And Iii	Mopd Types I And Iii
Microcephalic Osteodysplastic Primordial Dwarfism, Taybi-Linder Type	Primordial Microcephalic Dwarfism Crachami Type
Dwarfism, Primordial, Osteodysplastic, Microcephalic, Type 1

Lowry-Wood Syndrome

LWS	Epiphyseal Dysplasia, Multiple, With Microcephaly And Retinal Dystrophy
Lowry Wood Syndrome	Epiphyseal Dysplasia, Microcephaly And Nystagmus
Epiphyseal Dysplasia-Microcephaly-Nystagmus Syndrome	Dysplasia, Epiphyseal, Microcephaly, Nystagmus

Spondyloepiphyseal Dysplasia Congenita

SEDC	Sed Congenita
Spondyloepiphyseal Dysplasia, Congenital Type	Late Spondyloepiphyseal Dysplasia
Sed, Congenital Type	Congenital Spondyloepiphyseal Dysplasia
Spranger-Wiedemann Disease	Spondyloepiphyseal Dysplasia Congenital Type
Dysplasia, Spondyloepiphyseal, Congenita	Spondyloepiphyseal Dysplasia, Congenita
Spondyloepiphyseal Dysplasia Tarda, X-Linked

Roifman Syndrome

RFMN	Spondyloepiphyseal Dysplasia, Retinal Dystrophy, And Antibody Deficiency
Spondyloepiphseal Dysplasia, Retinal Dystrophy And Antibody Deficiency	Spondyloepiphyseal Dysplasia-Retinal Dystrophy-Immunodeficiency Syndrome

Balantidiasis

Balantidiosis	Human Balantidiasis
B Coli Infection	Balantidium Coli Infection
Large-Intestinal Infection With Balantidium Coli	Ciliary Dysentery

Theileriasis

Theileriosis

Infection By Theileria

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02744	CLASP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	CLASP1	VGNC	VGNC:27389
Canis familiaris	CLASP1	VGNC	VGNC:39294
Mus musculus	CLASP1	MGD	MGI:1923957
Macaca mulatta	CLASP1	VGNC	VGNC:71193
Rattus norvegicus	CLASP1	RGD	RGD:1310970
Felis catus	CLASP1	VGNC	VGNC:60916

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