2. Gene
  3. Hspa5 - heat shock protein family A (Hsp70) member 5 Gene

Hspa5 - heat shock protein family A (Hsp70) member 5 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：热休克蛋白家族 A (Hsp70) 成员 5

种属: Rattus norvegicus

同用名: BIP; GRP78; GRP 78

基因 ID: 25617 | 基因类型: protein coding

关于 Hspa5

Primary_assembly 3: 18,055,405-18,059,891 forward strand.mRatBN7.2:CM026976.1

This gene has 1 transcript (splice variant), 257 orthologues, 13 paralogues and is associated with 37 phenotypes. Biased expression in Liver (RPKM 2693.8), Heart (RPKM 215.3) and 9 other tissues.

功能概要

该基因编码的蛋白可启动错误折叠的蛋白质结合活性和未折叠的蛋白质结合活性。参与多个过程，包括对 cAMP 的细胞反应；细胞对伽马辐射的反应；和细胞对金属离子的反应。在内质网应激反应的上游或反应中起作用。位于膜内；线粒体；和光滑的内质网。脂肪肝疾病的生物标志物；创伤后应激障碍；短暂性脑缺血；输尿管梗阻；和视觉性癫痫。该基因的人类直系同源物与多巴胺 β-羟化酶缺乏症有关。与人类 HSPA5（热休克蛋白家族 A (HSP70) 成员 5）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables misfolded protein binding activity and unfolded protein binding activity. Involved in several processes, including cellular response to cAMP; cellular response to gamma radiation; and cellular response to metal ion. Acts upstream of or within response to endoplasmic reticulum stress. Located in membrane; mitochondrion; and smooth endoplasmic reticulum. Biomarker of fatty liver disease; post-traumatic stress disorder; transient cerebral ischemia; ureteral obstruction; and visual epilepsy. Human ortholog(s) of this gene implicated in dopamine beta-hydroxylase deficiency. Orthologous to human HSPA5 (heat shock protein family A (HSP70) member 5). [provided by Alliance of Genome Resources, Apr 2022]

Hspa5 基因产物(1)

mRNA Protein Name
NM_013083.2 NP_037215.1 endoplasmic reticulum chaperone BiP precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables misfolded protein binding IDA
IDA: 通过直接分析推断
23444373 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
7916014 RGD
enables unfolded protein binding IPI
IPI: 通过物理相互作用推断
11884402 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to antibiotic IEP
IEP: 通过表达模式推断
19332540 RGD
involved in cellular response to cAMP IEP
IEP: 通过表达模式推断
9058202 RGD
involved in cellular response to calcium ion IEP
IEP: 通过表达模式推断
9058202 RGD
involved in cellular response to gamma radiation IEP
IEP: 通过表达模式推断
20470193 RGD
involved in cellular response to manganese ion IEP
IEP: 通过表达模式推断
23934647 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: 通过表达模式推断
10936191 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
18757512 RGD
involved in luteolysis IEP
IEP: 通过表达模式推断
25332219 RGD
involved in neuron apoptotic process IEP
IEP: 通过表达模式推断
9058202 RGD
involved in neuron differentiation IEP
IEP: 通过表达模式推断
19322020 RGD
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
10936191 RGD
involved in response to cocaine IEP
IEP: 通过表达模式推断
17849098 RGD
acts upstream of or within response to endoplasmic reticulum stress IDA
IDA: 通过直接分析推断
23444373 RGD
involved in response to endoplasmic reticulum stress IEP
IEP: 通过表达模式推断
22189689 RGD
involved in response to methamphetamine hydrochloride IEP
IEP: 通过表达模式推断
19826936 RGD
involved in stress response to metal ion IEP
IEP: 通过表达模式推断
17915553 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in dendritic shaft IDA
IDA: 通过直接分析推断
26088419 RGD
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
19474315 RGD
located in membrane IDA
IDA: 通过直接分析推断
23444373 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
26088419 RGD
located in smooth endoplasmic reticulum IDA
IDA: 通过直接分析推断
22665516 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Hspa5 蛋白结构

HSP70

HSP70: pfam00012 (29 - 634)

  • 0
  • 200
  • 400
  • 600
  • 654 a.a.
蛋白主名 其他名称

endoplasmic reticulum chaperone BiP

78 kDa glucose-regulated protein

GRP-78

HSP70 family protein 5

binding-immunoglobulin protein

heat shock 70 kDa protein 5

heat shock 70kD protein 5

heat shock 70kDa protein 5 (glucose-regulated protein)

heat shock protein 5

heat shock protein 70 family protein 5

heat shock protein family A member 5

immunoglobulin heavy chain-binding protein

steroidogenesis-activator polypeptide

Hspa5 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Hspa5 P06761 Tg Rattus norvegicus P06882
Density Sedimentation
7916014
种属内
Hspa5 P06761 Sigmar1 Rattus norvegicus Q9R0C9
Pull Down
17981125
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-125974 HM03 Inhibitor 99.34% 否
HY-152153 GRP78-IN-3 Inhibitor 99.98% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hspa5 NCBI NCBI:3309
Mus musculus Hspa5 NCBI NCBI:14828
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