Pkd1 - polycystin 1, transient receptor potential channel interacting Gene

中文名称：多囊蛋白 1 ，瞬时受体电位通道相互作用

种属: Rattus norvegicus

关于 Pkd1

功能概要

预计该基因编码的蛋白具有多种功能，包括 Wnt 激活受体活性；蛋白激酶结合活性；和跨膜转运蛋白结合活性。预计有助于钙通道活动。参与细胞溶质钙离子浓度的正向调节。位于高尔基体和外侧质膜。用于研究多囊肾病。该基因的人类直系同源物与常染色体显性多囊肾病有关；颅内动脉瘤;和多囊肾病 1. 与人类 PKD1（多囊蛋白 1，瞬时受体电位通道相互作用）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including Wnt-activated receptor activity; protein kinase binding activity; and transmembrane transporter binding activity. Predicted to contribute to Calcium Channel activity. Involved in positive regulation of cytosolic calcium ion concentration. Located in Golgi apparatus and lateral plasma membrane. Used to study polycystic kidney disease. Human ortholog(s) of this gene implicated in autosomal dominant polycystic kidney disease; intracranial aneurysm; and polycystic kidney disease 1. Orthologous to human PKD1 (polycystin 1, transient receptor potential channel interacting). [provided by Alliance of Genome Resources, Apr 2022]