HPGDS - hematopoietic prostaglandin D synthase Gene

中文名称：造血前列腺素 D 合酶

种属: Homo sapiens

同用名: GSTS; PGD2; PGDS; GSTS1; GSTS1-1

基因 ID: 27306 | 基因类型: protein coding

关于 HPGDS

Cytogenetic location: 4q22.3 Genomic coordinates (GRCh38): 4:94,298,535-94,342,836 (from NCBI)

This gene has 3 transcripts (splice variants), 134 orthologues and 11 paralogues. Broad expression in placenta (RPKM 12.7), lung (RPKM 6.6) and 16 other tissues.

功能概要

前列腺素-D 合酶是 sigma 类谷胱甘肽-S-转移酶家族成员。该酶催化 PGH2 转化为 PGD2，并在免疫系统和肥大细胞中产生前列腺素。这种酶的存在可用于鉴定人巨核细胞的分化阶段。[RefSeq 提供，2008 年 7 月]

Prostaglandin-D synthase is a sigma class glutathione-S-transferase family member. The Enzyme catalyzes the conversion of PGH2 to PGD2 and plays a role in the production of prostanoids in the immune system and mast cells. The presence of this Enzyme can be used to identify the differentiation stage of human megakaryocytes. [provided by RefSeq, Jul 2008]

HPGDS 基因产物(1)

mRNA	Protein	Name
NM_014485.3	NP_055300.1	hematopoietic prostaglandin D synthase

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables calcium ion binding	IDA IDA: 通过直接分析推断	12627223	GOA
enables magnesium ion binding	IDA IDA: 通过直接分析推断	12627223	GOA
enables prostaglandin-D synthase activity	IDA IDA: 通过直接分析推断	12627223	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA
enables protein homodimerization activity	IPI IPI: 通过物理相互作用推断	12627223	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in prostaglandin metabolic process	IDA IDA: 通过直接分析推断	12627223	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HPGDS 蛋白结构

GST_N

GST_C

0
100
199 a.a.

蛋白主名

其他名称

hematopoietic prostaglandin D synthase

GST class-sigma

HPGDS 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	HPGDS	O60760	MELTF	Homo sapiens	P08582-2	Y2H Prey Pooling	25416956
种属内	HPGDS	O60760	LIF	Homo sapiens	P15018	Validated Y2H	32296183
种属内	HPGDS	O60760	SIX6OS1	Homo sapiens	Q8N1H7	Y2H Prey Pooling	32296183
种属内	HPGDS	O60760	SIX6OS1	Homo sapiens	Q8N1H7	Y2H Array	32296183
种属内	HPGDS	O60760	SIX6OS1	Homo sapiens	Q8N1H7	Validated Y2H	32296183
种属内	HPGDS	O60760	ABHD17A	Homo sapiens	Q96GS6	Y2H Array	25416956
种属内	HPGDS	O60760	ABHD17A	Homo sapiens	Q96GS6	Y2H Prey Pooling	25416956
种属内	HPGDS	O60760	ARRDC3	Homo sapiens	Q96B67	Validated Y2H	25416956
种属内	HPGDS	O60760	ARRDC3	Homo sapiens	Q96B67	Validated Y2H	32296183
种属内	HPGDS	O60760	ARRDC3	Homo sapiens	Q96B67	Y2H Array	32296183
种属内	HPGDS	O60760	ARRDC3	Homo sapiens	Q96B67	Y2H Prey Pooling	25416956
种属内	HPGDS	O60760	ARRDC3	Homo sapiens	Q96B67	Y2H Prey Pooling	32296183
种属内	HPGDS	O60760	PDE3B	Homo sapiens	Q13370	Y2H Prey Pooling	32296183
种属内	HPGDS	O60760	PDE3B	Homo sapiens	Q13370	Validated Y2H	32296183
种属内	HPGDS	O60760	PDE3B	Homo sapiens	Q13370	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 HPGDS 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71036	HPGDS Protein, Human	O60760 (M1-L199)	≥95%

关联疾病

疾病名称

别名

O'Nyong'Nyong Fever

O'Nyong-Nyong Fever	O'Nyong-Nyong Mosquito-Borne Viral Fever
O'Nyong-Nyong Arthritis	Onn - [O'Nyong-Nyong Fever]

Intermediate Malignant Teratoma

Malignant Teratoma, Intermediate

Intermediate Immature Teratoma

Short-Rib Thoracic Dysplasia 2 With Or Without Polydactyly

Asphyxiating Thoracic Dystrophy 2	SRTD2
Atd2	Jatd
Jeune Asphyxiating Thoracic Dystrophy	Jeune Syndrome 2

