2. Gene
  3. Bcl2l1 - Bcl2-like 1 Gene

Bcl2l1 - Bcl2-like 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：Bcl2 样1

种属: Rattus norvegicus

同用名: Bclx; Bcl2l; bcl-X; Bcl-xl

基因 ID: 24888 | 基因类型: protein coding

关于 Bcl2l1

Primary_assembly 3: 141,253,523-141,303,479 reverse strand.mRatBN7.2:CM026976.1

This gene has 3 transcripts (splice variants), 183 orthologues, 13 paralogues and is associated with 65 phenotypes. Biased expression in Thymus (RPKM 183.6), Kidney (RPKM 139.6) and 9 other tissues.

功能概要

该基因编码的蛋白可启动多项功能，包括 GTPase 绑定活动； MDM2/MDM4 家族蛋白结合活性；和参与细胞凋亡过程的半胱氨酸型内肽酶抑制剂活性。参与多个过程，包括细胞对细胞因子刺激的反应；细胞对脂质的反应；和运输的积极监管。位于胞质溶胶中；线粒体外膜；和突触前。与网格蛋白涂层坑共定位；线粒体膜；和突触小泡膜。用于研究肌萎缩侧索硬化；动脉疾病（多发性）；子宫内膜异位症;胃溃疡;和阳痿。多种疾病的生物标志物，包括急性肾功能衰竭；脑缺血;精神抑郁症；高眼压症;和癫痫持续状态。该基因与乳腺癌相关的人类直向同源基因；癌（多发性）；白血病（多发性）；胰腺癌;和胃癌。与人类 BCL2L1 同源（BCL2 like 1）。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including GTPase binding activity; MDM2/MDM4 family protein binding activity; and cysteine-type endopeptidase inhibitor activity involved in apoptotic process. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and positive regulation of transport. Located in cytosol; mitochondrial outer membrane; and presynapse. Colocalizes with clathrin-coated pit; mitochondrial membrane; and synaptic vesicle membrane. Used to study amyotrophic lateral sclerosis; artery disease (multiple); endometriosis; gastric ulcer; and impotence. Biomarker of several diseases, including acute kidney failure; brain ischemia; mental depression; ocular hypertension; and status epilepticus. Human ortholog(s) of this gene implicated in breast cancer; carcinoma (multiple); leukemia (multiple); pancreatic cancer; and stomach Cancer. Orthologous to human BCL2L1 (BCL2 like 1). [provided by Alliance of Genome Resources, Apr 2022]

Bcl2l1 基因产物(4)

mRNA Protein Name
NM_031535.2 NP_113723.2 bcl-2-like protein 1 isoform 1
NM_001033671.1 NP_001028843.1 bcl-2-like protein 1 isoform 3
NM_001033670.1 NP_001028842.1 bcl-2-like protein 1 isoform 2
NM_001033672.1 NP_001028844.1 bcl-2-like protein 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables BH domain binding IPI
IPI: 通过物理相互作用推断
9356461 RGD
enables GTPase binding IPI
IPI: 通过物理相互作用推断
23792689 RGD
enables MDM2/MDM4 family protein binding IPI
IPI: 通过物理相互作用推断
17060322 RGD
enables clathrin binding IPI
IPI: 通过物理相互作用推断
23792689 RGD
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
IDA: 通过直接分析推断
12097494 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
9731710 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
9356461 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to astaxanthin IEP
IEP: 通过表达模式推断
22889354 RGD
involved in cellular response to cAMP IEP
IEP: 通过表达模式推断
22158476 RGD
involved in cellular response to dexamethasone stimulus IEP
IEP: 通过表达模式推断
12904174 RGD
involved in cellular response to erythropoietin IEP
IEP: 通过表达模式推断
22293409 RGD
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
20669351 RGD
involved in cellular response to interleukin-1 IEP
IEP: 通过表达模式推断
20798690 RGD
involved in cellular response to nitric oxide IEP
IEP: 通过表达模式推断
25726415 RGD
involved in cellular response to prolactin IEP
IEP: 通过表达模式推断
12904174 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: 通过表达模式推断
21937453 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
18483861 RGD
involved in cerebral cortex development IEP
IEP: 通过表达模式推断
9813151 RGD
involved in negative regulation of apoptotic process IDA
IDA: 通过直接分析推断
12097494 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
22382519 RGD
involved in ovarian follicle development IMP
IMP: 通过突变表型推断
17989359 RGD
involved in positive regulation of ATP biosynthetic process IMP
IMP: 通过突变表型推断
23792689 RGD
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
22158476 RGD
involved in positive regulation of synaptic vesicle clustering IMP
IMP: 通过突变表型推断
23792689 RGD
involved in positive regulation of synaptic vesicle endocytosis IMP
IMP: 通过突变表型推断
23792689 RGD
involved in positive regulation of synaptic vesicle exocytosis IMP
IMP: 通过突变表型推断
23792689 RGD
involved in regulation of apoptotic process IDA
IDA: 通过直接分析推断
12515824 RGD
involved in regulation of long-term synaptic depression IMP
IMP: 通过突变表型推断
23792689 RGD
involved in regulation of synaptic vesicle endocytosis IDA
IDA: 通过直接分析推断
23792689 RGD
involved in regulation of synaptic vesicle endocytosis IEP
IEP: 通过表达模式推断
23792689 RGD
involved in regulation of synaptic vesicle endocytosis IMP
IMP: 通过突变表型推断
23792689 RGD
involved in response to electrical stimulus IEP
IEP: 通过表达模式推断
17700647 RGD
involved in response to endoplasmic reticulum stress IEP
IEP: 通过表达模式推断
20798690 RGD
involved in response to erythropoietin IEP
IEP: 通过表达模式推断
18838949 RGD
involved in response to hydrogen peroxide IEP
IEP: 通过表达模式推断
17869087 RGD
involved in response to hypoxia IEP
IEP: 通过表达模式推断
17272823 RGD
involved in response to ischemia IDA
IDA: 通过直接分析推断
21410437 RGD
involved in response to lead ion IEP
IEP: 通过表达模式推断
17912701 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
18838949 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
17805306 RGD
involved in response to oxidative stress IEP
IEP: 通过表达模式推断
12721309 RGD
involved in response to peptide hormone IEP
IEP: 通过表达模式推断
17728251 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
11931842 RGD
involved in synaptic vesicle recycling via endosome IMP
IMP: 通过突变表型推断
23792689 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in clathrin-coated pit IDA
IDA: 通过直接分析推断
23792689 RGD
located in mitochondrial membrane IDA
IDA: 通过直接分析推断
23792689 RGD
located in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
12515824 RGD
located in presynapse IDA
IDA: 通过直接分析推断
23792689 RGD
is active in synaptic vesicle IDA
IDA: 通过直接分析推断
23792689 RGD
located in synaptic vesicle membrane IDA
IDA: 通过直接分析推断
23792689 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Bcl2l1 蛋白结构

