2. Gene
  3. Plk1 - polo-like kinase 1 Gene

Plk1 - polo-like kinase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：马球样激酶 1

种属: Rattus norvegicus

同用名: Plk

基因 ID: 25515 | 基因类型: protein coding

关于 Plk1

Primary_assembly 1: 176,716,420-176,726,400 forward strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 186 orthologues, 4 paralogues and is associated with 10 phenotypes. Biased expression in Thymus (RPKM 13.3), Spleen (RPKM 69.1) and 8 other tissues.

功能概要

预计该基因编码的蛋白可启动多种功能，包括 ATP 绑定活动；后期促进复合物结合活性；和镁离子结合活性。参与减数分裂后的极体挤压和对抗生素的反应。作用于蛋白质磷酸化的上游或内部。位于细胞质中；核;和主轴。该基因的人类直系同源物与膀胱癌有关。与人类 PLK1（马球样激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including ATP binding activity; anaphase-promoting complex binding activity; and magnesium ion binding activity. Involved in polar body extrusion after meiotic divisions and response to Antibiotic. Acts upstream of or within protein phosphorylation. Located in cytoplasm; nucleus; and spindle. Human ortholog(s) of this gene implicated in urinary bladder Cancer. Orthologous to human PLK1 (polo like kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Plk1 基因产物(1)

mRNA Protein Name
NM_017100.2 NP_058796.2 serine/threonine-protein kinase PLK1
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in polar body extrusion after meiotic divisions IMP
IMP: 通过突变表型推断
12784254 RGD
acts upstream of or within protein phosphorylation IGI
IGI: 通过遗传相互作用推断
19638580 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in spindle midzone IDA
IDA: 通过直接分析推断
12784254 RGD
located in spindle pole IDA
IDA: 通过直接分析推断
12784254 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Plk1 蛋白结构

STKc_PLK1

STKc_PLK1: cd14187 (44 - 308)

POLO_box_1

POLO_box_1: cd13118 (406 - 493)

POLO_box_2

POLO_box_2: cd13117 (508 - 589)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 603 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase PLK1

PLK-1

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-12137 Volasertib Inhibitor 99.41% 是
HY-12137A Volasertib trihydrochloride Inhibitor / 否
Clinical Phase
生物活性分子 (9)
目录号 产品名 作用方式
纯度 Phase
HY-12037A Rigosertib Inhibitor 98.52% Phase 3
HY-12037 Rigosertib sodium Inhibitor 99.57% Phase 3
HY-50698 BI 2536 Inhibitor 99.95% Phase 2
HY-15828 Onvansertib Inhibitor 99.55% Phase 2
HY-147298 Plogosertib Inhibitor 99.95% Phase 2
HY-50877 GSK461364 Inhibitor 99.82% Phase 1
HY-15160 TAK-960 Inhibitor 99.75% Phase 1
HY-15160B TAK-960 dihydrochloride Inhibitor 99.19% Phase 1
HY-15160A TAK-960 hydrochloride Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (23)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-100789 ON1231320 Inhibitor 99.24% 否
HY-11003 GW843682X Inhibitor 99.89% 否
HY-18009 (Z)-LFM-A13 Inhibitor 99.80% 否
HY-15161 Ro3280 Inhibitor 98.87% 否
HY-15155 MLN0905 Inhibitor 99.94% 否
HY-108597 TC-S 7005 Inhibitor 99.56% 否
HY-12045 HMN-214 Inhibitor 99.25% 否
HY-15158 SBE13 Hydrochloride Inhibitor 99.66% 否
HY-12134 Poloxin Inhibitor 98.01% 否
HY-N8692 Dihydrobaicalein Inhibitor 99.94% 否
HY-15159 Cyclapolin 9 Inhibitor 99.16% 否
HY-158031 PLK1/BRD4-IN-5 Inhibitor 99.55% 否
HY-160558 PLK1/BRD4-IN-3 Inhibitor 99.66% 否
HY-110002 LFM-A13 Inhibitor 99.65% 否
HY-77195 Poloxime Inhibitor ≥95.0% 否
HY-15158A SBE13 Inhibitor / 否
HY-18651 (E/Z)-Rigosertib sodium / 否
HY-148974 PLK1-IN-5 Inhibitor / 否
HY-115589 YLT-11 Inhibitor / 否
HY-143471 WNY0824 Inhibitor / 否
HY-112395 BTO-1 Inhibitor / 否
HY-149100 PLK1-IN-6 Inhibitor / 否
HY-161521 PLK1-IN-10 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Plk1 NCBI NCBI:5347
Mus musculus Plk1 NCBI NCBI:18817
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