2. Gene
  3. SLC25A42 - solute carrier family 25 member 42 Gene

SLC25A42 - solute carrier family 25 member 42 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 25 成员 42

种属: Homo sapiens

同用名: MECREN

基因 ID: 284439 | 基因类型: protein coding

关于 SLC25A42

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:19,063,994-19,113,030 (from NCBI)

This gene has 6 transcripts (splice variants), 249 orthologues, 49 paralogues and is associated with 2 phenotypes. Broad expression in kidney (RPKM 18.3), liver (RPKM 12.3) and 24 other tissues.

功能概要

该基因编码溶质载体家族 25 蛋白。溶质载体家族 25 蛋白定位于线粒体，并在分子穿过线粒体内膜的运输中发挥关键作用。编码的蛋白质是辅酶 A (CoA) 和腺苷 3',5'-二磷酸的线粒体转运蛋白。[RefSeq 提供，2012 年 2 月]

This gene encodes a solute carrier family 25 protein. Solute carrier family 25 proteins are localized to mitochondria and play critical roles in the transport of molecules across the inner mitochondrial membrane. The encoded protein is a mitochondrial transporter for coenzyme A (CoA) and adenosine 3',5'-diphosphate. [provided by RefSeq, Feb 2012]

SLC25A42 基因产物(2)

mRNA Protein Name
NM_001321544.2 NP_001308473.1 mitochondrial coenzyme A transporter SLC25A42
NM_178526.5 NP_848621.2 mitochondrial coenzyme A transporter SLC25A42
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ADP phosphatase activity IDA
IDA: 通过直接分析推断
19429682 GOA
enables ADP transmembrane transporter activity IDA
IDA: 通过直接分析推断
19429682 GOA
enables AMP transmembrane transporter activity IDA
IDA: 通过直接分析推断
19429682 GOA
enables ATP transmembrane transporter activity IDA
IDA: 通过直接分析推断
19429682 GOA
enables coenzyme A transmembrane transporter activity EXP
EXP: 通过实验结果推断
19429682 GOA
enables coenzyme A transmembrane transporter activity IDA
IDA: 通过直接分析推断
19429682 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ADP transport IDA
IDA: 通过直接分析推断
19429682 GOA
involved in AMP transport IDA
IDA: 通过直接分析推断
19429682 GOA
involved in ATP transport IDA
IDA: 通过直接分析推断
19429682 GOA
involved in coenzyme A transmembrane transport IDA
IDA: 通过直接分析推断
19429682 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrion IDA
IDA: 通过直接分析推断
19429682 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC25A42 蛋白结构

Mito_carr

Mito_carr: Mitochondrial carrier protein (31 - 120)

Mito_carr

Mito_carr: Mitochondrial carrier protein (129 - 216)

Mito_carr

Mito_carr: Mitochondrial carrier protein (224 - 314)

  • 0
  • 100
  • 200
  • 300
  • 318 a.a.
蛋白主名 其他名称

mitochondrial coenzyme A transporter SLC25A42

SLC25A42 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra SLC25A42 Q86VD7 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra SLC25A42 Q86VD7 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra SLC25A42 Q86VD7 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra SLC25A42 Q86VD7 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra SLC25A42 Q86VD7 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
Intra SLC25A42 Q86VD7 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
Intra SLC25A42 Q86VD7 KRT31 Homo sapiens Q15323
Y2H Array
32296183
Intra SLC25A42 Q86VD7 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Metabolic Crises, Recurrent, With Variable Encephalomyopathic Features And Neurologic Regression

MECREN
Mitochondrial Myopathy

Mitochondrial Myopathies

Mitochondrial Cytopathy

Myopathies In Mitochondrial Disorders
Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant 2

PEOA2

Autosomal Dominant Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions 2

Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant, 2

Chronic Progressive External Ophthalmoplegia

Progressive External Ophthalmoplegia, Autosomal Dominant 2

Autosomal Dominant Progressive External Ophthalmoplegia 2

Cpeo

Graefe Disease

Mitochondrial Ocular Myopathy

Ocular Myopathy Of Von Graefe-Fuchs

Progressive External Ophthalmoplegia Autosomal Dominant 2

Ophthalmoplegia, External, Progressive, With Mitochondrial Dna Deletions, Autosomal Dominant, Type 2

Kearns-Sayre Syndrome
Lactic Acidosis

Acidosis, Lactic

Acidosis Lactic
Combined D-2- And L-2-Hydroxyglutaric Aciduria

D,L-2-Hydroxyglutaric Aciduria

D2L2AD

Combined D-2-Hydroxyglutaric Acidemia And L-2-Hydroxyglutaric Acidemia

Combined D-2-Hydroxyglutaric Aciduria And L-2-Hydroxyglutaric Aciduria

D,L-2-Hga

D,L-2-Hydroxyglutaric Acidemia

Combined D,L-2-Hydroxyglutaric Aciduria
Developmental And Epileptic Encephalopathy 39

Hypomyelination, Global Cerebral

Agc1 Deficiency

Epileptic Encephalopathy, Early Infantile, 39

DEE39

Eiee39

Aspartate-Glutamate Carrier 1 Deficiency

Epileptic Encephalopathy With Global Cerebral Demyelination

Developmental And Epileptic Encephalopathy, 39

Early Infantile Epileptic Encephalopathy 39

Mitochondrial Aspartate-Glutamate Carrier 1 Deficiency

Global Cerebral Hypomyelination

Hereditary Central Nervous System Demyelinating Diseases
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13124 SLC25A42 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SLC25A42 VGNC VGNC:46313
Felis catus SLC25A42 VGNC VGNC:65276
Bos taurus SLC25A42 VGNC VGNC:34767
Macaca mulatta SLC25A42 VGNC VGNC:77579
Mus musculus SLC25A42 MGD MGI:1920345
Rattus norvegicus SLC25A42 RGD RGD:1592346
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