2. Gene
  3. Vdr - vitamin D receptor Gene

Vdr - vitamin D receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：维生素 D 受体

种属: Rattus norvegicus

同用名: Nr1i1

基因 ID: 24873 | 基因类型: protein coding

关于 Vdr

Primary_assembly 7: 128,987,981-129,037,677 reverse strand.mRatBN7.2:CM026980.1

This gene has 1 transcript (splice variant), 462 orthologues, 19 paralogues and is associated with 109 phenotypes. Biased expression in Kidney (RPKM 182.4), Lung (RPKM 16.2) and 3 other tissues.

功能概要

该基因编码的蛋白可启动骨化三醇结合活动；核受体活性；和序列特异性 DNA 结合活性。参与多个过程，包括对淀粉样蛋白-β 的细胞反应；骨小梁形成的负调节；及甲状旁腺激素分泌的正调节作用。位于多个细胞成分中，包括 T 管；染色质；和核腔。与小窝共定位。用于研究 2A 型维生素 D 依赖性佝偻病。继发性甲状旁腺功能亢进症的生物标志物。该基因的人类直系同源物与多种疾病有关，包括自身免疫性疾病（多种）；癌（多发性）；脂质贮积症（多种）；黑色素瘤（多发性）；和肺结核（多发）。与人类 VDR（维生素 D 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables calcitriol binding activity; nuclear receptor activity; and sequence-specific DNA binding activity. Involved in several processes, including cellular response to amyloid-beta; negative regulation of bone trabecula formation; and positive regulation of parathyroid hormone secretion. Located in several cellular components, including T-tubule; chromatin; and nuclear lumen. Colocalizes with caveola. Used to study vitamin D-dependent rickets type 2A. Biomarker of secondary hyperparathyroidism. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); lipid storage disease (multiple); melanoma (multiple); and tuberculosis (multiple). Orthologous to human VDR (vitamin D receptor). [provided by Alliance of Genome Resources, Apr 2022]

Vdr 基因产物(1)

mRNA Protein Name
NM_017058.2 NP_058754.2 vitamin D3 receptor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcitriol binding IDA
IDA: 通过直接分析推断
8179318 RGD
enables nuclear receptor activity IDA
IDA: 通过直接分析推断
9579411 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
19074549 RGD
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
16481392 RGD
enables vitamin D binding IDA
IDA: 通过直接分析推断
2829212 RGD
enables vitamin D binding IMP
IMP: 通过突变表型推断
2829212 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in apoptotic signaling pathway IDA
IDA: 通过直接分析推断
9579411 RGD
involved in cellular response to amyloid-beta IEP
IEP: 通过表达模式推断
23752060 RGD
involved in cellular response to vitamin D IEP
IEP: 通过表达模式推断
9753201 RGD
involved in heart development IEP
IEP: 通过表达模式推断
12107506 RGD
involved in negative regulation of bone trabecula formation IMP
IMP: 通过突变表型推断
32231239 RGD
involved in negative regulation of ossification IMP
IMP: 通过突变表型推断
32231239 RGD
involved in positive regulation of parathyroid hormone secretion IMP
IMP: 通过突变表型推断
32231239 RGD
involved in regulation of calcium ion transport IDA
IDA: 通过直接分析推断
18353900 RGD
involved in response to aldosterone IEP
IEP: 通过表达模式推断
29713904 RGD
involved in response to calcium ion IEP
IEP: 通过表达模式推断
20181667 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
10724336 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in T-tubule IDA
IDA: 通过直接分析推断
20015453 RGD
located in caveola IDA
IDA: 通过直接分析推断
15272054 RGD
located in dense fibrillar component IDA
IDA: 通过直接分析推断
8392883 RGD
located in euchromatin IDA
IDA: 通过直接分析推断
8392883 RGD
located in heterochromatin IDA
IDA: 通过直接分析推断
8392883 RGD
located in nuclear matrix IDA
IDA: 通过直接分析推断
9744521 RGD
located in perinuclear region of cytoplasm IDA
IDA: 通过直接分析推断
9220147 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Vdr 蛋白结构

NR_DBD_VDR

NR_DBD_VDR: cd06955 (15 - 121)

NR_LBD_VDR

NR_LBD_VDR: cd06933 (123 - 421)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 423 a.a.
蛋白主名 其他名称

vitamin D3 receptor

1,25-dihydroxyvitamin D3 receptor

nuclear receptor subfamily 1 group I member 1

vitamin D (1,25- dihydroxyvitamin D3) receptor

相关产品

Approval
生物活性分子 (5)
目录号 产品名 作用方式
纯度 是否罕见病
HY-10002 Calcitriol Agonist 99.94% 否
HY-32351 Calcifediol 99.94% 否
HY-10003 Alfacalcidol Activator 99.96% 否
HY-32339 Maxacalcitol Activator 99.71% 否
HY-32351A Calcifediol monohydrate 99.89% 否
Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-32344 Inecalcitol 97.42% Phase 2
HY-14863 Lunacalcipol / Phase 2
HY-B1844 Flucythrinate / Phase 1
Pre-clinical Phase
生物活性分子 (41)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-147337 MeTC7 Antagonist 98.50% 否
HY-32343 Secalciferol Activator 99.89% 否
HY-12398 TEI-9647 Agonist 99.88% 否
HY-12407 ZK168281 Antagonist ≥98.0% 否
HY-76814 Calcitriol-d6 Activator 99.06% 否
HY-12398A TEI-9648 Inhibitor 99.30% 否
HY-12397 ZK159222 Antagonist 98.27% 否
HY-13332 Calcifediol-d6 Activator 98.91% 否
HY-103053 PS121912 Inhibitor ≥95.0% 否
HY-15329 Maxacalcitol-d6 Activator 99.63% 否
HY-10002A (1S)-Calcitriol 98.94% 否
HY-32351S Calcifediol-d3 99.06% 否
HY-15332 Alfacalcidol-d6 Activator ≥98.0% 否
HY-15265 Impurity F of Calcipotriol Activator 97.64% 否
HY-RS15632 VDR Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-13294 Impurity C of Alfacalcidol Activator 99.81% 否
HY-13292 Impurity B of Calcitriol Activator 98.04% 否
HY-13293 Impurity C of Calcitriol Activator 99.84% 否
HY-75035 Calcipotriol Impurity C Activator 99.20% 否
HY-77278 25-Hydroxytachysterol3 Agonist 98.89% 否
HY-32345 Elocalcitol Agonist 99.2% 否
HY-131961 Triciferol 98.61% 否
HY-15266 24R-Calcipotriol Activator / 否
HY-75041 Calcitriol Impurities A Activator 99.78% 否
HY-77274 Calcitriol Impurities D Activator 95.18% 否
HY-15264 MC 1046 Activator 91.48% 否
HY-114310 VDR agonist 1 / 否
HY-10002S1 Calcitriol-d3 / 否
HY-10003S Alfacalcidol-d7 Activator / 否
HY-117182 LG190178 / 否
HY-149899 VDR agonist 2 Agonist / 否
HY-161778 ZG-126 / 否
HY-163947 UG-480 Modulator / 否
HY-32351AS Calcifediol-d6 monohydrate / 否
HY-32351AS1 Calcifediol-13C5 monohydrate / 否
HY-RS15633 Vdr Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS15634 Vdr Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-10002S Calcitriol-13C3 Inhibitor ≥97.0% 否
HY-119586 LG190119 Modulator / 否
HY-N10508 Calcitroic acid Agonist / 否
HY-107218 11-Hydroxysugiol Modulator / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Vdr NCBI NCBI:7421
Mus musculus Vdr NCBI NCBI:22337
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z