Filarial Elephantiasis

Lymphatic Filariasis	Elephantiasis
Filariasis	Bancroftian Elephantiasis
Bancroftian Filarial Chyluria	Elephantiasis Of Eyelid
Bancroftian Filariasis	Elephantitis
Malayi Tropical Eosinphilia	Wuchereria Bancrofti Infection
Wuchereriasis	Elephantiasis, Filarial
Filarial Elephantiases	Infection By Wuchereria Bancrofti
Filarial Lymphangitis	Tropical Elephantiasis
Filarial Chylocele

Fascioliasis

Fasciola Hepatica Infection	Infection By Fasciola
Sheep Liver Fluke Infection	Liver Flukes
Fasciola Infestation	Sheep Liver Fluke Disease
Liver Fluke Infestation	Liver Flukes Nos
Liver Fluke Infection	Liver Fluke Disease

Parasitic Ectoparasitic Infectious Disease

Ectoparasitic Infestations

Ectoparasitism

Skin Papilloma

Cutaneous Papilloma	Papilloma Of Skin
Papilloma Skin

Inflammatory Bowel Disease 16

IBD16

Inflammatory Bowel Disease 16, Susceptibility To

Methylmalonic Aciduria And Homocystinuria, Cbld Type

Homocystinuria, Cbld Type, Variant 1	Methylmalonic Aciduria And Homocystinuria Type Cbld
Vitamin B12-Responsive Methylmalonic Acidemia, Type Cbldv2	MAHCD
Methylmalonic Acidemia And Homocystinuria, Cbld Type	Methylmalonic Aciduria, Cblh Type, Formerly
Methylmalonic Acidemia, Cblh Type, Formerly	Methylmalonic Aciduria, Cbld Type, Variant 2
Cobalamin D Deficiency	Methylcobalamin Deficiency Type Cbldv1
Functional Methionine Synthase Deficiency Type Cbldv1	Vitamin B12-Responsive Methylmalonic Aciduria, Type Cbldv2
Methylmalonic Acidemia With Homocystinuria, Type Cbld	Cbld Defect
Cobalamin D Defect	Combined Defect In Adenosylcobalamin And Methylcobalamin Synthesis, Type Cbld
Methylmalonic Aciduria With Homocystinuria, Type Cbld	Homocystinuria Cbld Variant 1
Methylmalonic Acidemia And Homocystinuria Cbld Type	Methylmalonic Aciduria And Homocystinuria Cbld-Combined
Methylmalonic Aciduria And Homocystinuria Cbld Original	Methylmalonic Aciduria Cbld Variant 2
Aciduria, Methylmalonic, And Homocystinuria, Cbld Type

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-108259	HQL-79	Inhibitor	99.89%	否
HY-110167	TFC 007	Inhibitor	98.01%	否
HY-12791	hPGDS-IN-1	Inhibitor	99.92%	否
HY-10439	HPGDS inhibitor 1	Inhibitor	99.04%	否
HY-109134	Pizuglanstat	Inhibitor	99.70%	否
HY-139972	PROTAC(H-PGDS)-7		99.42%	否
HY-126134	HPGDS inhibitor 2	Inhibitor	99.72%	否
HY-146662	HPGDS inhibitor 3	Inhibitor	/	否
HY-157577	PROTAC(H-PGDS)-8	Degrader	/	否
HY-RS06338	HPGD Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06339	Hpgd Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06340	Hpgd Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06341	HPGDS Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-109134A	Pizuglanstat hydrate	Inhibitor	/	否
HY-120581	ML388	Inhibitor	/	否
HY-139171	F092	Inhibitor	99.79%	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	HPGDS	VGNC	VGNC:54312
Felis catus	HPGDS	VGNC	VGNC:62837
Macaca mulatta	HPGDS	VGNC	VGNC:73410
Mus musculus	HPGDS	MGD	MGI:1859384
Bos taurus	HPGDS	VGNC	VGNC:29941
Rattus norvegicus	HPGDS	RGD	RGD:69251
Others	HPGDS	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

HPGDS - hematopoietic prostaglandin D synthase Gene

关于 HPGDS

功能概要

HPGDS 基因产物(1)

HPGDS 蛋白结构

HPGDS 蛋白互作信息

重组 HPGDS 蛋白

关联疾病

直系同源

热门区域

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HPGDS - hematopoietic prostaglandin D synthase Gene

关于 HPGDS

功能概要

HPGDS 基因产物(1)

HPGDS 蛋白结构

HPGDS 蛋白互作信息

重组 HPGDS 蛋白

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

N

Q

S

T

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