2. Gene
  3. Gck - glucokinase Gene

Gck - glucokinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：葡萄糖激酶

种属: Rattus norvegicus

同用名: GLK; GLUKA; RNGK2

基因 ID: 24385 | 基因类型: protein coding

关于 Gck

Primary_assembly 14: 80,785,060-80,826,995 reverse strand.mRatBN7.2:CM026987.1

This gene has 4 transcripts (splice variants), 214 orthologues, 4 paralogues and is associated with 29 phenotypes. Biased expression in Liver (RPKM 79.4) and Heart (RPKM 6.).

功能概要

该基因编码的蛋白可启动多种功能，包括腺苷酸核糖核苷酸结合活性；葡萄糖结合活性；和己糖激酶活性。涉及多个过程，包括细胞化学稳态；细胞对激素刺激的反应；和己糖代谢过程。位于多个细胞成分中，包括基底皮层；核质；和分泌颗粒。与肌动蛋白丝共定位。用于研究脂肪肝；肥胖;和 2 型糖尿病。该基因的人类直系同源物与动脉疾病有关（多个）；家族性高胰岛素血症性低血糖 3；和糖代谢疾病（多种）。与人 GCK（葡萄糖激酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including adenyl ribonucleotide binding activity; glucose binding activity; and Hexokinase activity. Involved in several processes, including cellular chemical homeostasis; cellular response to hormone stimulus; and hexose metabolic process. Located in several cellular components, including basal cortex; nucleoplasm; and secretory granule. Colocalizes with actin filament. Used to study fatty liver disease; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in artery disease (multiple); familial hyperinsulinemic hypoglycemia 3; and glucose metabolism disease (multiple). Orthologous to human GCK (Glucokinase). [provided by Alliance of Genome Resources, Apr 2022]

Gck 基因产物(3)

mRNA Protein Name
NM_001270849.1 NP_001257778.1 hexokinase-4 isoform 1
NM_001270850.1 NP_001257779.1 hexokinase-4 isoform 3
NM_012565.2 NP_036697.1 hexokinase-4 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ADP binding IDA
IDA: 通过直接分析推断
12513690 RGD
enables ATP binding IDA
IDA: 通过直接分析推断
12513690 RGD
enables D-glucose binding IDA
IDA: 通过直接分析推断
4273555 RGD
enables D-glucose binding IPI
IPI: 通过物理相互作用推断
12513690 RGD
enables fructokinase activity IDA
IDA: 通过直接分析推断
6477520 RGD
enables glucokinase activity IDA
IDA: 通过直接分析推断
4273555 RGD
enables glucose sensor activity IDA
IDA: 通过直接分析推断
17470517 RGD
enables magnesium ion binding IDA
IDA: 通过直接分析推断
12513690 RGD
enables mannokinase activity IDA
IDA: 通过直接分析推断
7742312 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
10601273 RGD
enables protein phosphatase binding IPI
IPI: 通过物理相互作用推断
10913113 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in carbohydrate phosphorylation IDA
IDA: 通过直接分析推断
9109397 RGD
involved in cellular response to glucose starvation IMP
IMP: 通过突变表型推断
18292346 RGD
involved in cellular response to insulin stimulus IDA
IDA: 通过直接分析推断
17470517 RGD
involved in cellular response to leptin stimulus IDA
IDA: 通过直接分析推断
17470517 RGD
involved in fructose 2,6-bisphosphate metabolic process IDA
IDA: 通过直接分析推断
17553851 RGD
involved in fructose 6-phosphate metabolic process IDA
IDA: 通过直接分析推断
6477520 RGD
involved in glucose 6-phosphate metabolic process IDA
IDA: 通过直接分析推断
4273555 RGD
involved in glucose metabolic process IDA
IDA: 通过直接分析推断
17553851 RGD
involved in glycogen biosynthetic process IDA
IDA: 通过直接分析推断
17028192 RGD
involved in glycolytic process IDA
IDA: 通过直接分析推断
4273555 RGD
involved in intracellular glucose homeostasis IMP
IMP: 通过突变表型推断
16443775 RGD
involved in lipid homeostasis IDA
IDA: 通过直接分析推断
22925001 RGD
involved in mannose metabolic process IDA
IDA: 通过直接分析推断
7742312 RGD
involved in negative regulation of epinephrine secretion IMP
IMP: 通过突变表型推断
18292346 RGD
involved in positive regulation of cytosolic calcium ion concentration IDA
IDA: 通过直接分析推断
17360975 RGD
involved in positive regulation of glycolytic process IDA
IDA: 通过直接分析推断
17553851 RGD
involved in positive regulation of insulin secretion IDA
IDA: 通过直接分析推断
17028192 RGD
involved in positive regulation of phosphorylation IDA
IDA: 通过直接分析推断
17553851 RGD
involved in regulation of glucose mediated signaling pathway IMP
IMP: 通过突变表型推断
16443775 RGD
involved in response to glucose IDA
IDA: 通过直接分析推断
17470517 RGD
involved in response to glucose IEP
IEP: 通过表达模式推断
12086933 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in actin filament IDA
IDA: 通过直接分析推断
9109397 RGD
located in basal cortex IDA
IDA: 通过直接分析推断
10071239 RGD
located in cell cortex IDA
IDA: 通过直接分析推断
12369705 RGD
located in cytoplasm IDA
IDA: 通过直接分析推断
10601273 RGD
located in nucleoplasm IDA
IDA: 通过直接分析推断
12369705 RGD
located in nucleus IDA
IDA: 通过直接分析推断
10601273 RGD
located in secretory granule IDA
IDA: 通过直接分析推断
9357983 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Gck 蛋白结构

Hexokinase_1

Hexokinase_1: pfam00349 (99 - 247)

Hexokinase_2

Hexokinase_2: pfam03727 (253 - 487)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 498 a.a.
蛋白主名 其他名称

hexokinase-4

HK IV

HK4

hexokinase type IV

hexokinase-D

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-147141 HS-276 Inhibitor 98.59% 否
HY-15489 Scriptaid 98.59% 否
HY-10943 GNF-7 Inhibitor 99.70% 否
HY-123714 TL4-12 99.82% 否
HY-RS05329 GCK Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05330 Gck Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS05331 Gck Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Gck NCBI NCBI:2645
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