bcl-2

bcl-2: TIGR00865 (0 - 187)

  • 0
  • 100
  • 200
  • 284 a.a.
蛋白主名 其他名称

bcl-2-like protein 1

B cell lymphoma 2 like

B cell lymphoma like X

apoptosis regulator Bcl-X

bcl2-L-1

相关产品

Clinical Phase
生物活性分子 (5)
目录号 产品名 作用方式
纯度 Phase
HY-10969 Obatoclax Mesylate 99.85% Phase 3
HY-15464A (R)-(-)-Gossypol acetic acid 98.93% Phase 3
HY-N0867 13-Oxyingenol-13-dodecanoate 99.37% Phase 3
HY-10969A Obatoclax ≥99.0% Phase 3
HY-15464 (R)-(-)-Gossypol 98.82% Phase 2
Pre-clinical Phase
生物活性分子 (33)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-107738 Guggulsterone 99.95% 否
HY-125876 PROTAC Bcl2 degrader-1 Inhibitor 99.80% 否
HY-P1889 Bim BH3, Peptide IV 99.35% 否
HY-132307 Mcl-1 inhibitor 6 98.40% 否
HY-P2343 BH3 hydrochloride Activator 98.02% 否
HY-15191B (S)-Sabutoclax Inhibitor 98.03% 否
HY-135273 A-1211212 / 否
HY-RS01421 BCL2L1 Human Pre-designed siRNA Set A / 否
HY-114310 VDR agonist 1 / 否
HY-19551 Apogossypolone / 否
HY-118925 Holothurin A Inhibitor / 否
HY-123715 Anticancer agent 255 / 否
HY-144428 Bcl-2/Mcl-1-IN-2 Inhibitor / 否
HY-144430 Bcl-2/Mcl-1-IN-1 Inhibitor / 否
HY-144431 Bcl-2/Mcl-1-IN-3 Inhibitor / 否
HY-147826 EGFR-IN-60 / 否
HY-149436 CDK2/Bcl2-IN-1 Inhibitor / 否
HY-156877 Bcl-2-IN-16 Inhibitor / 否
HY-159513 Bcl-2/Mcl-1-IN-4 Inhibitor / 否
HY-161415 BCL-xL/BCL-2 ligand 1 / 否
HY-169083 Bcl-2-IN-22 Inhibitor / 否
HY-N3828 epi-Eriocalyxin A / 否
HY-P1889A Bim BH3, Peptide IV TFA / 否
HY-RS01418 BCL2A1 Human Pre-designed siRNA Set A / 否
HY-RS01419 Bcl2a1 Rat Pre-designed siRNA Set A / 否
HY-RS01420 Bcl2a1a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01422 Bcl2l1 Mouse Pre-designed siRNA Set A / 否
HY-RS01423 Bcl2l1 Rat Pre-designed siRNA Set A / 否
HY-115529 (-)BI97D6 Inducer / 否
HY-116532 YCW-E11 Inhibitor / 否
HY-12011A (Rac)-HA14-1 Inhibitor / 否
HY-122047 SW063058 / 否
HY-N8579 Eugenyl benzoate / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bcl2l1 NCBI NCBI:598
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