2. Gene
  3. TENM4 - teneurin transmembrane protein 4 Gene

TENM4 - teneurin transmembrane protein 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：teneurin 跨膜蛋白 4

种属: Homo sapiens

同用名: Doc4; ETM5; ODZ4; TEN4; TNM4; ten-4; Ten-M4

基因 ID: 26011 | 基因类型: protein coding

关于 TENM4

Cytogenetic location: 11q14.1 Genomic coordinates (GRCh38): 11:78,652,829-79,441,030 (from NCBI)

This gene has 11 transcripts (splice variants), 204 orthologues, 4 paralogues and is associated with 2 phenotypes. Biased expression in ovary (RPKM 7.7), thyroid (RPKM 3.2) and 8 other tissues.

功能概要

由该基因编码的蛋白质在发育过程中在建立适当的神经元连接方面发挥作用。该基因的缺陷与遗传性原发性震颤 5 相关。[RefSeq 提供，2016 年 10 月]

The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5. [provided by RefSeq, Oct 2016]

TENM4 基因产物(1)

mRNA Protein Name
NM_001098816.3 NP_001092286.2 teneurin-4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in central nervous system myelin formation IMP
IMP: 通过突变表型推断
26188006 GOA
involved in neuron development IMP
IMP: 通过突变表型推断
26188006 GOA
involved in regulation of myelination IMP
IMP: 通过突变表型推断
26188006 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
26188006 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TENM4 蛋白结构

Ten_N

Ten_N: Teneurin Intracellular Region (10 - 167)

Ten_N

Ten_N: Teneurin Intracellular Region (165 - 340)

EGF_2

EGF_2: EGF-like domain (729 - 755)

hEGF

hEGF: Human growth factor-like EGF (774 - 786)

RHS_repeat

RHS_repeat: RHS Repeat (2271 - 2302)

Tox-GHH

Tox-GHH: GHH signature containing HNH/Endo VII superfamily nuclease toxin (2684 - 2762)

  • 0
  • 500
  • 1000
  • 1500
  • 2000
  • 2500
  • 2769 a.a.
蛋白主名 其他名称

teneurin-4

downstream of CHOP 4

TENM4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TENM4 Q6N022 ZNF696 Homo sapiens Q9H7X3
Validated Y2H
32296183
Intra TENM4 Q6N022 SHFL Homo sapiens Q9NUL5-4
Validated Y2H
32296183
Intra TENM4 Q6N022 DOCK2 Homo sapiens Q92608
Validated Y2H
32296183
Intra TENM4 Q6N022 ZNF587 Homo sapiens Q96SQ5
Validated Y2H
32296183
Intra TENM4 Q6N022 LCE3D Homo sapiens Q9BYE3
Validated Y2H
32296183
Intra TENM4 Q6N022 PLSCR4 Homo sapiens Q9NRQ2
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Tremor, Hereditary Essential, 5

ETM5

Essential Tremor 5

Essential Tremor, Hereditary, 5

Hereditary Essential Tremor 5

Tremor, Hereditary Essential 5

Tremor, Essential Hereditary, Type 5
Tremor

Medicament-Induced Tremor

Medication-Induced Postural Tremor
Essential Tremor

Benign Essential Tremor

Familial Tremor

Hereditary Essential Tremor

Essential Hereditary Tremor

Shaky Hand Syndrome

Benign Essential Tremor Syndrome

Tremor Hereditary Essential

Essential Tremor, Susceptibility To

Tremor, Hereditary Essential
Cleft Palate, Proliferative Retinopathy, And Developmental Delay

CPPRDD
Tremor, Hereditary Essential, 1

ETM1

Fet1

Essential Tremor 1

Tremor, Familial Essential, 1

Essential Tremor, Hereditary, 1

Hereditary Essential Tremor 1

Tremor Hereditary Essential, 1

Tremor Familial Essential, 1

Tremor, Hereditary Essential 1

Tremor, Essential Hereditary, Type 1
Bardet-Biedl Syndrome 2

BBS2

Bardet-Biedl Syndrome

Bardet-Biedl Syndrome, Type 2

Bbs
Tremor, Hereditary Essential, 4

ETM4

Essential Tremor 4

Essential Tremor, Hereditary, 4

Hereditary Essential Tremor 4

Tremor, Hereditary Essential 4

Tremor, Hereditary Essential, Type 4
Bipolar Disorder

Bipolar Depression

Manic Disorder

Depression, Bipolar

Bipolar Disorder Manic Phase

Depressive-Manic Psych.

Manic Bipolar Affective Disorder

Manic Bipolar I Disorder

Manic Depression

Manic Depressive Disorder

Mixed Bipolar Disorder

Bipolar Affective Disorder

Bipolar Affective Psychosis

Bipolar Spectrum Disorder

Manic Depressive Illness

Depression Bipolar

Bipolar Disorder, Mixed

Major Affective Disorder

Major Affective Disorder 1

Major Affective Disorder 2
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14365 TENM4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus TENM4 VGNC VGNC:66072
Macaca mulatta TENM4 VGNC VGNC:107649
Canis familiaris TENM4 VGNC VGNC:54999
Mus musculus TENM4 MGD MGI:2447063
Rattus norvegicus TENM4 RGD RGD:1304658
Bos taurus TENM4 VGNC VGNC:35744
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