Slc2a4 - solute carrier family 2 member 4 Gene

中文名称：溶质载体家族 2 成员 4

种属: Rattus norvegicus

同用名: Glut4

关于 Slc2a4

功能概要

该基因编码的蛋白可启动 D-葡萄糖跨膜转运蛋白活性。参与多个过程，包括响应胰岛素刺激的葡萄糖输入；突触前内吞区膜突触小泡出芽的调节；和对乙醇的反应。在上游或内部对长期记忆产生积极影响。在上游或内部对短期记忆产生负面影响。在学习或记忆的上游或内部发挥作用，并积极调节脑源性神经营养因子受体信号通路。位于多个细胞成分中，包括 T 管；网格蛋白涂层坑；和细胞质囊泡。在突触前活跃。与囊泡共定位。肺动脉高压的生物标志物。该基因的人类直系同源物与 2 型糖尿病有关。与人类 SLC2A4（溶质载体家族 2 成员 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables D-glucose transmembrane transporter activity. Involved in several processes, including glucose import in response to Insulin stimulus; regulation of synaptic vesicle budding from presynaptic endocytic zone membrane; and response to ethanol. Acts upstream of or within with a positive effect on long-term memory. Acts upstream of or within with a negative effect on short-term memory. Acts upstream of or within learning or memory and positive regulation of brain-derived neurotrophic factor receptor signaling pathway. Located in several cellular components, including T-tubule; clathrin-coated pit; and cytoplasmic vesicle. Is active in presynapse. Colocalizes with vesicle. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human SLC2A4 (solute carrier family 2 member 4). [provided by Alliance of Genome Resources, Apr 2022]